GB2310856A - Producing cellulose-based excipient - Google Patents
Producing cellulose-based excipient Download PDFInfo
- Publication number
- GB2310856A GB2310856A GB9604564A GB9604564A GB2310856A GB 2310856 A GB2310856 A GB 2310856A GB 9604564 A GB9604564 A GB 9604564A GB 9604564 A GB9604564 A GB 9604564A GB 2310856 A GB2310856 A GB 2310856A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cellulosic material
- grinder
- drive
- classifier
- coarse
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C25/00—Control arrangements specially adapted for crushing or disintegrating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/08—Cellulose derivatives
- C08L1/26—Cellulose ethers
- C08L1/28—Alkyl ethers
- C08L1/286—Alkyl ethers substituted with acid radicals, e.g. carboxymethyl cellulose [CMC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Description
"Production Method"
The invention relates to a method for producing cellulosebased excipients such as carboxymethylcellulose and the like.
Introduction
The specifications for cellulose based excipients, particularly pharmaceutical excipients, are high in order to comply with processing and regulatory requirements.
Such cellulose products generally have a high value, however, there is a need to optimise the processing method to lninimise losses and to provide a range of such cellulose-based products which meet these requirements.
Statements of Invention
According to the invention, there is provided a method for producing cellulose-based excipients comprising the steps of:
setting a desired operating load on a grinder;
delivering coarse cellulosic material from a feed
hopper to the grinder;
grinding the coarse cellulosic material;
classifying the ground cellulosic material in a
grinder having a classifier drive unit;
controlling the classifier drive unit in accordance
with the operating load on the grinder;
drawing the ground and classified cellulosic material
into a grinder receiving bin;
delivering the ground and classified cellulosic
material to a separator;
separating the classified cellulosic material into
cellulosic material of a desired size and oversize
material;
delivering the cellulosic material of desired size
into a holding bin; and
packing the cellulosic material from the holding bin.
In one embodiment of the invention, the ground and classified material is drawn into the grinder receiving bin by a fan having a variable speed drive and the method includes the step, prior to delivery of the coarse cellulosic material to the grinder, of setting the speed of the fan drive to a desired speed matched to the coarse cellulosic material.
Preferably, the method includes the step of delivering the oversize cellulosic material from the separator to the feed hopper for recycling.
In one embodiment of the invention, the operating load on the grinder drive is sensed by sensing the operating power of the grinder drive, the classifier drive unit is a variable speed drive and the classifier drive unit is controlled by varying the drive speed of the classifier in accordance with the operating power of the grinder drive.
In a preferred arrangement, a rotary air valve is provided at the feed hopper outlet and the coarse cellulosic material is delivered from the feed hopper to the grinder by a blower unit.
Preferably, the method includes the step of de-bagging coarse cellulosic materials into the feed hopper.
Detailed Description of the Invention
The invention will be more clearly understood from the following description thereof given by way of example only with reference to the accompanying drawing which is a schematic diagram illustrating the method for producing cellulose-based pharmaceutical excipients according to the invention.
Referring to the drawing, there is illustrated a method for producing cellulose-based excipients and in this case pharmaceutical excipients such as carboxymethylcellulose and the like. The method is in this case used in the production of three different types of cellulose-based excipients. These may be a blend of different excipients.
Equivalent equipment used in processing different cellulosic materials are illustrated in some cases for clarity as separate items but are assigned the same reference numerals.
In the method of the invention, coarse cellulosic material is delivered into a feed hopper 1 having an outlet fitted in this case with a fixed speed rotary valve 2. The coarse cellulosic material is blown by a blower unit 3 along a common supply line 4 to a grinder/classifier unit 5. The grinder/classifier unit 5 comprises a grinder 10 and a classifier 11. The grinder 10 has a drive unit with an associated power load, in this case, operating amps monitor 12 fitted with a controller 13. The classifier 11 is driven by a variable speed drive unit 15, the operation of which is controlled by the controller 13.
A fan 20 fitted with a variable speed drive unit 21 draws ground and classified cellulosic material along a delivery line 22 to a grinder receiving bin 23. Air is exhausted through a plurality of air filter socks 25. The receiving bin 23 has an outlet fitted with a rotary valve 27 through which the ground and classified cellulosic material is delivered to a separator screen unit 30. The screen unit 30 may have any size of aperture fitted to achieve separation into a desired size fraction and oversize. The desired size fraction is delivered through a rotary valve 31 by a blower unit 32 along an output line 35. The oversize material is recovered and delivered along a recycling line 38 to the feed hopper 1. In some cases, the cellulosic material with the desired size distribution is delivered into a silo 40 and collected in a holding bin 41 available for packaging on demand. In another case, the cellulosic material is blended for improved consistency in a blender unit 45 fitted with a blending screw prior to delivery to a silo 40.
In the method of the invention, cellulose-based excipients are produced by first setting, using the variable speed drive unit 21, an operating speed for the fan 20 matched to the cellulosic material being processed. A desired operating load on the grinder 10 is then set using the amp sensing unit 12 linked to the controller 13 for controlling the speed control unit 15 of the classifier 11. The fan 20 and blower unit 3 are operated to release the valve 2, allowing coarse cellulosic material to be delivered along the feed line 4 to the grinder 10. The coarse cellulosic material is ground in the grinder 10 and then classified in the classifier 11. The drive unit 15 of the classifier 11 is controlled in accordance with the operating load on the grinder 10. The fan 20 draws the ground and classified cellulosic material into the grinder receiving bin 23. On operation of the rotary valve 27, the cellulosic material is delivered to the separator unit 30 where the cellulosic material is separated into cellulosic material of a desired size and oversize material which is recycled to the feed hopper 1.
The invention provides an optimised process for producing not only one but several different cellulose-based excipients, particularly pharmaceutical excipients. The particle size range of the cellulosic material is consistent and a wider range, particularly fine grades, of particle sizes may be produced. As any oversize material is recycled, the yield is optimised. The throughput of cellulosic material is maximised as the residence time in the grinder/classifier unit is optimised. The invention also provides a method of production of cellulosic material in which the energy requirement is optimised.
The invention is not limited to the embodiments hereinbefore described which may be varied in detail.
Claims (8)
1. A method for producing cellulose-based excipients
comprising the steps of:
setting a desired operating load on a grinder;
delivering coarse cellulosic material from a
feed hopper to the grinder;
grinding the coarse cellulosic material;
classifying the ground cellulosic material in a
grinder having a classifier drive unit;
controlling the classifier drive unit in
accordance with the operating load on the
grinder;
drawing the ground and classified cellulosic
material into a grinder receiving bin;
delivering the ground and classified cellulosic
material to a separator;
separating the classified cellulosic material
into cellulosic material of a desired size and
oversize material;
delivering the cellulosic material of desired
size into a holding bin; and
packing the cellulosic material from the holding
bin.
2. A method as claimed in claim 1 wherein the ground and
classified material is drawn into the grinder
receiving bin by a fan having a variable speed drive
and the method includes the step, prior to delivery
of the coarse cellulosic material to the grinder, of
setting the speed of the fan drive to a desired speed
matched to the coarse cellulosic material.
3. A method as claimed in claim 1 or 2 including the
step of delivering the oversize cellulosic material
from the separator to the feed hopper for recycling.
4. A method as claimed in any preceding claim wherein
the operating load on the grinder drive is sensed by
sensing the operating power of the grinder drive, the
classifier drive unit is a variable speed drive and
the classifier drive unit is controlled by varying
the drive speed of the classifier in accordance with
the operating power of the grinder drive.
5. A method as claimed in any preceding claim wherein a
rotary air valve is provided at the feed hopper
outlet and the coarse cellulosic material is
delivered from the feed hopper to the grinder by a
blower unit.
6. A method as claimed in any preceding claim including
the step of de-bagging one or more coarse cellulosic
materials into the feed hopper.
7. A method for producing cellulose-based excipients
substantially as hereinbefore described with
reference to the accompanying drawing.
8. Cellulose-based excipients whenever produced by a
method as claimed in any preceding claim.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES960181 IES960181A2 (en) | 1996-02-29 | 1996-02-29 | Production method |
| GB9604564A GB2310856A (en) | 1996-02-29 | 1996-03-04 | Producing cellulose-based excipient |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IES960181 IES960181A2 (en) | 1996-02-29 | 1996-02-29 | Production method |
| GB9604564A GB2310856A (en) | 1996-02-29 | 1996-03-04 | Producing cellulose-based excipient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB9604564D0 GB9604564D0 (en) | 1996-05-01 |
| GB2310856A true GB2310856A (en) | 1997-09-10 |
Family
ID=26308857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9604564A Withdrawn GB2310856A (en) | 1996-02-29 | 1996-03-04 | Producing cellulose-based excipient |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB2310856A (en) |
| IE (1) | IES960181A2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022099666A1 (en) * | 2020-11-10 | 2022-05-19 | 苏州纳昇源新材料科技有限公司 | Crushing device for use in nanocellulose preparation and capable of effectively improving filtering efficiency of air filtering material |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1514788A (en) * | 1974-12-13 | 1978-06-21 | Hoechst Ag | Grinding method for cellulose |
-
1996
- 1996-02-29 IE IES960181 patent/IES960181A2/en not_active IP Right Cessation
- 1996-03-04 GB GB9604564A patent/GB2310856A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1514788A (en) * | 1974-12-13 | 1978-06-21 | Hoechst Ag | Grinding method for cellulose |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022099666A1 (en) * | 2020-11-10 | 2022-05-19 | 苏州纳昇源新材料科技有限公司 | Crushing device for use in nanocellulose preparation and capable of effectively improving filtering efficiency of air filtering material |
Also Published As
| Publication number | Publication date |
|---|---|
| IES68057B2 (en) | 1996-05-15 |
| IES960181A2 (en) | 1996-05-15 |
| GB9604564D0 (en) | 1996-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |