GB2604692B - Method for preparing recombinant subunit vaccine against novel coronavirus - Google Patents
Method for preparing recombinant subunit vaccine against novel coronavirus Download PDFInfo
- Publication number
- GB2604692B GB2604692B GB2115860.5A GB202115860A GB2604692B GB 2604692 B GB2604692 B GB 2604692B GB 202115860 A GB202115860 A GB 202115860A GB 2604692 B GB2604692 B GB 2604692B
- Authority
- GB
- United Kingdom
- Prior art keywords
- vaccine against
- subunit vaccine
- novel coronavirus
- preparing recombinant
- recombinant subunit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 241000711573 Coronaviridae Species 0.000 title 1
- 229940031626 subunit vaccine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/165—Coronaviridae, e.g. avian infectious bronchitis virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/20011—Coronaviridae
- C12N2770/20051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011216187.0A CN112089831B (en) | 2020-11-04 | 2020-11-04 | Preparation method of recombinant novel coronavirus subunit vaccine |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2604692A GB2604692A (en) | 2022-09-14 |
GB2604692B true GB2604692B (en) | 2023-12-06 |
Family
ID=73784551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2115860.5A Active GB2604692B (en) | 2020-11-04 | 2021-11-04 | Method for preparing recombinant subunit vaccine against novel coronavirus |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN112089831B (en) |
GB (1) | GB2604692B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113150171B (en) * | 2021-04-25 | 2023-05-16 | 中国农业科学院兰州兽医研究所 | African swine fever virus recombinant protein containing intramolecular adjuvant, expression vector and application |
CA3219206A1 (en) * | 2021-05-06 | 2022-11-10 | Hipra Scientific, S.L.U. | Sars-cov-2 subunit vaccine |
CA3219201A1 (en) * | 2021-05-06 | 2022-11-10 | Hipra Scientific, S.L.U. | Sars-cov-2 subunit vaccine |
CN113801209B (en) * | 2021-11-16 | 2022-02-11 | 浙江普康生物技术股份有限公司 | A novel coronavirus recombinant protein with broad-spectrum neutralizing activity and preparation method thereof |
CN114395015B (en) * | 2021-12-17 | 2022-09-23 | 烟台派诺生物技术有限公司 | Recombinant granular protein product suitable for industrial production and preparation method thereof |
CN115073564A (en) * | 2022-04-12 | 2022-09-20 | 北京尚位生物技术发展有限公司 | Novel genetic engineering recombinant protein, recombinant vector, recombinant engineering bacterium and vaccine of coronavirus |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106146658A (en) * | 2016-07-25 | 2016-11-23 | 黑龙江八农垦大学 | A kind of preparation method of Recombinant Swine epidemic diarrhea virus antibody |
CN106619543A (en) * | 2016-12-15 | 2017-05-10 | 首都医科大学 | Anti-tumor sea squirt polypeptide CS5931 freeze-dried powder needle preparation and preparation method thereof |
WO2019008599A1 (en) * | 2017-07-03 | 2019-01-10 | Bharat Biotech International Limited | A synthetic polypeptide epitope based vaccine composition |
EP3818989A1 (en) * | 2020-03-12 | 2021-05-12 | Universität Greifswald | Peptides and oligonucleotides for a sars-cov-2 vaccine |
WO2021198999A1 (en) * | 2020-04-03 | 2021-10-07 | Axon Neuroscience Se | Epitope-based vaccines for treatment of coronavirus associated diseases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102153652A (en) * | 2010-12-10 | 2011-08-17 | 浙江大学 | Expression method and application of fusion protein |
CN102633875A (en) * | 2012-04-27 | 2012-08-15 | 天津生机集团股份有限公司 | Renaturation liquid for recombining chicken alpha interferon inclusion body as well as preparation method and application thereof |
CN111560074B (en) * | 2020-03-20 | 2021-07-09 | 中山大学 | A novel coronavirus S protein single-domain subunit nanovaccine based on Helicobacter pylori ferritin |
-
2020
- 2020-11-04 CN CN202011216187.0A patent/CN112089831B/en active Active
-
2021
- 2021-11-04 GB GB2115860.5A patent/GB2604692B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106146658A (en) * | 2016-07-25 | 2016-11-23 | 黑龙江八农垦大学 | A kind of preparation method of Recombinant Swine epidemic diarrhea virus antibody |
CN106619543A (en) * | 2016-12-15 | 2017-05-10 | 首都医科大学 | Anti-tumor sea squirt polypeptide CS5931 freeze-dried powder needle preparation and preparation method thereof |
WO2019008599A1 (en) * | 2017-07-03 | 2019-01-10 | Bharat Biotech International Limited | A synthetic polypeptide epitope based vaccine composition |
EP3818989A1 (en) * | 2020-03-12 | 2021-05-12 | Universität Greifswald | Peptides and oligonucleotides for a sars-cov-2 vaccine |
WO2021198999A1 (en) * | 2020-04-03 | 2021-10-07 | Axon Neuroscience Se | Epitope-based vaccines for treatment of coronavirus associated diseases |
Non-Patent Citations (1)
Title |
---|
Vaccine, vol. 39, 2021, Qiu-Dong et al, " Recombinant SRS-CoV-2 RBD with a built in T helper epitope..." pages 1241-1247 * |
Also Published As
Publication number | Publication date |
---|---|
GB2604692A (en) | 2022-09-14 |
CN112089831A (en) | 2020-12-18 |
CN112089831B (en) | 2021-04-02 |
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