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GB611080A - Improvements in or relating to chromatographic separation - Google Patents

Improvements in or relating to chromatographic separation

Info

Publication number
GB611080A
GB611080A GB662446A GB662446A GB611080A GB 611080 A GB611080 A GB 611080A GB 662446 A GB662446 A GB 662446A GB 662446 A GB662446 A GB 662446A GB 611080 A GB611080 A GB 611080A
Authority
GB
United Kingdom
Prior art keywords
chamber
walls
jack
annular
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB662446A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHARLES GABRIEL LYNAM
HERBERT WEIL
Original Assignee
CHARLES GABRIEL LYNAM
HERBERT WEIL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHARLES GABRIEL LYNAM, HERBERT WEIL filed Critical CHARLES GABRIEL LYNAM
Priority to GB662446A priority Critical patent/GB611080A/en
Publication of GB611080A publication Critical patent/GB611080A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/6069—Construction of the column body with compartments or bed substructure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N2030/165—Injection retention gaps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/381—Flow patterns centrifugal chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/386—Radial chromatography, i.e. with mobile phase traversing radially the stationary phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8411—Intermediate storage of effluent, including condensation on surface
    • G01N2030/8417—Intermediate storage of effluent, including condensation on surface the store moving as a whole, e.g. moving wire
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/58—Conditioning of the sorbent material or stationary liquid the sorbent moving as a whole
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6021—Adjustable pistons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/606—Construction of the column body with fluid access or exit ports
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/80—Fraction collectors
    • G01N30/82—Automatic means therefor

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

An apparatus for chromatographically separating substances from one another comprises a container, a material in the container which is chromatographically active with respect to at least one of the substances, and means for mechanically segregating a region of the material from the remainder thereof. An apparatus intended for radial chromatography (Fig. 2) comprises a chamber 7 filled with chromatographically active material, an annular portion 10 thereof in which the <PICT:0611080/III/1> <PICT:0611080/III/2> recovered concentrates being separated from the remainder by two coaxial cylindrical perforated walls 11 and 12 interconnected by a removable bottom 13 and a removable lid 23. The bottom 13 stands on a support 14 carried by jacks 15. The material is recovered by unlocking the lid 23 and raising the jacks 15, whereby the chamber containing the annular portion 10 is raised to a position above the chamber 7 where it can be replaced by another charged chamber. A plurality of such removable annular portions may be provided. According to a modification (Fig. 9, not shown), the perforated walls are attached to the walls of the support, but are not connected to the bottom. On raising the jack, the material in the annular zone is isolated by the walls of the support and is eluted, the elutant being drawn off by a tap provided in the bottom. Alternatively (Fig. 5, not shown), this embodiment may be modified by resting a second annular chamber, the walls of which have sharpened upper edges, below the first chamber on a support carried by a second jack. On raising the second jack, the sharpened edges cut through the material in the first annular chamber and the first jack is then operated as before. According to another modification, Fig. 11, chambers 61, 62, 63 and 64 carrying the chromatographic material are laterally removable into staggered relationship on horizontal rail guides for replacement by stand-by chambers 611, 621, 631 and 641. The apparatus may be charged with a material carrying a chromatographically active liquid on only a part thereof. Specification 585,224 is referred to.
GB662446A 1946-03-04 1946-03-04 Improvements in or relating to chromatographic separation Expired GB611080A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB662446A GB611080A (en) 1946-03-04 1946-03-04 Improvements in or relating to chromatographic separation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB662446A GB611080A (en) 1946-03-04 1946-03-04 Improvements in or relating to chromatographic separation

Publications (1)

Publication Number Publication Date
GB611080A true GB611080A (en) 1948-10-25

Family

ID=9817851

Family Applications (1)

Application Number Title Priority Date Filing Date
GB662446A Expired GB611080A (en) 1946-03-04 1946-03-04 Improvements in or relating to chromatographic separation

Country Status (1)

Country Link
GB (1) GB611080A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2678132A (en) * 1950-03-31 1954-05-11 Socony Vacuum Oil Co Inc Endless belt adsorption
WO2006021203A1 (en) * 2004-08-25 2006-03-02 Analyticon Discovery Gmbh Method and device for separating mixtures

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2678132A (en) * 1950-03-31 1954-05-11 Socony Vacuum Oil Co Inc Endless belt adsorption
WO2006021203A1 (en) * 2004-08-25 2006-03-02 Analyticon Discovery Gmbh Method and device for separating mixtures

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