GB8702288D0 - Cinnoline-carboxamides - Google Patents
Cinnoline-carboxamidesInfo
- Publication number
- GB8702288D0 GB8702288D0 GB878702288A GB8702288A GB8702288D0 GB 8702288 D0 GB8702288 D0 GB 8702288D0 GB 878702288 A GB878702288 A GB 878702288A GB 8702288 A GB8702288 A GB 8702288A GB 8702288 D0 GB8702288 D0 GB 8702288D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- unsubstituted
- substituted
- alkoxy
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LBGQERGEZNQMAT-UHFFFAOYSA-N cinnoline-3-carboxamide Chemical class C1=CC=C2N=NC(C(=O)N)=CC2=C1 LBGQERGEZNQMAT-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- -1 nitro, amino, formylamino Chemical group 0.000 abstract 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000037581 Persistent Infection Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000005936 piperidyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000005505 thiomorpholino group Chemical group 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The invention relates to compounds having the general formula (I) <CHEM> wherein n is zero, 1 or 2; each of R1 and R2 is independently: a) hydrogen, halogen, trifluoromethyl or C1-C6 alkyl; b) hydroxy, C1-C6 alkoxy or C3-C4 alkenyloxy; c) nitro, amino, formylamino or C2-C8 alkanoylamino; R3 represents hydrogen or C1-C8 alkyl; R4 is: a') C1-C20 alkyl, unsubstituted or substituted by <CHEM> wherein each of Ra and Rb is independently phenyl or C1-C6 alkyl, or Ra and Rb, taken together with the nitrogen atom to which they are linked, form a N-pyrrolidinyl, N-piperazinyl, hexahydroazepin-1-yl, thiomorpholino, morpholino or piperidino ring, wherein said heterocyclic rings may be unsubstituted or substituted by C1-C6 alkyl or phenyl; b') C5-C10 cycloalkyl, unsubstituted or substituted by methyl; c') 2- or 3-pyrrolidinyl, piperidyl of 2-piperazinyl, wherein said heterocyclic rings may be unsubstituted or substituted by C1-C6 alkyl; d') isoxazolyl or thiazolyl, wherein said heterocyclic rings may be unsubstituted or substituted by C1-C6 alkyl; e') pyridyl, unsubstituted or substituted by one or two substituents chosen independently from halogen, C1-C6 alkyl and C1-C6 alkoxy; or f') phenyl, unsubstituted or substituted by one or two substituents chosen independently from halogen, CF3,C1-C6 alkyl, C1-C6 alkoxy, amino, nitro, formylamino and C2-C8 alkanoylamino, and the pharmaceutically acceptable salts thereof, which possess immunomodulating activity and are useful e.g. in the treatment of neoplastic diseases and acute and chronic infections of both bacterial and viral origin in mammals.
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878702288A GB8702288D0 (en) | 1987-02-02 | 1987-02-02 | Cinnoline-carboxamides |
| US07/148,702 US4826837A (en) | 1987-02-02 | 1988-01-26 | Cinnoline-carboxamides and process for their preparation |
| IL85221A IL85221A (en) | 1987-02-02 | 1988-01-27 | Pharmaceutical compositions containing cinnoline-carboxamides,certain such novel compounds and their preparation |
| FI880376A FI91405C (en) | 1987-02-02 | 1988-01-28 | Process for the preparation of biologically active cinnoline carboxamides |
| AU10908/88A AU605541B2 (en) | 1987-02-02 | 1988-01-28 | Cinnoline-carboxamides and process for their preparation |
| DK048488A DK48488A (en) | 1987-02-02 | 1988-01-29 | CINNOLIN CARBOXAMIDES AND PROCEDURES FOR PREPARING THEREOF |
| NZ223350A NZ223350A (en) | 1987-02-02 | 1988-01-29 | 4-hydroxycinnoline-carboxamides and pharmaceutical compositions |
| HU88435A HU207053B (en) | 1987-02-02 | 1988-02-01 | Process for producing cinnolinecarboxamide derivatives and pharmaceuitcal compositions comprising such compounds |
| ZA88686A ZA88686B (en) | 1987-02-02 | 1988-02-01 | Cinnoline-carboxamides and process for their preparation |
| IE26488A IE61161B1 (en) | 1987-02-02 | 1988-02-01 | Cinnoline-carboxamides and process for their preparation |
| ES88300823T ES2058247T3 (en) | 1987-02-02 | 1988-02-01 | 4-HYDROXYCINNOLIN-CARBOXAMIDES, ITS USE AND METHOD OF PREPARATION. |
| EP88300823A EP0277791B1 (en) | 1987-02-02 | 1988-02-01 | Cinnoline-carboxamides and process for their preparation |
| DE88300823T DE3881407T2 (en) | 1987-02-02 | 1988-02-01 | Cinnoline carboxylic acid amides and process for their preparation. |
| PT86677A PT86677B (en) | 1987-02-02 | 1988-02-01 | METHOD FOR THE PREPARATION OF CINOLINE-CARBOXAMIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| AT88300823T ATE90083T1 (en) | 1987-02-02 | 1988-02-01 | CINNOLIN CARBON ACID AMIDES AND PROCESS FOR THEIR PREPARATION. |
| SU884355119A SU1563592A3 (en) | 1987-02-02 | 1988-02-01 | Method of producing cynnoline carboxamides or their pharmaceutically acceptable salts |
| CA000557868A CA1309407C (en) | 1987-02-02 | 1988-02-01 | Cinnoline-carboxamides and process for their preparation |
| JP63022671A JPS63225363A (en) | 1987-02-02 | 1988-02-02 | Cinnoline carboxide and its manufacturing method |
| MYPI88000096A MY103055A (en) | 1987-02-02 | 1988-02-02 | Cinnoline-carboxamides and process for their preparation. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878702288A GB8702288D0 (en) | 1987-02-02 | 1987-02-02 | Cinnoline-carboxamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB8702288D0 true GB8702288D0 (en) | 1987-03-11 |
Family
ID=10611587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB878702288A Pending GB8702288D0 (en) | 1987-02-02 | 1987-02-02 | Cinnoline-carboxamides |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4826837A (en) |
| EP (1) | EP0277791B1 (en) |
| JP (1) | JPS63225363A (en) |
| AT (1) | ATE90083T1 (en) |
| AU (1) | AU605541B2 (en) |
| CA (1) | CA1309407C (en) |
| DE (1) | DE3881407T2 (en) |
| DK (1) | DK48488A (en) |
| ES (1) | ES2058247T3 (en) |
| FI (1) | FI91405C (en) |
| GB (1) | GB8702288D0 (en) |
| HU (1) | HU207053B (en) |
| IE (1) | IE61161B1 (en) |
| IL (1) | IL85221A (en) |
| MY (1) | MY103055A (en) |
| NZ (1) | NZ223350A (en) |
| PT (1) | PT86677B (en) |
| SU (1) | SU1563592A3 (en) |
| ZA (1) | ZA88686B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8513639D0 (en) * | 1985-05-30 | 1985-07-03 | Ici America Inc | Cinnoline compounds |
| FR2683221B1 (en) * | 1991-11-04 | 1994-03-04 | Fabre Medicament Pierre | NEW CINNOLINONES-4 DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION. |
| JPH05310732A (en) * | 1992-03-12 | 1993-11-22 | Mitsubishi Kasei Corp | Cinnoline-3-carboxylic acid derivative |
| US7217722B2 (en) * | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| CN1406228A (en) * | 2000-03-21 | 2003-03-26 | 法玛西雅厄普约翰美国公司 | 4-oxo-1,4-dihydro-3-cinnolinecarboxamides as antiviral agents |
| AU2001243240A1 (en) | 2000-03-21 | 2001-10-15 | Pharmacia And Upjohn Company Llc | 4-oxo-1,4-dihydro(1,8)naphthyridine-3-carboxamides as antiviral agents |
| MXPA02009248A (en) * | 2000-03-21 | 2003-03-12 | Upjohn Co | 4 hydroxycinnoline 3 carboxyamides as antiviral agents. |
| US6413958B2 (en) | 2000-03-21 | 2002-07-02 | Pharmacia & Upjohn Company | 4-hydroxy-1,8-naphthyridine-3-carboxamides as antiviral agents |
| AU2006254897A1 (en) * | 2005-06-06 | 2006-12-14 | Fibrogen, Inc. | Improved treatment for anemia using a HIF-alpha stabilising agent |
| TW200911760A (en) * | 2007-06-19 | 2009-03-16 | Astrazeneca Ab | Compounds and uses thereof |
| KR101713402B1 (en) * | 2015-03-06 | 2017-03-07 | 엘지전자 주식회사 | Cooking device |
| EP4296075A1 (en) * | 2022-06-23 | 2023-12-27 | LANXESS Deutschland GmbH | Rubber compositions containing ethoxylated alcohol |
| EP4543978A1 (en) * | 2022-06-23 | 2025-04-30 | LANXESS Deutschland GmbH | Rubber blends containing ethoxylated alcohol |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1474399A (en) * | 1974-08-19 | 1977-05-25 | Ici Ltd | Cinnolin-3-yl carboxylic acids and derivatives thereof |
| US4085103A (en) * | 1974-11-07 | 1978-04-18 | Imperial Chemical Industries Limited | 6-Substituted-4-hydroxycinnolin-3-yl-carboxylic acids and esters thereof |
| GB1472766A (en) * | 1974-11-07 | 1977-05-04 | Ici Ltd | Hydroxycinnoline derivatives processes for their preparation and their use in pharmaceutical compositions |
| GB8513639D0 (en) * | 1985-05-30 | 1985-07-03 | Ici America Inc | Cinnoline compounds |
-
1987
- 1987-02-02 GB GB878702288A patent/GB8702288D0/en active Pending
-
1988
- 1988-01-26 US US07/148,702 patent/US4826837A/en not_active Expired - Fee Related
- 1988-01-27 IL IL85221A patent/IL85221A/en not_active IP Right Cessation
- 1988-01-28 FI FI880376A patent/FI91405C/en not_active IP Right Cessation
- 1988-01-28 AU AU10908/88A patent/AU605541B2/en not_active Ceased
- 1988-01-29 DK DK048488A patent/DK48488A/en not_active Application Discontinuation
- 1988-01-29 NZ NZ223350A patent/NZ223350A/en unknown
- 1988-02-01 DE DE88300823T patent/DE3881407T2/en not_active Expired - Fee Related
- 1988-02-01 AT AT88300823T patent/ATE90083T1/en not_active IP Right Cessation
- 1988-02-01 SU SU884355119A patent/SU1563592A3/en active
- 1988-02-01 CA CA000557868A patent/CA1309407C/en not_active Expired - Lifetime
- 1988-02-01 HU HU88435A patent/HU207053B/en unknown
- 1988-02-01 ZA ZA88686A patent/ZA88686B/en unknown
- 1988-02-01 PT PT86677A patent/PT86677B/en not_active IP Right Cessation
- 1988-02-01 IE IE26488A patent/IE61161B1/en not_active IP Right Cessation
- 1988-02-01 EP EP88300823A patent/EP0277791B1/en not_active Expired - Lifetime
- 1988-02-01 ES ES88300823T patent/ES2058247T3/en not_active Expired - Lifetime
- 1988-02-02 MY MYPI88000096A patent/MY103055A/en unknown
- 1988-02-02 JP JP63022671A patent/JPS63225363A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US4826837A (en) | 1989-05-02 |
| MY103055A (en) | 1993-04-30 |
| FI91405C (en) | 1994-06-27 |
| IE61161B1 (en) | 1994-10-05 |
| IL85221A (en) | 1992-09-06 |
| ATE90083T1 (en) | 1993-06-15 |
| IE880264L (en) | 1988-08-02 |
| JPS63225363A (en) | 1988-09-20 |
| ES2058247T3 (en) | 1994-11-01 |
| AU1090888A (en) | 1988-08-04 |
| IL85221A0 (en) | 1988-07-31 |
| DK48488A (en) | 1988-08-03 |
| CA1309407C (en) | 1992-10-27 |
| FI91405B (en) | 1994-03-15 |
| NZ223350A (en) | 1990-08-28 |
| FI880376A0 (en) | 1988-01-28 |
| EP0277791A3 (en) | 1990-04-18 |
| DE3881407T2 (en) | 1993-09-30 |
| DK48488D0 (en) | 1988-01-29 |
| SU1563592A3 (en) | 1990-05-07 |
| PT86677B (en) | 1992-04-30 |
| AU605541B2 (en) | 1991-01-17 |
| HU207053B (en) | 1993-03-01 |
| DE3881407D1 (en) | 1993-07-08 |
| PT86677A (en) | 1988-03-01 |
| HUT56551A (en) | 1991-09-30 |
| FI880376A7 (en) | 1988-08-03 |
| EP0277791B1 (en) | 1993-06-02 |
| EP0277791A2 (en) | 1988-08-10 |
| ZA88686B (en) | 1989-10-25 |
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