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GB887359A - Sulphonyl-ureas and a process for preparing them - Google Patents

Sulphonyl-ureas and a process for preparing them

Info

Publication number
GB887359A
GB887359A GB24771/58A GB2477158A GB887359A GB 887359 A GB887359 A GB 887359A GB 24771/58 A GB24771/58 A GB 24771/58A GB 2477158 A GB2477158 A GB 2477158A GB 887359 A GB887359 A GB 887359A
Authority
GB
United Kingdom
Prior art keywords
sulphonyl
formula
alkyl
acyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24771/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of GB887359A publication Critical patent/GB887359A/en
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises sulphonyl mercapto-ethyl ureas of the formula R.SO2.NH.CO.NH.CH2.CH2.SH and corresponding disulphides of the formula <FORM:0887359/IV (b)/1> wherein R is phenyl optionally bearing 1 or 2 halogen or C1-4 alkyl or alkoxy substituents or a cycloalkyl or cycloalkyl-alkyl group of 6 or 7 carbon atoms, and their salts with physiologically tolerable bases. The compounds are made by reacting a sulphonyl urethane R.SO2.NH.COOR1 (R1=alkyl) or a sulphonyl acyl urea R.SO2.NH. CO.NH. acyl with cysteamine and optionally oxidising the resulting mercapto compound to the disulphide, e.g. with hydrogen peroxide, iodine or potassium ferricyanide, or by reacting a sulphonyl isocyanate R.SO2.NCO, a sulphonyl urethane R.SO2.NH.COOR1 or a sulphonyl acyl urea R.SO2.NH.CO.NH acyl with cystamine.ALSO:Preparations suitable for oral administration and having hypoglycaemic acitivity comprise sulphonyl mercaptoethyl ureas of the formula R.SO2.NH.CO.NH.CR2CH2.SH or the corresponding disulphides of the formula R.SO2.NH.CO.NH.CH2CH2.S.S.CH2CH2. NH.CO.NH.SO2.R wherein R is a phenyl radical optionally bearing one or two halogen or C1-4 alkyl or alkoxy substituents or is a cycloalkyl or cycloalkylalkyl radical of 6 or 7 carbon atoms (see Group IV (b)) in admixture or conjunction with a pharmaceutical carrier. The preparations suitably take the form of tablets, dragees, capsules or drops.
GB24771/58A 1957-07-31 1958-07-31 Sulphonyl-ureas and a process for preparing them Expired GB887359A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE887359X 1957-07-31

Publications (1)

Publication Number Publication Date
GB887359A true GB887359A (en) 1962-01-17

Family

ID=6833764

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24771/58A Expired GB887359A (en) 1957-07-31 1958-07-31 Sulphonyl-ureas and a process for preparing them

Country Status (1)

Country Link
GB (1) GB887359A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3353901A (en) * 1962-02-21 1967-11-21 Bayer Ag Increasing wash fastness of dyes on cellulosic materials with nu-methylolated quaternary ammonium ureido and urethane compounds
US5389682A (en) * 1992-09-18 1995-02-14 Warner-Lambert Company Agents acting at cholecystokinin receptors

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3353901A (en) * 1962-02-21 1967-11-21 Bayer Ag Increasing wash fastness of dyes on cellulosic materials with nu-methylolated quaternary ammonium ureido and urethane compounds
US5389682A (en) * 1992-09-18 1995-02-14 Warner-Lambert Company Agents acting at cholecystokinin receptors

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