[go: up one dir, main page]

GB2372502B - Carbohydrate compounds containing cholesterol and their use - Google Patents

Carbohydrate compounds containing cholesterol and their use

Info

Publication number
GB2372502B
GB2372502B GB0113781A GB0113781A GB2372502B GB 2372502 B GB2372502 B GB 2372502B GB 0113781 A GB0113781 A GB 0113781A GB 0113781 A GB0113781 A GB 0113781A GB 2372502 B GB2372502 B GB 2372502B
Authority
GB
United Kingdom
Prior art keywords
compounds containing
containing cholesterol
carbohydrate compounds
carbohydrate
cholesterol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB0113781A
Other versions
GB2372502A (en
GB0113781D0 (en
Inventor
Michael Jorgensen
Michael Keller
Andrew David Miller
Eric Perouzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial College of London
Ip2ipo Innovations Ltd
Mitsubishi Chemical Corp
Original Assignee
Imperial College Innovations Ltd
Imperial College of London
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2000/004767 external-priority patent/WO2001048233A1/en
Application filed by Imperial College Innovations Ltd, Imperial College of London, Mitsubishi Chemical Corp filed Critical Imperial College Innovations Ltd
Publication of GB0113781D0 publication Critical patent/GB0113781D0/en
Priority to US10/008,129 priority Critical patent/US20020188023A1/en
Priority to CA002431896A priority patent/CA2431896A1/en
Priority to AT01270543T priority patent/ATE318834T1/en
Priority to DK01270543T priority patent/DK1351972T3/en
Priority to PCT/GB2001/005385 priority patent/WO2002048170A1/en
Priority to JP2002550095A priority patent/JP2004522722A/en
Priority to CNB018225276A priority patent/CN100482676C/en
Priority to JP2002549701A priority patent/JP2004520301A/en
Priority to RU2003120456/15A priority patent/RU2003120456A/en
Priority to CNA018226000A priority patent/CN1524125A/en
Priority to CZ20031636A priority patent/CZ20031636A3/en
Priority to EP06075338A priority patent/EP1669366A1/en
Priority to EP01270614A priority patent/EP1377673A2/en
Priority to CZ20031637A priority patent/CZ298560B6/en
Priority to AU2212802A priority patent/AU2212802A/en
Priority to PCT/GB2001/005383 priority patent/WO2002048380A2/en
Priority to EP01270543A priority patent/EP1351972B1/en
Priority to RU2003120455/04A priority patent/RU2290409C2/en
Priority to ES01270543T priority patent/ES2259007T3/en
Priority to CA002364392A priority patent/CA2364392A1/en
Priority to AU2002222128A priority patent/AU2002222128B2/en
Priority to US10/450,356 priority patent/US20040081687A1/en
Priority to AU2002220894A priority patent/AU2002220894A1/en
Priority to DE60117465T priority patent/DE60117465T2/en
Priority to CA002364730A priority patent/CA2364730A1/en
Publication of GB2372502A publication Critical patent/GB2372502A/en
Priority to HK03109313A priority patent/HK1057048A1/en
Publication of GB2372502B publication Critical patent/GB2372502B/en
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/15Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
GB0113781A 2000-12-12 2001-06-06 Carbohydrate compounds containing cholesterol and their use Expired - Fee Related GB2372502B (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
US10/008,129 US20020188023A1 (en) 2000-12-12 2001-11-05 Compound
DE60117465T DE60117465T2 (en) 2000-12-12 2001-12-05 LIPIDE WITH AMINOXY GROUP
CZ20031637A CZ298560B6 (en) 2000-12-12 2001-12-05 Process for preparing modified lipids
EP01270543A EP1351972B1 (en) 2000-12-12 2001-12-05 Lipids comprising an aminoxy group
DK01270543T DK1351972T3 (en) 2000-12-12 2001-12-05 Lipids comprising an amine oxy group
PCT/GB2001/005385 WO2002048170A1 (en) 2000-12-12 2001-12-05 Lipids comprising an aminoxy group
JP2002550095A JP2004522722A (en) 2000-12-12 2001-12-05 Compound
CNB018225276A CN100482676C (en) 2000-12-12 2001-12-05 N-oxy-group-contained lipids
JP2002549701A JP2004520301A (en) 2000-12-12 2001-12-05 Lipids containing aminoxy groups
RU2003120456/15A RU2003120456A (en) 2000-12-12 2001-12-05 COMPOUND
CNA018226000A CN1524125A (en) 2000-12-12 2001-12-05 Compound
CZ20031636A CZ20031636A3 (en) 2000-12-12 2001-12-05 Compound capable to act as a cationic lipid
EP06075338A EP1669366A1 (en) 2000-12-12 2001-12-05 Lipids comprising an aminoxy group
EP01270614A EP1377673A2 (en) 2000-12-12 2001-12-05 Glycosilated cationic lipids for liposomes used in drug delivery
CA002431896A CA2431896A1 (en) 2000-12-12 2001-12-05 Compound
AU2212802A AU2212802A (en) 2000-12-12 2001-12-05 Lipids comprising an aminoxy group
PCT/GB2001/005383 WO2002048380A2 (en) 2000-12-12 2001-12-05 Glycosilated cationic lipids for liposomes used in drug delivery
AT01270543T ATE318834T1 (en) 2000-12-12 2001-12-05 LIPIDS WITH AMINOOXY GROUP
RU2003120455/04A RU2290409C2 (en) 2000-12-12 2001-12-05 Method for preparing compounds, composition for preparing medicinal agent
ES01270543T ES2259007T3 (en) 2000-12-12 2001-12-05 LIPIDS THAT INCLUDE AN AMINOXI GROUP.
CA002364392A CA2364392A1 (en) 2000-12-12 2001-12-05 Compound
AU2002222128A AU2002222128B2 (en) 2000-12-12 2001-12-05 Lipids comprising an aminoxy group
US10/450,356 US20040081687A1 (en) 2000-12-12 2001-12-05 Compound
AU2002220894A AU2002220894A1 (en) 2000-12-12 2001-12-05 Compound
CA002364730A CA2364730A1 (en) 2000-12-12 2001-12-06 Lipids comprising an aminoxy group
HK03109313A HK1057048A1 (en) 2000-12-12 2003-12-22 Lipids comprising an aminoxy group

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2000/004767 WO2001048233A1 (en) 1999-12-23 2000-12-12 Viral core protein-cationic lipid-nucleic acid-delivery complexes

Publications (3)

Publication Number Publication Date
GB0113781D0 GB0113781D0 (en) 2001-07-25
GB2372502A GB2372502A (en) 2002-08-28
GB2372502B true GB2372502B (en) 2004-10-13

Family

ID=9886610

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0113781A Expired - Fee Related GB2372502B (en) 2000-12-12 2001-06-06 Carbohydrate compounds containing cholesterol and their use

Country Status (1)

Country Link
GB (1) GB2372502B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1735626A2 (en) * 2004-04-16 2006-12-27 EVOTEC Neurosciences GmbH Diagnostic and therapeutic use of kcnc1 for neurodegenerative diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004545A1 (en) * 1992-08-11 1994-03-03 Rijksuniversiteit Leiden Triantennary cluster glycosides, their preparation and use
WO1997039019A1 (en) * 1996-04-12 1997-10-23 University Of Pittsburgh Novel cationic cholesteryl derivatives containing cyclic polar groups

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004545A1 (en) * 1992-08-11 1994-03-03 Rijksuniversiteit Leiden Triantennary cluster glycosides, their preparation and use
WO1997039019A1 (en) * 1996-04-12 1997-10-23 University Of Pittsburgh Novel cationic cholesteryl derivatives containing cyclic polar groups

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WPI Abstract Acc. No. 1994-347142 and JP620071597A *

Also Published As

Publication number Publication date
GB2372502A (en) 2002-08-28
GB0113781D0 (en) 2001-07-25

Similar Documents

Publication Publication Date Title
EG23122A (en) Pyrrolcarboxamides and pyrrolcarbothioamides
AU9667901A (en) Mycoattractants and mycopesticides
IL155071A0 (en) Glucopyranosyloxybenzylbenzene derivatives and medical compositions containing the same
TW483324U (en) Diaper
GB0016787D0 (en) Compounds useful in therapy
TW489642U (en) Underpants-type diaper
EP1313477A4 (en) Compounds and methods
GB0009591D0 (en) Medical combinations
TW477220U (en) Underpants-type diaper
EP1274424A4 (en) Compounds and methods
AU9352801A (en) Diaper
HUP0103845A3 (en) Disinfecting composition and its use
AU5073101A (en) Lipid composition and use thereof
EP1316586A4 (en) Diphenylsquarylium compound and display filter containing the same
GB9802599D0 (en) Medical use
EP1308571A4 (en) Form panel and panel holding member
HK1040374B (en) Swab
GB0021497D0 (en) Compounds and their use
GB0007530D0 (en) Trityl-type compounds and their use
GB0028879D0 (en) Adsorbents and their use
GB0030541D0 (en) Medical uses
GB0020449D0 (en) Crystal structure
GB2372502B (en) Carbohydrate compounds containing cholesterol and their use
EP1343796A4 (en) Compounds and methods
GB0022678D0 (en) Medi Disposasock

Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20090606