GB643268A - Improved process for the preparation of prolonged effect insulin products - Google Patents
Improved process for the preparation of prolonged effect insulin productsInfo
- Publication number
- GB643268A GB643268A GB34626/45A GB3462645A GB643268A GB 643268 A GB643268 A GB 643268A GB 34626/45 A GB34626/45 A GB 34626/45A GB 3462645 A GB3462645 A GB 3462645A GB 643268 A GB643268 A GB 643268A
- Authority
- GB
- United Kingdom
- Prior art keywords
- insulin
- preparation
- salmiridine
- protein
- addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A crystalline insulin preparation having a prolonged therapeutic effect comprises insulin, a zinc salt, an alkaline protein or protein split product, and a phenol or phenol derivative mixed together in aqueous medium in approximately isophanous conditions (i.e. such that after the removal of the insulin complex from preparations of the above type, the addition of insulin to one portion of the residual liquor and of alkaline protein to the other, produces the same degree of opalescence in both portions) at a pH of 6-8, preferably in the presence of a buffer such as sodium phosphate or acetate. Crystallization is improved in the presence of inorganic salts such as sodium chloride, which may be added to produce an isotonic preparation. Alternatively, an excess of such salt may be used and isotonicity produced by the addition of e.g. glucose. Specified proteins are salmiridine, clupeine, scombrine, sturine, thynnine, cyprinine, cyclopterine, a split product of salmiridine and thymus histone. Suitable phenols are o-, m-, p-cresol; m-, p-, chlorophenol; m-, p-nitrophenol and resorcin.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK643268X | 1944-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB643268A true GB643268A (en) | 1950-09-15 |
Family
ID=8151959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB34626/45A Expired GB643268A (en) | 1944-04-04 | 1945-12-20 | Improved process for the preparation of prolonged effect insulin products |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB643268A (en) |
| MY (1) | MY5300087A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE948279C (en) * | 1951-03-02 | 1956-08-30 | Novo Terapeutisk Labor As | Process for the production of insulin crystals with an increased metal content |
| DE1044360B (en) * | 1953-08-19 | 1958-11-20 | Roskilde Medical Company Ltd R | Process for the production of zinc insulin with an increased zinc content |
| EP1585771A1 (en) * | 2002-12-31 | 2005-10-19 | Altus Pharmaceuticals Inc. | Complexes of protein crystals and ionic polymers |
| US9376479B2 (en) | 2002-12-31 | 2016-06-28 | Anjinomoto Althea, Inc. | Human growth hormone crystals and methods for preparing them |
-
1945
- 1945-12-20 GB GB34626/45A patent/GB643268A/en not_active Expired
-
1953
- 1953-12-31 MY MY5300087A patent/MY5300087A/en unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE948279C (en) * | 1951-03-02 | 1956-08-30 | Novo Terapeutisk Labor As | Process for the production of insulin crystals with an increased metal content |
| DE1044360B (en) * | 1953-08-19 | 1958-11-20 | Roskilde Medical Company Ltd R | Process for the production of zinc insulin with an increased zinc content |
| EP1585771A1 (en) * | 2002-12-31 | 2005-10-19 | Altus Pharmaceuticals Inc. | Complexes of protein crystals and ionic polymers |
| EP1585771A4 (en) * | 2002-12-31 | 2006-11-29 | Altus Pharmaceuticals Inc | Complexes of protein crystals and ionic polymers |
| AU2003300126B2 (en) * | 2002-12-31 | 2010-04-01 | Altus Pharmaceuticals Inc. | Complexes of protein crystals and ionic polymers |
| US9376479B2 (en) | 2002-12-31 | 2016-06-28 | Anjinomoto Althea, Inc. | Human growth hormone crystals and methods for preparing them |
Also Published As
| Publication number | Publication date |
|---|---|
| MY5300087A (en) | 1953-12-31 |
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