GB798782A - Anhydrous sterile preparations of alkali barbiturates and alkali thiobarbiturates - Google Patents
Anhydrous sterile preparations of alkali barbiturates and alkali thiobarbituratesInfo
- Publication number
- GB798782A GB798782A GB26312/56A GB2631256A GB798782A GB 798782 A GB798782 A GB 798782A GB 26312/56 A GB26312/56 A GB 26312/56A GB 2631256 A GB2631256 A GB 2631256A GB 798782 A GB798782 A GB 798782A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkali
- barbiturates
- thiobarbiturates
- solution
- barbiturate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Alkali barbiturates and alkali thiobarbiturates are produced in sterile anhydrous form by admixing an aqueous alkaline solution of the barbituric or thiobarbituric acid with about 2 to 10 per cent by weight, with respect to the barbiturate, of a buffer salt such as sodium carbonate or sodium phosphate at a temperature below 10 DEG C., and filtering at this temperature then freeze drying the filtered solution preferably in the ampoules in which the material is ultimately sealed. The starting solution should have a pH of 8 to 12, it may vary, but should be such that solution occurs without hydrolysis of the barbiturates. The concentration of the barbiturate in the starting solution is between 10 to 40 per cent by weight. Other suitable buffer substances that may be used are the citrates of alkali metals and glycine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE798782X | 1955-09-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB798782A true GB798782A (en) | 1958-07-30 |
Family
ID=6711483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB26312/56A Expired GB798782A (en) | 1955-09-01 | 1956-08-28 | Anhydrous sterile preparations of alkali barbiturates and alkali thiobarbiturates |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB798782A (en) |
-
1956
- 1956-08-28 GB GB26312/56A patent/GB798782A/en not_active Expired
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