GB2634841A - Systems and methods for preparing vaccines utilizing predictably inactivated pathogens - Google Patents
Systems and methods for preparing vaccines utilizing predictably inactivated pathogens Download PDFInfo
- Publication number
- GB2634841A GB2634841A GB2500264.3A GB202500264A GB2634841A GB 2634841 A GB2634841 A GB 2634841A GB 202500264 A GB202500264 A GB 202500264A GB 2634841 A GB2634841 A GB 2634841A
- Authority
- GB
- United Kingdom
- Prior art keywords
- pathogenic
- source
- compartment
- neutered
- pathogenic source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract 21
- 229960005486 vaccine Drugs 0.000 title claims abstract 3
- 244000052769 pathogen Species 0.000 title 1
- 230000001717 pathogenic effect Effects 0.000 claims abstract 29
- 241000700605 Viruses Species 0.000 claims abstract 5
- 239000002054 inoculum Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 230000037361 pathway Effects 0.000 claims 2
- 102000053723 Angiotensin-converting enzyme 2 Human genes 0.000 claims 1
- 108090000975 Angiotensin-converting enzyme 2 Proteins 0.000 claims 1
- 101710091045 Envelope protein Proteins 0.000 claims 1
- 108090001074 Nucleocapsid Proteins Proteins 0.000 claims 1
- 101710188315 Protein X Proteins 0.000 claims 1
- 102100021696 Syncytin-1 Human genes 0.000 claims 1
- 238000011166 aliquoting Methods 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000003928 nasal cavity Anatomy 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 229960004854 viral vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/01—Deodorant compositions
- A61L9/014—Deodorant compositions containing sorbent material, e.g. activated carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/16—Disinfection, sterilisation or deodorisation of air using physical phenomena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/16—Disinfection, sterilisation or deodorisation of air using physical phenomena
- A61L9/18—Radiation
- A61L9/20—Ultraviolet radiation
-
- A—HUMAN NECESSITIES
- A62—LIFE-SAVING; FIRE-FIGHTING
- A62B—DEVICES, APPARATUS OR METHODS FOR LIFE-SAVING
- A62B11/00—Devices for reconditioning breathing air in sealed rooms
-
- A—HUMAN NECESSITIES
- A62—LIFE-SAVING; FIRE-FIGHTING
- A62B—DEVICES, APPARATUS OR METHODS FOR LIFE-SAVING
- A62B23/00—Filters for breathing-protection purposes
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F13/00—Details common to, or for air-conditioning, air-humidification, ventilation or use of air currents for screening
- F24F13/28—Arrangement or mounting of filters
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F8/00—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying
- F24F8/10—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by separation, e.g. by filtering
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F8/00—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying
- F24F8/20—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by sterilisation
- F24F8/22—Treatment, e.g. purification, of air supplied to human living or working spaces otherwise than by heating, cooling, humidifying or drying by sterilisation using UV light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
- A61L2209/10—Apparatus features
- A61L2209/14—Filtering means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
- A61L2209/10—Apparatus features
- A61L2209/16—Connections to a HVAC unit
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F13/00—Details common to, or for air-conditioning, air-humidification, ventilation or use of air currents for screening
- F24F13/08—Air-flow control members, e.g. louvres, grilles, flaps or guide plates
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Combustion & Propulsion (AREA)
- Emergency Management (AREA)
- Business, Economics & Management (AREA)
- Materials Engineering (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
A method is described for producing a vaccine from a neutered pathogenic source. The neutered pathogenic source may be a SARS-COV-2 virus that is neutered with a defined dose of UV-C light. The neutered SARS-COV-2 viral vaccine is administered through an inhalation pump. The architecture of the neutered inactivated virus can be kept intact or partially destroyed by using graded dosage of the UVC.
Claims (23)
1. A method for producing a vaccine comprising: (a) standardizing a pathogenic source to a known quantity and activity; (b) determining a dosage of UV-C needed to neuter the pathogenic source; and (c) aliquoting the neutered pathogenic source into containers.
2. The method as claimed in claim 1, wherein the pathogenic source is a virus.
3. The method as claimed in claim 1, wherein the pathogenic source is neutered in a disinfectant unit comprising a housing that is opaque to UVC and enclosing a chamber that has: (a) a chamber wall that is transparent to UV-C light; (b) a chamber inlet; (c) a chamber outlet; (d) a centralized inner bore having an interior chamber surface facing the inner bore; (e) a UV-C light source positioned adjacent the interior surface; and (f) a helical air flow diverter centralized within the inner bore proximal the UV-C light source, wherein the helical airflow diverter creates a helical path for the airflow pathway as the airflow pathway proceeds from the housing inlet to the housing outlet.
4. The method as claimed in claim 3, wherein the pathogenic source is a SARS-COV-2 virus.
5. The method as claimed in claim 1, wherein an aliquot of the neutered pathogenic source is injected into an inhalation pump.
6. The method as claimed in claim 5, wherein the aliquot of the neutered pathogenic source is injected into a first and a second upper compartment of the inhalation pump.
7. The method as claimed in claim 1, wherein an aliquot of the neutered pathogenic source is injected into a syringe.
8. The method as claimed in claim 5, wherein the inhalation pump comprises: (a) a first half and a second half, wherein each half has a top compartment and an adjoining bottom compartment; (b) a fill line associated with each half, the fill line having a septum on a bottom end and a top end that enters a central bore in the top compartment; (c) each bottom compartment is filled with compressed air and has a moveable bottom end opposite to the adjoined top compartment; and (d) each top compartment has a releasable cap at a top end opposite to the adjoined bottom compartment.
9. The method as claimed in claim 1, further comprising administering an aliquot of the neutered pathogenic source to a patient by an intramuscular, subcutaneous, or intravenous injection.
10. The method as claimed in claim 1, further comprising orally administering an aliquot of the neutered pathogenic source to a patient.
11. The method as claimed in claim 10, wherein an aliquot of the neutered pathogenic source is administered in a tablet or a liquid form.
12. The method as claimed in claim 1, further comprising administering an aliquot of the neutered pathogenic source to an animal through an inhalation, injection, or oral route.
13. An inhalation pump comprising: (a) a first half and a second half, wherein each half has a top compartment and an adjoining bottom compartment; (b) a fill line associated with each half, the fill line having a septum on a bottom end and a top end that enters a central bore in the top compartment; (c) each bottom compartment is filled with compressed air and has a moveable bottom end opposite to the adjoined top compartment; and (d) each top compartment has a releasable cap at a top end opposite to the adjoined bottom compartment.
14. The inhalation pump as claimed in claim 13, wherein each top compartment is curved backwards about 40 to 60 degrees.
15. The inhalation pump as claimed in claim 13, wherein the moveable bottom end is attachable to a syringe.
16. A method of administering a neutered pathogenic inoculum into a nasal cavity of a patient comprising: (a) preparing a neutered pathogenic inoculum; (b) loading the neutered pathogenic inoculum into a central bore of a top compartment of an inhalation pump, wherein the top compartment has a top end that is capped with a removable cap and a moveable bottom end that adjoins a bottom compartment; (c) filling the bottom compartment with a compressed air, wherein the bottom compartment has a moveable bottom end opposite to the adjoined top compartment; (d) attaching a top end of a syringe to the moveable bottom end of the bottom compartment; (e) removing the cap from the top end of the top compartment; and (f) pushing a plunger at a bottom end of the syringe upward to force the inoculum into a patientâ s nostril.
17. A method of quantitating damage to a pathogenic source comprising: (a) preparing a standardized pathogenic source; (b) treating the pathogenic source with a known dosage of UV-C radiation; (c) collecting the UV-C treated pathogenic source; (d) assessing an amount of damage to a genetic material of the UV-C treated pathogenic source; and (e) assessing an amount of damage to one or more proteins of the UV-C treated pathogenic source.
18. The method as claimed in claim 17, further comprising treating the pathogenic source with varying dosages of UV-C.
19. The method as claimed in claim 18, wherein the amount of damage to the genetic material and to one or more proteins of the pathogenic source is correlated to the dosage of UV- C used to treat the pathogenic source.
20. The method as claimed in claim 19, wherein the pathogenic source is a SARS-COV-2 virus.
21 . The method as claimed in claim 20, wherein a dosage of UV-C is selected that neuters the SARS-COV-2 source without destroying a nucleocapsid protein or an envelope protein.
22. The method as claimed in claim 21, wherein a dosage of UV-C is selected that retains the ability of the neutered SARS-COV-2 source to engage an ACE2 receptor.
23. The method as claimed in claim 17, wherein the pathogenic source is treated in a plurality of disinfection units.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263353369P | 2022-06-17 | 2022-06-17 | |
| US202263359381P | 2022-07-08 | 2022-07-08 | |
| US202263401817P | 2022-08-29 | 2022-08-29 | |
| US18/058,185 US11951164B2 (en) | 2021-08-16 | 2022-11-22 | Systems and methods for the preparation of vaccines utilizing predictably inactivated pathogens |
| US18/328,463 US12194206B2 (en) | 2021-08-16 | 2023-06-02 | Expandable system for purification and disinfection of air |
| PCT/US2023/068541 WO2023245140A2 (en) | 2022-06-17 | 2023-06-15 | Systems and methods for the preparation of vaccines utilizing predictably inactivated pathogens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB202500264D0 GB202500264D0 (en) | 2025-02-26 |
| GB2634841A true GB2634841A (en) | 2025-04-23 |
Family
ID=89191999
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2500264.3A Pending GB2634841A (en) | 2022-06-17 | 2023-06-15 | Systems and methods for preparing vaccines utilizing predictably inactivated pathogens |
| GB2418225.5A Pending GB2634432A (en) | 2022-06-17 | 2023-06-15 | Expandable system for purification and disinfection of air |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2418225.5A Pending GB2634432A (en) | 2022-06-17 | 2023-06-15 | Expandable system for purification and disinfection of air |
Country Status (2)
| Country | Link |
|---|---|
| GB (2) | GB2634841A (en) |
| WO (2) | WO2023245138A1 (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5989217A (en) * | 1996-03-21 | 1999-11-23 | Unisia Jecs Corporation | Medicine administering device for nasal cavities |
| US20120211525A1 (en) * | 2009-10-22 | 2012-08-23 | Mahbobeh Taghinejad Sadabadi | Dosing-device |
| US20170121701A1 (en) * | 2015-10-30 | 2017-05-04 | Sensor Electronic Technology, Inc. | Vaccine Preparation Using Ultraviolet Radiation |
| US11052169B1 (en) * | 2020-05-08 | 2021-07-06 | Perumala Holdings, LLC | Systems, apparatus and methods for purifying air |
| US20210299291A1 (en) * | 2020-03-29 | 2021-09-30 | Dynamics Inc. | Systems and methods for uv-c inactivated virus vaccines and uv-c sanitization |
| DE102021003829A1 (en) * | 2020-09-06 | 2022-04-21 | Kastriot Merlaku | Vaccine Generator |
| US20230081767A1 (en) * | 2021-08-16 | 2023-03-16 | Madhavan Pisharodi | Systems and methods for the preparation of vaccines utilizing predictably inactivated pathogens |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8066791B2 (en) * | 2007-07-20 | 2011-11-29 | Donaldson Company, Inc. | Air cleaner arrangements with internal and external support for cartridge; components; and, methods |
| EP2327466B1 (en) * | 2009-11-12 | 2014-08-06 | Novomatic AG | Air cleaner for removing air pollutants from an air stream |
| US20110136467A1 (en) * | 2009-12-08 | 2011-06-09 | Muir Iii Brockett | Communication Link Connection Indication Signal Method and Apparatus Employing Promotional Content |
| DE202010007120U1 (en) * | 2010-05-21 | 2011-09-07 | Novomatic Ag | Cooling air cleaner of an electronic device |
| US11511013B2 (en) * | 2020-05-08 | 2022-11-29 | Madhavan Pisharodi | Air purification and disinfection apparatus and methods of use |
-
2023
- 2023-06-15 GB GB2500264.3A patent/GB2634841A/en active Pending
- 2023-06-15 WO PCT/US2023/068538 patent/WO2023245138A1/en not_active Ceased
- 2023-06-15 GB GB2418225.5A patent/GB2634432A/en active Pending
- 2023-06-15 WO PCT/US2023/068541 patent/WO2023245140A2/en not_active Ceased
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5989217A (en) * | 1996-03-21 | 1999-11-23 | Unisia Jecs Corporation | Medicine administering device for nasal cavities |
| US20120211525A1 (en) * | 2009-10-22 | 2012-08-23 | Mahbobeh Taghinejad Sadabadi | Dosing-device |
| US20170121701A1 (en) * | 2015-10-30 | 2017-05-04 | Sensor Electronic Technology, Inc. | Vaccine Preparation Using Ultraviolet Radiation |
| US20210299291A1 (en) * | 2020-03-29 | 2021-09-30 | Dynamics Inc. | Systems and methods for uv-c inactivated virus vaccines and uv-c sanitization |
| US11052169B1 (en) * | 2020-05-08 | 2021-07-06 | Perumala Holdings, LLC | Systems, apparatus and methods for purifying air |
| DE102021003829A1 (en) * | 2020-09-06 | 2022-04-21 | Kastriot Merlaku | Vaccine Generator |
| US20230081767A1 (en) * | 2021-08-16 | 2023-03-16 | Madhavan Pisharodi | Systems and methods for the preparation of vaccines utilizing predictably inactivated pathogens |
Non-Patent Citations (1)
| Title |
|---|
| Natrure - Scientific Reports, 5 July 2021, C-W Lo et al., "UVC disinfects SARS-CoV-2 by induction of viral genome damage without apparent effects on viral morphology and proteins", pages 1-11 * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2634432A (en) | 2025-04-09 |
| WO2023245140A2 (en) | 2023-12-21 |
| WO2023245140A3 (en) | 2024-03-14 |
| GB202418225D0 (en) | 2025-01-29 |
| WO2023245138A1 (en) | 2023-12-21 |
| GB202500264D0 (en) | 2025-02-26 |
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