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GB2632396A - Liquid metering dispensing apparatus and method of operating thereof - Google Patents

Liquid metering dispensing apparatus and method of operating thereof Download PDF

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Publication number
GB2632396A
GB2632396A GB2310987.9A GB202310987A GB2632396A GB 2632396 A GB2632396 A GB 2632396A GB 202310987 A GB202310987 A GB 202310987A GB 2632396 A GB2632396 A GB 2632396A
Authority
GB
United Kingdom
Prior art keywords
valve
cavity
liquid
reservoir
heating chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB2310987.9A
Other versions
GB202310987D0 (en
Inventor
Mcgrattan Peter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Athos Medical Tech Ltd
Original Assignee
Athos Medical Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Athos Medical Tech Ltd filed Critical Athos Medical Tech Ltd
Priority to GB2310987.9A priority Critical patent/GB2632396A/en
Publication of GB202310987D0 publication Critical patent/GB202310987D0/en
Priority to PCT/GB2024/051787 priority patent/WO2025017280A1/en
Publication of GB2632396A publication Critical patent/GB2632396A/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/10—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation
    • G01F11/12—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements
    • G01F11/14—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements wherein the measuring chamber reciprocates
    • G01F11/16—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements wherein the measuring chamber reciprocates for liquid or semiliquid
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/48—Fluid transfer means, e.g. pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008—Electronic counters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
    • B65D83/52—Metering valves; Metering devices
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/10—Devices using liquid inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/48—Fluid transfer means, e.g. pumps
    • A24F40/485—Valves; Apertures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

A liquid dispensing apparatus for dispensing a metered liquid has a heating chamber 3 having an internal cavity 20 determining or defining a metered dose of the liquid. An electrical heating coil 4 is arranged to heat the chamber and a normally closed first valve 30 is located at an inlet of the cavity and a normally closed second valve 31 is located at an outlet of the cavity. A reservoir 1 for the liquid 40 has a member 5 arranged to open the first valve 30. The heating chamber is reciprocally mounted with respect to the reservoir so that motion of the heating chamber toward the reservoir brings the first valve into contact with the member to open the first valve. A differential pressure-drop causes liquid to flow into the cavity. Motion in an opposing direction causes the first valve to close and the heating coil to activate to vaporizing liquid in the cavity. Provision of a negative pressure on the cavity then causes the second valve to open so that vapor is sucked out of the cavity.

Description

LIQUID METERING DISPENSING APPARATUS AND METHOD OF OPERATING THEREOF
This invention relates to a liquid metering dispensing apparatus and method of operating thereof, and, in particular, although not exclusively, for use as an inhaler or vaping device.
With a medicinal inhaler or personal vaporizer, it is required to dispense a precise, metered, quantity of a liquid.
It is known from US-A-7222755 to provide a liquid metered dispensing squeezable bottle containing a dip tube and a one-way valve system at the bottom of the dip tube. The dip tube includes a leg that is flexible to permit folding of the leg toward the container for insertion into a standard neck or narrow neck container.
US-A-7040513 discloses a valve body and a valve member which is slidably mounted within the body between rest and dispensing positions. The valve has a metering chamber to contain a metered quantity of liquid each time the valve is activated, the valve being formed by a diagonal hole with the valve member.
The present invention seeks to provide an apparatus in which a uniform dose is metered from a liquid reservoir and to prevent thermal degradation of the metered dose and to prevent the reservoir from exposure to the heating process.
According to one aspect of this invention, there is provided a liquid metering dispensing apparatus for dispensing a metered liquid including a heating chamber having an internal cavity determining a metered dose of said liquid, an electrical heating coil arranged to heat said chamber, a normally closed first valve at an inlet of said cavity and a normally closed second valve at an outlet of said cavity, a reservoir for said liquid having an opening means for said first valve, said heating chamber being reciprocally mounted with respect to said reservoir, whereby, in operation, motion in a first direction of said heating chamber with respect to said reservoir brings said first valve into contact with said opening means to open said first valve, owing to a differential pressure drop liquid is caused to flow into said cavity, motion in a second direction causes said first valve to close, said heating coil is activated to vaporize liquid in said cavity, and provision of a negative pressure on said cavity causes said second valve to open so that vapor is sucked out of said cavity.
Preferably, said heating chamber ncludes a mouth piece having an internal bore accessible by operation of said second valve to communicate with said cavity.
Advantageously, a pair of seals are provided around the heating chamber, each on an opposed side of the heating coil.
Conveniently, the heating coil and the reservoir each have a circular cross-section and the heating coil is formed with a portion about the reservoir.
Preferably, the mouth piece has a portion concentrically formed within said heating chamber and said heating chamber has a cylindrical outer body closed at one end, and spring bias means is interposed between said one end of said reservoir to bias said heating chamber n said second direction.
Advantageously, cooperating releasable captive means are provided between the heating chamber and the reservoir, against which the spring bias means exerts pressure.
Conveniently, the opening means is a member located in said reservoir arranged to contact and open said first valve when the heating chamber is depressed into said reservoir against the force of said spring bias means Conveniently, the spring bias means is a compression spring.
Conveniently, the heating coil includes an energy source arranged to heat an electrical element.
Advantageously, said electrical element is made of an electrically resistive material such as doped ceramics, molybdenum disilicide carbon, graphite, metal, quartz or composite materials made of a ceramic material and a metallic material.
Alternatively, the heating element could be an infrared heating element, a photonic source or an inductive heating element.
Preferably, the heating coil is arranged to convert the metered dose into droplets of 2 -5m crons, or less than 2 microns for systematic absorption.
Advantageously, the heating coil has a temperature in the range 20°C -200°C, usually in the range 30°C -90°C, and, preferably, 60°C.
Advantageously, the liquid is a medicament, or nicotine, plus an excipient including propylene glycol, vegetable glycerine, or an organic solvent such as ethanol.
Conveniently, the heating coil is activated by motion of the heating chamber, or by a manual control, e.g. a button, or by a pressure transducer when a user sucks on the mouthpiece, to vaporize the liquid.
In another aspect of this invention there is provided a method of operating the apparatus of said one aspect, wherein the reservoir contains liquid and including the steps of moving the heating chamber into contact with the opening means to open the first valve, a differential pressure drop causing the liquid to flow into the cavity, moving the heating chamber in the opposite, second direction causing the first valve to close, activating the heating coil to vaporize liquid in the cavity, and providing a negative pressure on the cavity by sucking, causing the second valve to open so that vapor is sucked out of the cavity.
The invention will now be described, by way of example, with reference to the accompanying drawings, in which: Figures 1 -5 show schematic cross-sections of a liquid metering dispensing apparatus in accordance with this invention in differing operational positions thereof, and Figure 6 shows a schematic cross-section of the liquid metering dispensing apparatus with a volume of air that is enclosed prior to expansion during actuation of the apparatus.
In the Figures like reference numerals denote like parts.
Figure I shows the liquid metering dispensing apparatus in a rest position as it would normally be supplied to a user. A reservoir 1 is formed by a cylinder having a closed end 2 and an open end through which is reciprocally mounted an assembly formed by a heating chamber 3 and a mouthpiece 4. The closed end of the reservoir has an upstanding member 5 which may have an upper end in the form of a triangularly shaped transverse portion or a pointed upper end 6, the reservoir containing a liquid which may be a medicament for administration to a user. The medicament, or nicotine, may be plus an exc ment including propylene glycol, vegetable glycerine, or an organic solvent such as ethanol. The excipients may be [100/0 PG/VG or VG/PG] to [50/50 PG/VG] & include up to 30% ethanol.
The mouthpiece 4 has an internal bore 7 and an outer cylindrical body 8 having an upper closed end 9 and a lower, flexible, end having an internally protruding wedge-shaped member 10 which may be formed of one or more tangs arranged to cooperate with an indent I I in an outer side wall of the reservoir I. A compression spring 12 is positioned between an upper end wall 13 of the reservoir and the closed end 9 of the mouthpiece 4.
The heating chamber has a heating coil 13 connected to an energy source, such as a battery (not shown).
The heating element 14 may comprise a single heating element or a plurality arranged suitably to effectively heat and vaporize the liquid. The heating element may be made of an electrically resistive material such as doped ceramics, molybdenum disilicide carbon, graphite, metal, quartz or composite materials made of a ceramic material and a metallic mater al Alternatively, the heating element may be an infrared heating element, a photonic source or an inductive heating element. Further, an anti-oxidation coating such as Apticote 810 may be applied to the heating element surface to prevent harmful toxins forming.
The heating element may produce heat in the range 20°C -200°C, usually in the range 30°C -90°C, and, in a preferred embodiment, 60°C, but the temperature is drug-dependent. The vapor temperature during activation may be in the range 40° -60° C. A pair of seals such as rubber or synthetic 0-rings are positioned around the heating chamber 15, each seal on an opposing side of the heating coil 14.
A cavity is provided internally of the heating chamber 3 of a size that determines the metered dose of liquid to be vaporized. At a lower end (as shown in the Figures), that is at an inlet end of the cavity, is a first valve 30 which is normally closed, and a second valve 31 which is also normally closed is located at an upper, outlet end of the cavity 20. As shown in Figure 6, a small opening 21 is provided at the top of the cavity 20 (as viewed in the Figures) which accesses a channel 22 between the heating chamber 3 and mouthpiece 4. The channel 21 interconnects with a void 23 between the upper and lower seals 30, 31 and is confined between the outer walls of the heating chamber and mouthpiece assembly, and the internal wall of the reservoir cylinder. Thus, in the position indicated in Figures 1 and 6, air (denoted by cross-hachuring) is trapped between the seals 30, 31 and inside the channel 22 and cavity 20 up to closed valve 31.
To activate the apparatus, the assembly of the mouth piece 4 and heating chamber 3 are depressed causing the member 10 to move out of contact from the indent I l and the spring 12 to be compressed. Continued depression of the assembly causes the first valve 30 to contact the pointed upper end 6 of the member 5 so as to open the first valve 30, as shown in Figure 2, and the air between the assembly of heating chamber and mouthpiece and reservoir cylinder wall expands with a resultant pressure drop.
As shown in Figure 3, as the valve 30 is opened, the pressure drop due to the expansion of the sealed volume of air and with the valve 30 open, so the liquid is urged by the air pressure to enter nto the cavity 20 thereby determining the metered dose.
Release of downward pressure on the assembly of the mouthpiece 4 and heating chamber 3 causes the spring 4 to lift the assembly until it is, again, held captive by the member 10 and indent 11. As the first valve 30 is lifted away from the member 5 so it closes, thereby isolating the metered dose of liquid from the liquid in the reservoir 1, as shown in Figure 4.
Referring to Figure 5, with the cavity filled, so the heating coil is activated by motion of the heating chamber, or by a manual control, e.g. a button, or by a pressure transducer when a user sucks on the mouthpiece, to vaporize the liquid. A negative pressure caused by sucking on the mouthpiece 4 causes the second valve 31 to open and 10 vapor to be sucked out of the internal bore 7, as shown by the arrow headed line. The particle size of the vaporized liquid may be 2 -5 microns, or less than 3 microns for systematic absorption.
The volume capacity of the liquid reservoir may be in the range 1 -10m1.
The volume capacity of the cavity may be in the range 5 -500111, preferably 8 - 335111 for salbutamol depending upon the reservoir volume and number of doses to be administered.
The heating element is arranged to suit the formulations properties, drug, volume and particle size distribution.
The mouth piece 4 may be formed of plastics, polymer, metal or metal alloy and 20 the heating chamber 3 may be formed of metal, metal alloy or ceramic. The first valve 30 and second valve 31 may be formed of plastics, polymer or rubber. The liquid reservoir I may be formed of plastics, polymer, metal, metal alloy, polycarbonate or glass.
In this specification, an apparatus/method/product "comprising" certain features is intended to be interpreted as meaning that it includes those features, but that it does not exclude the presence of other features.
Many variations are possible without departing from the scope of the present invention as defined in the appended claims.

Claims (16)

  1. CLAIMS1. A liquid metering dispensing apparatus for dispensing a metered liquid including a heating chamber having an internal cavity determining a metered dose of said liquid, an electrical heating coil arranged to heat said chamber, a normally closed first valve at an inlet of said cavity and a normally closed second valve at an outlet of said cavity, a reservoir for said liquid having an opening means for said first valve, said heating chamber being reciprocally mounted with respect to said reservoir, whereby, in operation, motion in a first direction of said heating chamber with respect to said reservoir brings said first valve into contact with said opening means to open said first valve, owing to a differential pressure drop liquid is caused to flow into said cavity, motion in a second direction causes said first valve to close, said heating coil is activated to vaporize liquid in said cavity, and provision of a negative pressure on said cavity causes said second valve to open so that vapor is sucked out of said cavity.
  2. 2. An apparatus as claimed in claim 1, wherein said heating chamber includes a mouth piece having an internal bore accessible by operation of said second valve to communicate with said cavity.
  3. 3. An apparatus as claimed in claim 1 or 2, wherein a pair of seals are provided around the heating chamber, each on an opposed side of the heating coil.
  4. 4. An apparatus ass claimed in any preceding claim, wherein the heating coil and the reservoir each have a circular cross-section and the heating coil is formed with a portion about the reservoir.
  5. 5. An apparatus as claimed in claim 2, wherein the mouth piece has a portion concentrically formed within said heating chamber and said heating chamber has a cylindrical outer body closed at one end, and spring bias means is interposed between said one end of said reservoir to bias said heating chamber in said second direction.
  6. 6. An apparatus as claimed in any preceding claim, wherein cooperating releasable captive means are provided between the heating chamber and the reservoir, against which the spring bias means exerts pressure.
  7. 7. An apparatus as claimed in any preceding claim, wherein the opening means is a member located in said reservoir arranged to contact and open said first valve when the heating chamber is depressed into said reservoir against the force of said spring bias means.
  8. An apparatus as claimed in claim 5, wherein the spring bias means is a compression spring.
  9. An apparatus as claimed in any preceding claim, wherein the heating coil includes an energy source arranged to heat an electrical element.
  10. 10. An apparatus as claimed in claim 9, wherein said electrical element is made of an electrically resistive material such as doped ceramics, molybdenum disilicide carbon, graphite, metal, quartz or composite materials made of a ceramic material and a metallic material.
  11. 11. An apparatus as claimed in claim 9, wherein the heating element is an infrared heating element, a photonic source or an inductive heating element.
  12. 12. An apparatus as claimed in any preceding claim, wherein the heating coil is arranged to convert the metered dose into droplets of 2 -5m crons, or less than 2 microns for systematic absorption.
  13. 13. An apparatus as claimed in any preceding claim, wherein the heating coil has a temperature in the range 20°C -200°C, usually in the range 30°C -90°C, and, preferably, 60°C.
  14. 14. An apparatus as claimed in any preceding claim, wherein the liquid is a medicament, or nicotine, plus an excipient including propylene glycol, vegetable glycerine, or an organic solvent such as ethanol.
  15. 15. An apparatus as claimed in any preceding claim, wherein the heating coil is activated by motion of the heating chamber, or by a manual control, e.g. a button, or by a pressure transducer when a user sucks on the mouthpiece, to vaporize the liquid.
  16. 16. A method of operating the apparatus as claimed in any preceding claim, wherein the reservoir contains liquid and including the steps of moving the heating chamber nto contact with the opening means to open the first valve, a differential pressure drop causing the liquid to flow into the cavity, moving the heating chamber in the opposite, second direction causing the first valve to close, activating the heating coil to vaporize liquid in the cavity, and providing a negative pressure on the cavity by sucking, causing the second valve to open so that vapor is sucked out of the cavity.
GB2310987.9A 2023-07-18 2023-07-18 Liquid metering dispensing apparatus and method of operating thereof Pending GB2632396A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB2310987.9A GB2632396A (en) 2023-07-18 2023-07-18 Liquid metering dispensing apparatus and method of operating thereof
PCT/GB2024/051787 WO2025017280A1 (en) 2023-07-18 2024-07-09 Liquid metering dispensing apparatus and method of operating thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2310987.9A GB2632396A (en) 2023-07-18 2023-07-18 Liquid metering dispensing apparatus and method of operating thereof

Publications (2)

Publication Number Publication Date
GB202310987D0 GB202310987D0 (en) 2023-08-30
GB2632396A true GB2632396A (en) 2025-02-12

Family

ID=87758521

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2310987.9A Pending GB2632396A (en) 2023-07-18 2023-07-18 Liquid metering dispensing apparatus and method of operating thereof

Country Status (2)

Country Link
GB (1) GB2632396A (en)
WO (1) WO2025017280A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017167509A1 (en) * 2016-03-31 2017-10-05 Philip Morris Products S.A. Aerosol-generating system with pump
US20220322491A1 (en) * 2015-12-22 2022-10-06 Altria Client Services Llc Cartridge for pump-operated aerosol-generating system
WO2023037214A1 (en) * 2021-09-09 2023-03-16 Philip Morris Products S.A. Aerosol-forming cartridge and system with nicotine gel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854877B1 (en) 2003-05-15 2007-04-20 Valois Sas FLUID PRODUCT DISPENSING VALVE.
US7222755B2 (en) 2004-11-19 2007-05-29 Glynntech, Inc. Metered dose squeeze dispenser with flexible-T dip tube
US11085550B2 (en) * 2014-02-28 2021-08-10 Ayr Ltd. Electronic vaporiser system
WO2016118645A1 (en) * 2015-01-22 2016-07-28 Fontem Holdings 1 B.V. Electronic vaporization devices
US20210308047A1 (en) * 2020-04-03 2021-10-07 Softhale Nv Methods of treatment using niclosamide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220322491A1 (en) * 2015-12-22 2022-10-06 Altria Client Services Llc Cartridge for pump-operated aerosol-generating system
WO2017167509A1 (en) * 2016-03-31 2017-10-05 Philip Morris Products S.A. Aerosol-generating system with pump
WO2023037214A1 (en) * 2021-09-09 2023-03-16 Philip Morris Products S.A. Aerosol-forming cartridge and system with nicotine gel

Also Published As

Publication number Publication date
WO2025017280A1 (en) 2025-01-23
GB202310987D0 (en) 2023-08-30

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