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GB794798A - Pharmaceutical compositions - Google Patents

Pharmaceutical compositions

Info

Publication number
GB794798A
GB794798A GB27460/56A GB2746056A GB794798A GB 794798 A GB794798 A GB 794798A GB 27460/56 A GB27460/56 A GB 27460/56A GB 2746056 A GB2746056 A GB 2746056A GB 794798 A GB794798 A GB 794798A
Authority
GB
United Kingdom
Prior art keywords
nonionic
ammonium chloride
sodium
anionic
cationic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB27460/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NATHANIEL MANDEL ELIAS
Original Assignee
NATHANIEL MANDEL ELIAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NATHANIEL MANDEL ELIAS filed Critical NATHANIEL MANDEL ELIAS
Publication of GB794798A publication Critical patent/GB794798A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A non-toxic effervescent pharmaceutical composition comprises a solid organic acid material such as tartaric, citric or succinic acid or their potassium or sodium acid salts and a material such as sodium bicarbonate or carbonate which reacts with the organic acid material on contact with moisture to form a gas and a surface-active agent. The surface-active agent may be cationic, anionic, or nonionic. In the first case it should preferably amount by weight to not more than 0.2 per cent of the composition; in the second, not more than 2 per cent; in the third, not more than 25 per cent. A mixture of cationic and nonionic or anionic and nonionic surface-active agents may be used. The pH of the dissolved composition in water should be from 2 to 10 and preferably 3 to 7. Specified surface-active agents are (a) cationic: coconut alkyl dimethylbenzyl ammonium chloride, cetyl trimethyl ammonium chloride, dodecyl dimethylallyl ammonium chloride, cetyl dimethylbenzyl ammonium chloride; (b) anionic: sodium lauryl sulphate, sodium hepta-decyl sulphate; (c) nonionic: the polyethylene glycol mono ester of ricinoleic acid or lauric acid, lauryl ether of polyalkoxyethanol, p-diisobutyl or p-triisopropyl phenoxypolyethoxyethanol having approximately 9 to 11 ethoxy groups. Therapeutic agents may be added for their specific effect: specified are propylparahydroxybenzoate, oxyquinoline sulphate, procaine hydrochloride, butethamine formate and hydrochloride, sulphacetamide, p-nitrosulphathiazole, bacitracin, aureomycin hydrochloride, potassium penicillin. Diluents such as starch and sucrose may be added and the composition may be tabletted. Many examples are given.
GB27460/56A 1955-09-22 1956-09-07 Pharmaceutical compositions Expired GB794798A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US794798XA 1955-09-22 1955-09-22

Publications (1)

Publication Number Publication Date
GB794798A true GB794798A (en) 1958-05-07

Family

ID=22150831

Family Applications (1)

Application Number Title Priority Date Filing Date
GB27460/56A Expired GB794798A (en) 1955-09-22 1956-09-07 Pharmaceutical compositions

Country Status (1)

Country Link
GB (1) GB794798A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1179335B (en) * 1959-03-13 1964-10-08 Therapeutique Lab Franc De Process to increase and extend the duration of action of drug dragees
FR2035119A1 (en) * 1969-03-20 1970-12-18 Pfizer
CN105997924A (en) * 2016-07-07 2016-10-12 驻马店华中正大有限公司 Chlortetracycline hydrochloride effervescent tablets and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1179335B (en) * 1959-03-13 1964-10-08 Therapeutique Lab Franc De Process to increase and extend the duration of action of drug dragees
FR2035119A1 (en) * 1969-03-20 1970-12-18 Pfizer
CN105997924A (en) * 2016-07-07 2016-10-12 驻马店华中正大有限公司 Chlortetracycline hydrochloride effervescent tablets and preparation method thereof

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