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GB8828517D0 - Stable emulsions - Google Patents

Stable emulsions

Info

Publication number
GB8828517D0
GB8828517D0 GB888828517A GB8828517A GB8828517D0 GB 8828517 D0 GB8828517 D0 GB 8828517D0 GB 888828517 A GB888828517 A GB 888828517A GB 8828517 A GB8828517 A GB 8828517A GB 8828517 D0 GB8828517 D0 GB 8828517D0
Authority
GB
United Kingdom
Prior art keywords
zeta potential
fat emulsion
doubly
triply charged
emulsion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB888828517A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leopold & Co AG
Original Assignee
Leopold & Co AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10648081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB8828517(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Leopold & Co AG filed Critical Leopold & Co AG
Priority to GB888828517A priority Critical patent/GB8828517D0/en
Publication of GB8828517D0 publication Critical patent/GB8828517D0/en
Priority to EP89121784A priority patent/EP0372331B1/en
Priority to AT89121784T priority patent/ATE80551T1/en
Priority to DE8989121784T priority patent/DE58902296D1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Fat emulsion for parenteral administration of the oil-in-water type with a phospholipid as emulsifier, on whose disperse phase a positive zeta potential of at least +7 mV has been conferred by a content of doubly and/or triply charged metal cations, in particular calcium, magnesium and triply charged iron ion, in physiologically acceptable concentration. This positively charged fat emulsion can be prepared by starting from phospholipids which have a low charge and which in dispersion produce a negative zeta potential not exceeding -20 mV, preferably from virtually uncharged phospholipids, and bringing about the change to the positive zeta potential by adding the doubly and/or triply charged cations before or after the preparation of the emulsion. The fat emulsion is distinguished by stability, especially towards added electrolytes, and can thus advantageously be employed as a basis for complete alimentation systems.
GB888828517A 1988-12-07 1988-12-07 Stable emulsions Pending GB8828517D0 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB888828517A GB8828517D0 (en) 1988-12-07 1988-12-07 Stable emulsions
EP89121784A EP0372331B1 (en) 1988-12-07 1989-11-25 Stable fat emulsion for parenteral administration
AT89121784T ATE80551T1 (en) 1988-12-07 1989-11-25 STABLE FAT EMULSION FOR PARENTERAL ADMINISTRATION.
DE8989121784T DE58902296D1 (en) 1988-12-07 1989-11-25 STABLE FAT EMULSION FOR PARENTERAL ADMINISTRATION.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888828517A GB8828517D0 (en) 1988-12-07 1988-12-07 Stable emulsions

Publications (1)

Publication Number Publication Date
GB8828517D0 true GB8828517D0 (en) 1989-01-11

Family

ID=10648081

Family Applications (1)

Application Number Title Priority Date Filing Date
GB888828517A Pending GB8828517D0 (en) 1988-12-07 1988-12-07 Stable emulsions

Country Status (4)

Country Link
EP (1) EP0372331B1 (en)
AT (1) ATE80551T1 (en)
DE (1) DE58902296D1 (en)
GB (1) GB8828517D0 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101241A (en) * 1992-03-16 1997-11-20 Yissum Res Dev Co Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier
GB9405593D0 (en) * 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
US5731355A (en) * 1994-03-22 1998-03-24 Zeneca Limited Pharmaceutical compositions of propofol and edetate
US20020173547A1 (en) 1994-03-22 2002-11-21 Jones Christopher Buchan Pharmaceuticals compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78929A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration

Also Published As

Publication number Publication date
EP0372331A1 (en) 1990-06-13
EP0372331B1 (en) 1992-09-16
DE58902296D1 (en) 1992-10-22
ATE80551T1 (en) 1992-10-15

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