GB816426A - Improvements in or relating to vitamin b - Google Patents
Improvements in or relating to vitamin bInfo
- Publication number
- GB816426A GB816426A GB14232/57A GB1423257A GB816426A GB 816426 A GB816426 A GB 816426A GB 14232/57 A GB14232/57 A GB 14232/57A GB 1423257 A GB1423257 A GB 1423257A GB 816426 A GB816426 A GB 816426A
- Authority
- GB
- United Kingdom
- Prior art keywords
- vitamin
- complex
- zinc
- cuprocyanide
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The invention comprises a complex between Vitamin B12 and zinc-cuprocyanide, which is substantially water-insoluble, has a pink colour, is stable to treatment with most common organic solvents, is soluble in dimethyl formamide and may be precipitated from the solution thereof by adding acetone, and may be split up to form Vitamin B12 by treatment with an aqueous solution of a chelating and complexing agent known to give a complex salt with zinc, and a process for the production of highly pure Vitamin B12 which comprises forming zinccuprocyanide in a dilute solution of Vitamin B12 and any associated impurities by reacting a water-soluble cuprocyanide with a water-soluble zinc salt so as to precipitate a zinccuprocyanide Vitamin B12 complex, the remaining material staying in solution and recovering the highly pure Vitamin B12 from the precipitated complex by decomposing the complex. As water-soluble cuprocyanide there may be used tripotassium cuprocyanide which may be reacted with zinc sulphate or zinc acetate. The Vitamin B12 complex may be decomposed by means of a chelating agent such as the sodium salt of ethylene diamino tetra-acetic acid, the sodium salt of N-hydroxy-ethyl-ethylene diamino triacetic acid or the sodium salt of nitrilo triacetic acid in an organic solvent such as amyl alcohol, butyl alcohol, isobutyl alcohol, a phenol or a mixture of phenol with a halogenated hydrocarbon. Subsequently the organic solution of Vitamin B12 is extracted with water and the Vitamin B12 is precipitated by adding another organic solvent in which the Vitamin B12 is insoluble. Examples describe the production of zinc cuprocyanide-Vitamin B12 complex and the recovery of Vitamin B12 from fermentation broth. Specification 816,425 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR816426X | 1956-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB816426A true GB816426A (en) | 1959-07-15 |
Family
ID=9267777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB14232/57A Expired GB816426A (en) | 1956-05-05 | 1957-05-03 | Improvements in or relating to vitamin b |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB816426A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0976757A2 (en) * | 1998-06-11 | 2000-02-02 | Nippon Mitsubishi Oil Corporation | A method of purifying vitamin B12 and/or derivatives thereof |
-
1957
- 1957-05-03 GB GB14232/57A patent/GB816426A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0976757A2 (en) * | 1998-06-11 | 2000-02-02 | Nippon Mitsubishi Oil Corporation | A method of purifying vitamin B12 and/or derivatives thereof |
| EP0976757A3 (en) * | 1998-06-11 | 2001-08-08 | Nippon Mitsubishi Oil Corporation | A method of purifying vitamin B12 and/or derivatives thereof |
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