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GB2530700A - Biosensor - Google Patents

Biosensor Download PDF

Info

Publication number
GB2530700A
GB2530700A GB1601669.3A GB201601669A GB2530700A GB 2530700 A GB2530700 A GB 2530700A GB 201601669 A GB201601669 A GB 201601669A GB 2530700 A GB2530700 A GB 2530700A
Authority
GB
United Kingdom
Prior art keywords
flow path
molecules
functionalised
sensor
path
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1601669.3A
Other versions
GB201601669D0 (en
Inventor
Owen Guy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Swansea University
Original Assignee
Swansea University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Swansea University filed Critical Swansea University
Publication of GB201601669D0 publication Critical patent/GB201601669D0/en
Publication of GB2530700A publication Critical patent/GB2530700A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Endocrinology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

A sensor (1) is formed of a graphene or silicon based nanostructure (10) having a flow path (21) which may be a channel or nanowire. The flow path is functionalised to attract certain molecules. The flow path has contacts (22) at either and the loading of the functionalised flow path alters the charge on that path and gives a measurement of the molecules. The sensor can provide a particularly sensitive device which can monitor a number of biomolecules in real-time, and in particular molecules associated with stress.
GB1601669.3A 2013-07-01 2014-06-27 Biosensor Withdrawn GB2530700A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1311760.1A GB201311760D0 (en) 2013-07-01 2013-07-01 Biosensor
PCT/GB2014/000260 WO2015001286A1 (en) 2013-07-01 2014-06-27 Biosensor

Publications (2)

Publication Number Publication Date
GB201601669D0 GB201601669D0 (en) 2016-03-16
GB2530700A true GB2530700A (en) 2016-03-30

Family

ID=48999319

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB1311760.1A Ceased GB201311760D0 (en) 2013-07-01 2013-07-01 Biosensor
GB1601669.3A Withdrawn GB2530700A (en) 2013-07-01 2014-06-27 Biosensor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB1311760.1A Ceased GB201311760D0 (en) 2013-07-01 2013-07-01 Biosensor

Country Status (2)

Country Link
GB (2) GB201311760D0 (en)
WO (1) WO2015001286A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3131121B1 (en) * 2015-08-12 2018-05-09 Provenance Asset Group LLC Method for making a graphene-based field-effect apparatus
KR101706732B1 (en) 2015-12-30 2017-02-27 주식회사 엔디디 Bio-sensing device
CN107177584B (en) * 2017-06-18 2020-06-09 天津大学 Preparation method of integrated immobilized enzyme for penicillin synthesis
CN108828032B (en) * 2018-09-18 2024-04-19 天津博硕科技有限公司 Online electrochemical detection device, method and electrochemical immunoassay instrument
RU2697701C1 (en) * 2018-12-28 2019-08-19 федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный технический университет имени Н.Э. Баумана (национальный исследовательский университет)" (МГТУ им. Н.Э. Баумана) Method of producing a biological sensor based on graphene oxide and a biological sensor on a flexible substrate
CN113413933A (en) * 2021-07-02 2021-09-21 山东大学第二医院 Micro-fluidic chip based on glass microspheres and application thereof
CN115501007B (en) * 2022-11-04 2023-03-17 清华大学 Design and processing method of polymer bone implant multi-channel sensor
CN115561295B (en) * 2022-12-06 2023-06-06 有研(广东)新材料技术研究院 A silicon nanowire field-effect glucose sensor and its preparation method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010059687A2 (en) * 2008-11-18 2010-05-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A semiconductor for measuring biological interactions
WO2011004136A1 (en) * 2009-07-07 2011-01-13 Uws Ventures Limited Graphene biosensor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010059687A2 (en) * 2008-11-18 2010-05-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A semiconductor for measuring biological interactions
WO2011004136A1 (en) * 2009-07-07 2011-01-13 Uws Ventures Limited Graphene biosensor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JIAO LUYANG ET AL *
OWEN J GUY ET AL *
OWEN J GUY ET AL GRAPHNENE *
TEIXEIRA SOFIA ET AL *
YAN MAO ET AL ELECTRCHEMICAL *

Also Published As

Publication number Publication date
WO2015001286A1 (en) 2015-01-08
GB201601669D0 (en) 2016-03-16
GB201311760D0 (en) 2013-08-14

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)