GB626405A - Improvements in or relating to the purification of penicillin salts - Google Patents
Improvements in or relating to the purification of penicillin saltsInfo
- Publication number
- GB626405A GB626405A GB1435547A GB1435547A GB626405A GB 626405 A GB626405 A GB 626405A GB 1435547 A GB1435547 A GB 1435547A GB 1435547 A GB1435547 A GB 1435547A GB 626405 A GB626405 A GB 626405A
- Authority
- GB
- United Kingdom
- Prior art keywords
- extraction
- butyl alcohol
- penicillin
- water
- aqueous phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/14—Preparation of salts
- C07D499/16—Preparation of salts of alkali or alkaline earth metals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Penicillin salts are purified by alternate extractions from aqueous solutions into an aliphatic alcohol of 4 or 5 carbon atoms or a mixture of these compounds and from organic solvent solutions into water at a pH of 4.5-8.0, preferably in the range 6.0-8.0 The process may suitably be applied to the ammonium, substituted ammonium, sodium, potassium and rubidium salts of penicillin. The process may be used to effect partial separation of salts of the individual penicillins, e.g. on extraction from an aqueous phase to an organic solvent phase penicillin X remains in the aqueous phase and on re-extraction with water penicillin K remains in the organic solvent. The extraction may be performed by continuous counter-current methods. When the solvent is butyl alcohol a ratio of butyl alcohol to aqueous phase of between 1 : 1 and 4 : 1 suitably between 2.0 : 1 and 1 : 1 is used for extraction from the aqueous phase and a ratio of water to butyl alcohol of less than 1 : 1, preferably between .03 : 1 and 1 : 1 is used for extraction from the butyl alcohol phase. In examples, solutions of sodium, ammonium, potassium and calcium penicillins are extracted successively with butyl alcohol and water giving in some cases partial separation of the various penicillins. The Provisional Specification describes also the use in the process of the present invention of organic solvents in general.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1435547A GB626405A (en) | 1947-05-30 | 1947-05-30 | Improvements in or relating to the purification of penicillin salts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1435547A GB626405A (en) | 1947-05-30 | 1947-05-30 | Improvements in or relating to the purification of penicillin salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB626405A true GB626405A (en) | 1949-07-14 |
Family
ID=10039701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1435547A Expired GB626405A (en) | 1947-05-30 | 1947-05-30 | Improvements in or relating to the purification of penicillin salts |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB626405A (en) |
-
1947
- 1947-05-30 GB GB1435547A patent/GB626405A/en not_active Expired
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