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GB2324527B - Small molecule inhibitors of rotamase enzyme activity - Google Patents

Small molecule inhibitors of rotamase enzyme activity

Info

Publication number
GB2324527B
GB2324527B GB9815112A GB9815112A GB2324527B GB 2324527 B GB2324527 B GB 2324527B GB 9815112 A GB9815112 A GB 9815112A GB 9815112 A GB9815112 A GB 9815112A GB 2324527 B GB2324527 B GB 2324527B
Authority
GB
United Kingdom
Prior art keywords
small molecule
enzyme activity
molecule inhibitors
rotamase enzyme
rotamase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9815112A
Other versions
GB2324527A (en
GB9815112D0 (en
GB2324527A8 (en
Inventor
Gregory S Hamilton
Joseph P Steiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Corp of North America
Original Assignee
Guilford Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/479,436 external-priority patent/US5614547A/en
Priority claimed from US08/650,461 external-priority patent/US5859031A/en
Application filed by Guilford Pharmaceuticals Inc filed Critical Guilford Pharmaceuticals Inc
Publication of GB9815112D0 publication Critical patent/GB9815112D0/en
Publication of GB2324527A publication Critical patent/GB2324527A/en
Application granted granted Critical
Publication of GB2324527B publication Critical patent/GB2324527B/en
Publication of GB2324527A8 publication Critical patent/GB2324527A8/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB9815112A 1995-06-07 1996-06-05 Small molecule inhibitors of rotamase enzyme activity Expired - Fee Related GB2324527B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/479,436 US5614547A (en) 1995-06-07 1995-06-07 Small molecule inhibitors of rotamase enzyme
US08/650,461 US5859031A (en) 1995-06-07 1996-05-21 Small molecule inhibitors of rotamase enzyme activity
GB9624257A GB2305176B (en) 1995-06-07 1996-06-05 Small molecule inhibitors of rotamase enzyme activity

Publications (4)

Publication Number Publication Date
GB9815112D0 GB9815112D0 (en) 1998-09-09
GB2324527A GB2324527A (en) 1998-10-28
GB2324527B true GB2324527B (en) 1999-12-22
GB2324527A8 GB2324527A8 (en) 2000-10-09

Family

ID=27268598

Family Applications (3)

Application Number Title Priority Date Filing Date
GB9815112A Expired - Fee Related GB2324527B (en) 1995-06-07 1996-06-05 Small molecule inhibitors of rotamase enzyme activity
GB9905606A Withdrawn GB2332673A (en) 1995-06-07 1996-06-05 Small molecule inhibitors of rotamase enzyme activity
GB9817938A Withdrawn GB2325230A (en) 1995-06-07 1996-06-05 Intermediate for Neurotrophic N-glyoxylprolyl esters

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB9905606A Withdrawn GB2332673A (en) 1995-06-07 1996-06-05 Small molecule inhibitors of rotamase enzyme activity
GB9817938A Withdrawn GB2325230A (en) 1995-06-07 1996-06-05 Intermediate for Neurotrophic N-glyoxylprolyl esters

Country Status (1)

Country Link
GB (3) GB2324527B (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000278A1 (en) * 1990-07-02 1992-01-09 Vertex Pharmaceuticals Incorporated Novel immunosuppressive compounds
WO1992019593A1 (en) * 1991-05-09 1992-11-12 Vertex Pharmaceuticals Incorporated Novel immunosuppressive compounds
WO1992021313A2 (en) * 1991-05-24 1992-12-10 Vertex Pharmaceuticals Incorporated Novel immunosuppressive compounds
GB2305605A (en) * 1995-06-07 1997-04-16 Guilford Pharm Inc Inhibitors of rotamase enzyme activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75019B (en) * 1980-09-17 1984-07-12 Univ Miami

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000278A1 (en) * 1990-07-02 1992-01-09 Vertex Pharmaceuticals Incorporated Novel immunosuppressive compounds
US5330993A (en) * 1990-07-02 1994-07-19 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
WO1992019593A1 (en) * 1991-05-09 1992-11-12 Vertex Pharmaceuticals Incorporated Novel immunosuppressive compounds
WO1992021313A2 (en) * 1991-05-24 1992-12-10 Vertex Pharmaceuticals Incorporated Novel immunosuppressive compounds
GB2305605A (en) * 1995-06-07 1997-04-16 Guilford Pharm Inc Inhibitors of rotamase enzyme activity

Also Published As

Publication number Publication date
GB2325230A (en) 1998-11-18
GB2332673A (en) 1999-06-30
GB2324527A (en) 1998-10-28
GB9815112D0 (en) 1998-09-09
GB2324527A8 (en) 2000-10-09
GB9905606D0 (en) 1999-05-05
GB9817938D0 (en) 1998-10-14

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Legal Events

Date Code Title Description
711B Application made for correction of error (sect. 117/77)
711G Correction allowed (sect. 117/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20080605