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GB2322570A - Apparatus for multi-well microscale synthesis - Google Patents

Apparatus for multi-well microscale synthesis

Info

Publication number
GB2322570A
GB2322570A GB9812156A GB9812156A GB2322570A GB 2322570 A GB2322570 A GB 2322570A GB 9812156 A GB9812156 A GB 9812156A GB 9812156 A GB9812156 A GB 9812156A GB 2322570 A GB2322570 A GB 2322570A
Authority
GB
United Kingdom
Prior art keywords
synthesis
block
wells
well
upper cover
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9812156A
Other versions
GB9812156D0 (en
GB2322570B (en
Inventor
Paul B Robbins
James E Stanchfield
Chris Bailey
David J Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robbins Scientific LLC
Original Assignee
Robbins Scientific LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robbins Scientific LLC filed Critical Robbins Scientific LLC
Publication of GB9812156D0 publication Critical patent/GB9812156D0/en
Publication of GB2322570A publication Critical patent/GB2322570A/en
Application granted granted Critical
Publication of GB2322570B publication Critical patent/GB2322570B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00319—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks the blocks being mounted in stacked arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00331—Details of the reactor vessels
    • B01J2219/00333—Closures attached to the reactor vessels
    • B01J2219/00335—Septa
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00414—Means for dispensing and evacuation of reagents using suction
    • B01J2219/00416—Vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A multi-well synthesis and filtration apparatus (10) for performing multiple, simultaneous chemical reactions, workups and purifications on a micro scale. The apparatus (10) includes a deep-well synthesis block (12) having a plurality of wells (24) fitted with filter disks (48), an upper cover (14), a lower cover (16) and a pair of sheet gaskets (18 and 20). The sheet gaskets (18 and 20) are interposed between the upper and lower covers (14 and 16) to seal inlet portions (38) and outlet spouts (40) of the wells (24). Apertures (70) in the upper cover (14) provide that the sheet gasket (18) may be punctured for introduction of materials and/or maintenance of an inert atmosphere. The design is such that either the synthesis block (12) alone, or the block (12) as covered, is dimensionally of a size that provides for a footprint that is the same as a standard microplate.
GB9812156A 1996-11-18 1997-11-18 Apparatus for multi-well microscale synthesis Expired - Fee Related GB2322570B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3102496P 1996-11-18 1996-11-18
US4321197P 1997-04-09 1997-04-09
PCT/US1997/021228 WO1998022219A1 (en) 1996-11-18 1997-11-18 Apparatus for multi-well microscale synthesis

Publications (3)

Publication Number Publication Date
GB9812156D0 GB9812156D0 (en) 1998-08-05
GB2322570A true GB2322570A (en) 1998-09-02
GB2322570B GB2322570B (en) 2000-11-15

Family

ID=26706731

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9812156A Expired - Fee Related GB2322570B (en) 1996-11-18 1997-11-18 Apparatus for multi-well microscale synthesis

Country Status (5)

Country Link
EP (1) EP0948409A4 (en)
JP (1) JP3338961B2 (en)
AU (1) AU5359398A (en)
GB (1) GB2322570B (en)
WO (1) WO1998022219A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1156879A1 (en) * 1999-02-05 2001-11-28 Robbins Scientific Corporation Multi-well array with adjustable plenum
JP2002536653A (en) * 1999-02-11 2002-10-29 アベンティス・クロップサイエンス・エス・アー Combination library synthesis, characterization, assay method and apparatus
US6500609B1 (en) 1999-02-11 2002-12-31 Scynexis Chemistry & Automation, Inc. Method and apparatus for synthesizing characterizing and assaying combinatorial libraries
DE10025698A1 (en) 2000-05-23 2001-11-29 Merck Patent Gmbh Parallel microsynthesis device
EP1872855A1 (en) * 2006-06-27 2008-01-02 F.Hoffmann-La Roche Ag Plate for equilibrating a fluid
KR101409325B1 (en) * 2013-11-08 2014-06-18 배재대학교 산학협력단 Apparatus for multiple reaction and purification of chemical
EP3289856A1 (en) * 2016-09-05 2018-03-07 Deutsche Saatveredelung AG Sowing and sampling device for plants

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4092481A (en) * 1974-06-10 1978-05-30 Dynamit Nobel Aktiengesellschaft Process for the recovery of dimethyl terephthalate and of intermediates from the dimethyl terephthalate manufacture
US4304865A (en) * 1978-08-31 1981-12-08 National Research Development Corporation Harvesting material from micro-culture plates
US4493815A (en) * 1983-07-28 1985-01-15 Bio-Rad Laboratories, Inc. Supporting and filtering biochemical test plate assembly
US4526690A (en) * 1983-02-04 1985-07-02 Millipore Corporation Apparatus for nucleic acid quantification
US4787988A (en) * 1987-02-20 1988-11-29 Biomedical Research And Development Laboratories, Inc. Cell harvester
US4948564A (en) * 1986-10-28 1990-08-14 Costar Corporation Multi-well filter strip and composite assemblies
US5039493A (en) * 1990-05-04 1991-08-13 The United States Of America As Represented By The Secretary Of The Navy Positive pressure blotting apparatus with hydropholic filter means
US5082631A (en) * 1990-06-07 1992-01-21 Transpan Company Transport tray with pivotal circular cam ramp for biological samples
US5108704A (en) * 1988-09-16 1992-04-28 W. R. Grace & Co.-Conn. Microfiltration apparatus with radially spaced nozzles
US5219528A (en) * 1989-07-28 1993-06-15 Pierce Chemical Company Apparatus for rapid immunoassays
US5260028A (en) * 1988-02-22 1993-11-09 Astle Thomas W Method and apparatus for effecting solid phase extraction
US5266272A (en) * 1991-10-31 1993-11-30 Baxter Diagnostics Inc. Specimen processing and analyzing systems with a station for holding specimen trays during processing
US5283039A (en) * 1991-09-18 1994-02-01 Minnesota Mining And Manufacturing Company Multi-well filtration apparatus
US5324483A (en) * 1992-10-08 1994-06-28 Warner-Lambert Company Apparatus for multiple simultaneous synthesis
US5384093A (en) * 1992-04-03 1995-01-24 Toa Medical Electronics Co., Ltd. Apparatus for aspirating and discharging a liquid sample
US5417922A (en) * 1993-05-14 1995-05-23 Board Of Regents - University Of Nebraska Specimen carrier
US5609826A (en) * 1995-04-17 1997-03-11 Ontogen Corporation Methods and apparatus for the generation of chemical libraries

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902481A (en) * 1987-12-11 1990-02-20 Millipore Corporation Multi-well filtration test apparatus
DK492788D0 (en) * 1988-09-02 1988-09-05 Morten Meldal Peptide Synthesizer
US5380662A (en) * 1990-06-01 1995-01-10 Robbins Scientific Corporation Hybridization incubator with rotisserie mechanism

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4092481A (en) * 1974-06-10 1978-05-30 Dynamit Nobel Aktiengesellschaft Process for the recovery of dimethyl terephthalate and of intermediates from the dimethyl terephthalate manufacture
US4304865A (en) * 1978-08-31 1981-12-08 National Research Development Corporation Harvesting material from micro-culture plates
US4526690A (en) * 1983-02-04 1985-07-02 Millipore Corporation Apparatus for nucleic acid quantification
US4493815A (en) * 1983-07-28 1985-01-15 Bio-Rad Laboratories, Inc. Supporting and filtering biochemical test plate assembly
US4948564A (en) * 1986-10-28 1990-08-14 Costar Corporation Multi-well filter strip and composite assemblies
US4787988A (en) * 1987-02-20 1988-11-29 Biomedical Research And Development Laboratories, Inc. Cell harvester
US5260028A (en) * 1988-02-22 1993-11-09 Astle Thomas W Method and apparatus for effecting solid phase extraction
US5108704A (en) * 1988-09-16 1992-04-28 W. R. Grace & Co.-Conn. Microfiltration apparatus with radially spaced nozzles
US5219528A (en) * 1989-07-28 1993-06-15 Pierce Chemical Company Apparatus for rapid immunoassays
US5039493A (en) * 1990-05-04 1991-08-13 The United States Of America As Represented By The Secretary Of The Navy Positive pressure blotting apparatus with hydropholic filter means
US5082631A (en) * 1990-06-07 1992-01-21 Transpan Company Transport tray with pivotal circular cam ramp for biological samples
US5283039A (en) * 1991-09-18 1994-02-01 Minnesota Mining And Manufacturing Company Multi-well filtration apparatus
US5266272A (en) * 1991-10-31 1993-11-30 Baxter Diagnostics Inc. Specimen processing and analyzing systems with a station for holding specimen trays during processing
US5384093A (en) * 1992-04-03 1995-01-24 Toa Medical Electronics Co., Ltd. Apparatus for aspirating and discharging a liquid sample
US5324483A (en) * 1992-10-08 1994-06-28 Warner-Lambert Company Apparatus for multiple simultaneous synthesis
US5324483B1 (en) * 1992-10-08 1996-09-24 Warner Lambert Co Apparatus for multiple simultaneous synthesis
US5417922A (en) * 1993-05-14 1995-05-23 Board Of Regents - University Of Nebraska Specimen carrier
US5609826A (en) * 1995-04-17 1997-03-11 Ontogen Corporation Methods and apparatus for the generation of chemical libraries

Also Published As

Publication number Publication date
AU5359398A (en) 1998-06-10
JP2000507502A (en) 2000-06-20
GB9812156D0 (en) 1998-08-05
EP0948409A4 (en) 2001-12-05
WO1998022219A1 (en) 1998-05-28
EP0948409A1 (en) 1999-10-13
JP3338961B2 (en) 2002-10-28
GB2322570B (en) 2000-11-15

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Legal Events

Date Code Title Description
727 Application made for amendment of specification (sect. 27/1977)
727A Application for amendment of specification now open to opposition (sect. 27/1977)
727B Case decided by the comptroller ** specification amended (sect. 27/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20031118