GB857362A - Quinazoline derivatives - Google Patents
Quinazoline derivativesInfo
- Publication number
- GB857362A GB857362A GB3896358A GB3896358A GB857362A GB 857362 A GB857362 A GB 857362A GB 3896358 A GB3896358 A GB 3896358A GB 3896358 A GB3896358 A GB 3896358A GB 857362 A GB857362 A GB 857362A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- radical
- formula
- hydrogen
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the formula: <FORM:0857362/IV(b)/1> wherein R1 stands for hydrogen or an alkyl or hydroxyalkyl radical and R11 stands for hydrogen or an alkyl or hydroxyalkyl or 2-furyl radical or an amino radical, or wherein R1 and R11 together with the adjacent nitrogen atom represent a heterocyclic ring of not more than 6 atoms, and the preparation thereof by treating a compound of the formula: <FORM:0857362/IV(b)/2> where Y represents a halogen atom with R1,NH,R11, and pharmaceutical compositions containing the products. The products have chemotherapeutic activity. 4-Chloro-6-nitro-2-trichloromethyl - quinazoline is prepared by treating the corresponding 4-hydroxy compound with phosphorus pentachloride. 4-Hydroxy-6-nitro-2-trichloromethyl - quinazoline is prepared by chlorinating the corresponding 2-methyl compound.ALSO:Pharmaceutical compositions containing compounds of the formula: <FORM:0857362/VI/1> wherein R1 represents hydrogen or an alkyl or hydroxyalkyl radical and R11 represents hydrogen or an alkyl, hydroxy alkyl, 2-furyl or an amino radical, or wherein R1 and R11 together with the adjacent nitrogen atom represent a heterocyclic ring of not more than 6 atoms, with a diluent may be in the form of ointments, creams or pastes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3896358A GB857362A (en) | 1958-12-03 | 1958-12-03 | Quinazoline derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3896358A GB857362A (en) | 1958-12-03 | 1958-12-03 | Quinazoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB857362A true GB857362A (en) | 1960-12-29 |
Family
ID=10406774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3896358A Expired GB857362A (en) | 1958-12-03 | 1958-12-03 | Quinazoline derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB857362A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658902A (en) * | 1994-12-22 | 1997-08-19 | Warner-Lambert Company | Quinazolines as inhibitors of endothelin converting enzyme |
-
1958
- 1958-12-03 GB GB3896358A patent/GB857362A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658902A (en) * | 1994-12-22 | 1997-08-19 | Warner-Lambert Company | Quinazolines as inhibitors of endothelin converting enzyme |
| US5773444A (en) * | 1994-12-22 | 1998-06-30 | Warner-Lambert Company | Quinazolines as inhibitors of endothelin converting enzyme |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1144001A (en) | Antimicrobial compositions | |
| GB1120463A (en) | Derivatives of 1,3-diazafluoranthene-1-oxide | |
| GB1131191A (en) | New imidazole derivatives, their preparation and use | |
| ES406374A1 (en) | 1- trifluoromethyl-phenyl- 4-cyclic-amidoalkyl- piperazines useful as amorectic agents | |
| GB1023793A (en) | The manufacture of benzodiazepine derivatives | |
| GB1185045A (en) | Amine Derivatives | |
| ES422906A1 (en) | Derivatives of 2-aminoindane, the preparation and use thereof | |
| GB857362A (en) | Quinazoline derivatives | |
| ES392093A1 (en) | 2-amino-5-chloro-thiazole derivatives | |
| GB1169945A (en) | Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives | |
| ES400587A1 (en) | Production of heterocyclic compound | |
| GB1364294A (en) | 2-styrylquinazoline compounds | |
| GB1109848A (en) | New dibenzocycloheptadiene derivatives and process for their preparation | |
| GB932531A (en) | Substituted amides | |
| GB1017264A (en) | Quinazolinone derivatives and the manufacture thereof | |
| GB850483A (en) | Improvements in or relating to pyrimidine derivatives | |
| GB928494A (en) | New quinoxalines | |
| ES425533A1 (en) | Dichlorothiazolylureas processes for their preparation and their use as herbicides | |
| ES314496A1 (en) | Procedure for the preparation of tiazolinic heterociclic derivatives. (Machine-translation by Google Translate, not legally binding) | |
| GB1226251A (en) | ||
| GB852971A (en) | New n-substituted camphidine derivatives and processes for their preparation | |
| GB1298020A (en) | 3-halo-2,6-dinitro-4-trifluoromethylanilines | |
| GB1032253A (en) | Coumarin derivatives and process for the production thereof | |
| JPS5239674A (en) | Imidazole derivatives and agricultural bactericides therefrom | |
| GB1065889A (en) | Improvements in or relating to the production of isoxazole compounds and the products thereof |