GB888038A - Medicinal tablet - Google Patents
Medicinal tabletInfo
- Publication number
- GB888038A GB888038A GB22359A GB22359A GB888038A GB 888038 A GB888038 A GB 888038A GB 22359 A GB22359 A GB 22359A GB 22359 A GB22359 A GB 22359A GB 888038 A GB888038 A GB 888038A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tablet
- recess
- active ingredients
- portions
- inlay
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004480 active ingredient Substances 0.000 abstract 3
- VIROVYVQCGLCII-UHFFFAOYSA-N amobarbital Chemical compound CC(C)CCC1(CC)C(=O)NC(=O)NC1=O VIROVYVQCGLCII-UHFFFAOYSA-N 0.000 abstract 2
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 abstract 2
- PYHRZPFZZDCOPH-QXGOIDDHSA-N (S)-amphetamine sulfate Chemical compound [H+].[H+].[O-]S([O-])(=O)=O.C[C@H](N)CC1=CC=CC=C1.C[C@H](N)CC1=CC=CC=C1 PYHRZPFZZDCOPH-QXGOIDDHSA-N 0.000 abstract 1
- JXYWFNAQESKDNC-BTJKTKAUSA-N (z)-4-hydroxy-4-oxobut-2-enoate;2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl-dimethylazanium Chemical compound OC(=O)\C=C/C(O)=O.C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 JXYWFNAQESKDNC-BTJKTKAUSA-N 0.000 abstract 1
- JWDYCNIAQWPBHD-UHFFFAOYSA-N 1-(2-methylphenyl)glycerol Chemical compound CC1=CC=CC=C1OCC(O)CO JWDYCNIAQWPBHD-UHFFFAOYSA-N 0.000 abstract 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 abstract 1
- DYWNLSQWJMTVGJ-KUSKTZOESA-N Phenylpropanolamine hydrochloride Chemical compound Cl.C[C@H](N)[C@H](O)C1=CC=CC=C1 DYWNLSQWJMTVGJ-KUSKTZOESA-N 0.000 abstract 1
- 229920001800 Shellac Polymers 0.000 abstract 1
- 244000007731 Tolu balsam tree Species 0.000 abstract 1
- 235000007423 Tolu balsam tree Nutrition 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229960001301 amobarbital Drugs 0.000 abstract 1
- 239000002830 appetite depressant Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000013869 carnauba wax Nutrition 0.000 abstract 1
- 239000004203 carnauba wax Substances 0.000 abstract 1
- 229940082483 carnauba wax Drugs 0.000 abstract 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 abstract 1
- 239000000850 decongestant Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002702 enteric coating Substances 0.000 abstract 1
- 238000009505 enteric coating Methods 0.000 abstract 1
- 239000003925 fat Substances 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229960003861 mephenesin Drugs 0.000 abstract 1
- 239000001673 myroxylon balsanum l. absolute Substances 0.000 abstract 1
- 229960001412 pentobarbital Drugs 0.000 abstract 1
- 229960002305 phenylpropanolamine hydrochloride Drugs 0.000 abstract 1
- 229940018203 pyrilamine maleate Drugs 0.000 abstract 1
- 235000013874 shellac Nutrition 0.000 abstract 1
- 239000004208 shellac Substances 0.000 abstract 1
- 229940113147 shellac Drugs 0.000 abstract 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 abstract 1
- 229940088660 tolu balsam Drugs 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
Abstract
888,038. Medicinal tablets. TRIGGS, W. W. (Wander Co.). Dec. 16, 1959, No. 42823/59. Class 81 (1). A medicinal tablet, other than an implantation tablet, comprises a main body portion 11 with a recess 12 in at least one side thereof and an inlay portion 13 disposed in and substantially filling said recess and forming with said main body portion a unitary tablet. In order to achieve differential release of the medicaments contained in the two portions in the gastrointestinal tract, the granules of either or both of said portions may be enteric coated prior to the formation of the tablet and in one embodiment the inlay portion is enteric coated as a whole. Specified enteric coating materials are cellulose acetate phthalate, tolu balsam, carnauba wax, alcoholic shellac solutions and hydrogenated fats. In other embodiments the recess 12 may be undercut to an extent sufficient to afford mechanical anchorage of the inlay portion or the tablet may have two inlay portions, one on either side of the tablet. The tablets may be circular, triangular, rectangular or cylindrical. The examples described (a) an appetite depressant tablet which contains as active ingredients d-amphetamine sulphate and amobarbital; (b) a decongestant tablet in which the active ingredients are phenyl propanolamine hydrochloride, pyrilamine maleate and phenuramine maleate; and (c) a hypnotic tablet in which the active ingredients are pentobarbital and mephenesin.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US752768A US3048526A (en) | 1958-08-04 | 1958-08-04 | Medicinal tablet |
| GB22359A GB888038A (en) | 1959-12-16 | 1959-12-16 | Medicinal tablet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB22359A GB888038A (en) | 1959-12-16 | 1959-12-16 | Medicinal tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB888038A true GB888038A (en) | 1962-01-24 |
Family
ID=9700583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22359A Expired GB888038A (en) | 1958-08-04 | 1959-12-16 | Medicinal tablet |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB888038A (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0656204A1 (en) * | 1993-11-30 | 1995-06-07 | EKITA Investments N.V. | Controlled release pharmaceutical tablet having lenticular form |
| US6183778B1 (en) | 1993-09-21 | 2001-02-06 | Jagotec Ag | Pharmaceutical tablet capable of liberating one or more drugs at different release rates |
| WO2003026628A3 (en) * | 2001-09-28 | 2003-05-01 | Mcneil Ppc Inc | Composite dosage forms having an inlaid portion |
| WO2005065639A3 (en) * | 2003-11-21 | 2005-09-01 | Torrent Pharmaceuticals Ltd | Novel pharmaceutical compositions |
| US6982094B2 (en) | 2001-09-28 | 2006-01-03 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
| US7122143B2 (en) | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
| US7217381B2 (en) | 2001-09-28 | 2007-05-15 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
| US7323192B2 (en) | 2001-09-28 | 2008-01-29 | Mcneil-Ppc, Inc. | Immediate release tablet |
| EP1228125A4 (en) * | 1999-09-14 | 2009-09-02 | Smithkline Beecham Corp | Process for making aqueous coated beadlets |
| US7807197B2 (en) | 2002-09-28 | 2010-10-05 | Mcneil-Ppc, Inc. | Composite dosage forms having an inlaid portion |
| US7838026B2 (en) | 2001-09-28 | 2010-11-23 | Mcneil-Ppc, Inc. | Burst-release polymer composition and dosage forms comprising the same |
| US8673352B2 (en) | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form |
-
1959
- 1959-12-16 GB GB22359A patent/GB888038A/en not_active Expired
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6183778B1 (en) | 1993-09-21 | 2001-02-06 | Jagotec Ag | Pharmaceutical tablet capable of liberating one or more drugs at different release rates |
| EP0656204A1 (en) * | 1993-11-30 | 1995-06-07 | EKITA Investments N.V. | Controlled release pharmaceutical tablet having lenticular form |
| US5626874A (en) * | 1993-11-30 | 1997-05-06 | Ekita Investments N.V. | Controlled release pharmaceutical tablet having lenticular form |
| EP1228125A4 (en) * | 1999-09-14 | 2009-09-02 | Smithkline Beecham Corp | Process for making aqueous coated beadlets |
| US6982094B2 (en) | 2001-09-28 | 2006-01-03 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
| US7635490B2 (en) | 2001-09-28 | 2009-12-22 | Mcneil-Ppc, Inc. | Modified release dosage form |
| US7122143B2 (en) | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
| US7217381B2 (en) | 2001-09-28 | 2007-05-15 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
| US7297345B2 (en) | 2001-09-28 | 2007-11-20 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
| US7323192B2 (en) | 2001-09-28 | 2008-01-29 | Mcneil-Ppc, Inc. | Immediate release tablet |
| WO2003026628A3 (en) * | 2001-09-28 | 2003-05-01 | Mcneil Ppc Inc | Composite dosage forms having an inlaid portion |
| US8673190B2 (en) | 2001-09-28 | 2014-03-18 | Mcneil-Ppc, Inc. | Method for manufacturing dosage forms |
| US8545887B2 (en) | 2001-09-28 | 2013-10-01 | Mcneil-Ppc, Inc. | Modified release dosage forms |
| US7838026B2 (en) | 2001-09-28 | 2010-11-23 | Mcneil-Ppc, Inc. | Burst-release polymer composition and dosage forms comprising the same |
| US7968120B2 (en) | 2001-09-28 | 2011-06-28 | Mcneil-Ppc, Inc. | Modified release dosage forms |
| US7972624B2 (en) | 2001-09-28 | 2011-07-05 | Shun-Por Li | Method of manufacturing modified release dosage forms |
| US8114328B2 (en) | 2001-09-28 | 2012-02-14 | Mcneil-Ppc, Inc. | Method of coating a dosage form comprising a first medicant |
| US7807197B2 (en) | 2002-09-28 | 2010-10-05 | Mcneil-Ppc, Inc. | Composite dosage forms having an inlaid portion |
| WO2005065639A3 (en) * | 2003-11-21 | 2005-09-01 | Torrent Pharmaceuticals Ltd | Novel pharmaceutical compositions |
| US8673352B2 (en) | 2005-04-15 | 2014-03-18 | Mcneil-Ppc, Inc. | Modified release dosage form |
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