GB868482A - Process for the preparation of 8ª--hydroxy-2ª--methoxy-3ª-,5ª--epoxy 1,2,3,4,4aª-,5,8,8aª--octahydronaphthalene-1ª--carboxylic acid lactone and intermediates obtained therein - Google Patents
Process for the preparation of 8ª--hydroxy-2ª--methoxy-3ª-,5ª--epoxy 1,2,3,4,4aª-,5,8,8aª--octahydronaphthalene-1ª--carboxylic acid lactone and intermediates obtained thereinInfo
- Publication number
- GB868482A GB868482A GB548/59A GB54859A GB868482A GB 868482 A GB868482 A GB 868482A GB 548/59 A GB548/59 A GB 548/59A GB 54859 A GB54859 A GB 54859A GB 868482 A GB868482 A GB 868482A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methoxy
- epoxy
- carboxylic acid
- octahydronaphthalene
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The lactone of 8b -hydroxy-2a-methoxy-3b ,5b -epoxy- 1,2,3,4,4aa ,5,8, 8aa -octahydronaphthalene-1b -carboxylic acid <FORM:0868482/IV (b)/1> is made by converting the bromohydrins derived from the mother liquor of crystallisation from the 1,8-lactone of 6a -bromo-7b ,8b -dihydroxy-2a -methoxy-3b ,5b -epoxy- 4aa ,8aa , decahydronaphthalene-1b -carboxylic acid into their tosylates by the action of tosyl chloride in the presence of a tertiary base, and subjecting the resulting mixture of tosylates to reduction with zinc and an aliphatic acid containing 1 to 8 carbon atoms in the presence of an inert organic solvent, The invention also relates to the tosylates of a mixture of two bromohydrins, of which one melts at Ca.158 DEG to Ca.160 DEG C. and the other melts at Ca.184 DEG C., and which bromohydrins are isomeric with the compound of the formula: <FORM:0868482/IV (b)/2> Specifications 868,475 and 868,483 are referred to. Reference has been directed by the Comptroller to Specification 799,269.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR868482X | 1958-01-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB868482A true GB868482A (en) | 1961-05-17 |
Family
ID=9346157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB548/59A Expired GB868482A (en) | 1958-01-09 | 1959-01-06 | Process for the preparation of 8ª--hydroxy-2ª--methoxy-3ª-,5ª--epoxy 1,2,3,4,4aª-,5,8,8aª--octahydronaphthalene-1ª--carboxylic acid lactone and intermediates obtained therein |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB868482A (en) |
-
1959
- 1959-01-06 GB GB548/59A patent/GB868482A/en not_active Expired
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