GB533513A - Process of obtaining a purified vitamin k preparation - Google Patents
Process of obtaining a purified vitamin k preparationInfo
- Publication number
- GB533513A GB533513A GB2312939A GB2312939A GB533513A GB 533513 A GB533513 A GB 533513A GB 2312939 A GB2312939 A GB 2312939A GB 2312939 A GB2312939 A GB 2312939A GB 533513 A GB533513 A GB 533513A
- Authority
- GB
- United Kingdom
- Prior art keywords
- vitamin
- petroleum ether
- decalso
- permutit
- extracted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940046010 vitamin k Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- FVIGODVHAVLZOO-UHFFFAOYSA-N Dixanthogen Chemical compound CCOC(=S)SSC(=S)OCC FVIGODVHAVLZOO-UHFFFAOYSA-N 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 10
- 239000003208 petroleum Substances 0.000 abstract 5
- JYIMWRSJCRRYNK-UHFFFAOYSA-N dialuminum;disodium;oxygen(2-);silicon(4+);hydrate Chemical compound O.[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Na+].[Na+].[Al+3].[Al+3].[Si+4] JYIMWRSJCRRYNK-UHFFFAOYSA-N 0.000 abstract 4
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 abstract 3
- 229930003231 vitamin Natural products 0.000 abstract 3
- 229940088594 vitamin Drugs 0.000 abstract 3
- 235000013343 vitamin Nutrition 0.000 abstract 3
- 239000011782 vitamin Substances 0.000 abstract 3
- PFRQBZFETXBLTP-RCIYGOBDSA-N 2-[(2e,6e,10e,14e,18e)-3,7,11,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-1-yl]-3-methyl-1,4-dihydronaphthalene-1,4-dione Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(=O)C2=C1 PFRQBZFETXBLTP-RCIYGOBDSA-N 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 abstract 2
- 229930003448 Vitamin K Natural products 0.000 abstract 2
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 abstract 2
- 238000001179 sorption measurement Methods 0.000 abstract 2
- 238000005292 vacuum distillation Methods 0.000 abstract 2
- 235000019168 vitamin K Nutrition 0.000 abstract 2
- 239000011712 vitamin K Substances 0.000 abstract 2
- 150000003721 vitamin K derivatives Chemical class 0.000 abstract 2
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 2
- 229940010250 vitamin k 2 Drugs 0.000 abstract 2
- 229910018072 Al 2 O 3 Inorganic materials 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 235000019733 Fish meal Nutrition 0.000 abstract 1
- 241000219823 Medicago Species 0.000 abstract 1
- 240000004658 Medicago sativa Species 0.000 abstract 1
- 241001125048 Sardina Species 0.000 abstract 1
- 229910004298 SiO 2 Inorganic materials 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 230000002364 anti-haemorrhagic effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003610 charcoal Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000004467 fishmeal Substances 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 235000012054 meals Nutrition 0.000 abstract 1
- 235000019512 sardine Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
533,513. Vitamins. JACKSON, L. MELLERSH.- (St. Louis University, President & Board of Trustees of). Aug. 10, 1939, No. 23129. [Class 2 (iii)] The anti-haemorrhagic vitamin K is concentrated by adsorption in a base-exchange silicate and description by a solvent and further concentration may be effected by repeating the process with the same or a different adsorbent such as carbon or by high vacuum distillation or crystallization. Vitamin K is said to comprise two distinct chemically related bodies, K, obtained by strongly chilling an acetone or alcohol solution of the vitamin from alfalfa, and K 2 obtained from putrified fish meal. The base exchange silicate known as Decalso (Na 2 O : Al 2 O 3 : SiO 2 = 1 : 1 : 6) is preferred for the first concentration and the silicate sold under the Registered Trade Mark "Permutit" is preferred for further fractionation and for isolating vitamin K 2 . In examples (1) Alfalfa is extracted with petroleum ether and the extract is passed through a column of Decalso, the column then being washed with four portions of petroleum ether, the third and fourth washings which contain most of the vitamin being then further fractionated with Decalso or "Permutit"; still further concentration may be effected by adsorption on "Permutit" or charcoal or by high vacuum distillation ; (2) Sardine meal is extracted with isopropyl ether, dried, moistened with water and putrefied at 35‹C. for two or three weeks ; the product is dried and extracted with petroleum ether, the residue being caused to putrefy a second and subsequently a third time ; the extract is adsorbed on Decalso and desorbed by petroleum ether and benzene-petroleum ether, yielding vitamin K 2 . Specification 527,798 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2312939A GB533513A (en) | 1939-08-10 | 1939-08-10 | Process of obtaining a purified vitamin k preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2312939A GB533513A (en) | 1939-08-10 | 1939-08-10 | Process of obtaining a purified vitamin k preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB533513A true GB533513A (en) | 1941-02-14 |
Family
ID=10190597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2312939A Expired GB533513A (en) | 1939-08-10 | 1939-08-10 | Process of obtaining a purified vitamin k preparation |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB533513A (en) |
-
1939
- 1939-08-10 GB GB2312939A patent/GB533513A/en not_active Expired
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