GB777517A - Manufacture of nicotinamide - Google Patents
Manufacture of nicotinamideInfo
- Publication number
- GB777517A GB777517A GB11357/55A GB1135755A GB777517A GB 777517 A GB777517 A GB 777517A GB 11357/55 A GB11357/55 A GB 11357/55A GB 1135755 A GB1135755 A GB 1135755A GB 777517 A GB777517 A GB 777517A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nicotinamide
- cyanopyridine
- hydrolysis
- unreacted
- recovered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Nicotinamide is prepared by hydrolysing 3-cyanopyridine at elevated temperatures in an aqueous medium containing as a catalyst a compound having a solubility in water of not more than 0.1 per cent at 20 DEG C. and whose saturated aqueous solution at the same temperature has a pH value between 8 and 11, terminating the reaction when not more than 80 per cent of the 3-cyanopyridine is converted into nicotinamide and recovering nicotinamide and unreacted 3-cyanopyridine from the reaction mixture. The hydrolysis is preferably conducted at a temperature within the range 100 DEG to 130 DEG C. Specified hydrolysis catalysts are magnesium oxide, calcium carbonate and barium carbonate. The nicotinamide may be recovered by distillation and extraction of the residue with acetone. The distillate containing the unreacted 3-cyanopyridine may be passed through an ion-exchange resin to remove ammonia and the resulting solution recycled to the hydrolysis process. The nicotinamide may also be recovered by direct extraction of the aqueous reaction mixture with benzene, toluene, carbon tetrachloride, petroleum ether or chloroform. In the Provisional Specification, magnesium carbonate is also specified as a hydrolysis catalyst. Specification 563,184, [Group IV], is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB11357/55A GB777517A (en) | 1955-04-20 | 1955-04-20 | Manufacture of nicotinamide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB11357/55A GB777517A (en) | 1955-04-20 | 1955-04-20 | Manufacture of nicotinamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB777517A true GB777517A (en) | 1957-06-26 |
Family
ID=9984773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB11357/55A Expired GB777517A (en) | 1955-04-20 | 1955-04-20 | Manufacture of nicotinamide |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB777517A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114436953A (en) * | 2021-10-29 | 2022-05-06 | 陕西菲尔特化工有限公司 | Synthesis process of 3-aminopyridine |
-
1955
- 1955-04-20 GB GB11357/55A patent/GB777517A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114436953A (en) * | 2021-10-29 | 2022-05-06 | 陕西菲尔特化工有限公司 | Synthesis process of 3-aminopyridine |
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