[go: up one dir, main page]

GB2307414B - Microporation of human skin for drug delivery and monitoring applications - Google Patents

Microporation of human skin for drug delivery and monitoring applications

Info

Publication number
GB2307414B
GB2307414B GB9702766A GB9702766A GB2307414B GB 2307414 B GB2307414 B GB 2307414B GB 9702766 A GB9702766 A GB 9702766A GB 9702766 A GB9702766 A GB 9702766A GB 2307414 B GB2307414 B GB 2307414B
Authority
GB
United Kingdom
Prior art keywords
microporation
drug delivery
human skin
monitoring applications
monitoring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB9702766A
Other versions
GB2307414A (en
GB9702766D0 (en
Inventor
Jonathan A Eppstein
Michael R Hatch
Difei Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spectrx Inc
Altea Technologies Inc
Original Assignee
Spectrx Inc
Altea Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrx Inc, Altea Technologies Inc filed Critical Spectrx Inc
Publication of GB9702766D0 publication Critical patent/GB9702766D0/en
Publication of GB2307414A publication Critical patent/GB2307414A/en
Application granted granted Critical
Publication of GB2307414B publication Critical patent/GB2307414B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3203—Fluid jet cutting instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00137—Details of operation mode
    • A61B2017/00154—Details of operation mode pulsed
    • A61B2017/00172—Pulse trains, bursts, intermittent continuous operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Surgical Instruments (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Laser Surgery Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB9702766A 1995-08-29 1996-08-29 Microporation of human skin for drug delivery and monitoring applications Expired - Lifetime GB2307414B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52054795A 1995-08-29 1995-08-29
US804395P 1995-10-30 1995-10-30
PCT/US1996/013865 WO1997007734A1 (en) 1995-08-29 1996-08-29 Microporation of human skin for drug delivery and monitoring applications

Publications (3)

Publication Number Publication Date
GB9702766D0 GB9702766D0 (en) 1997-04-02
GB2307414A GB2307414A (en) 1997-05-28
GB2307414B true GB2307414B (en) 1998-03-11

Family

ID=26677684

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9702766A Expired - Lifetime GB2307414B (en) 1995-08-29 1996-08-29 Microporation of human skin for drug delivery and monitoring applications

Country Status (13)

Country Link
EP (1) EP0858285A4 (en)
JP (2) JP3899427B2 (en)
CN (1) CN1174713C (en)
AU (1) AU707065B2 (en)
BR (1) BR9610012A (en)
CA (1) CA2199002C (en)
ES (1) ES2536459T3 (en)
GB (1) GB2307414B (en)
IL (1) IL123379A (en)
NO (1) NO334437B1 (en)
PT (1) PT1563788E (en)
TR (1) TR199800347T1 (en)
WO (1) WO1997007734A1 (en)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6315772B1 (en) 1993-09-24 2001-11-13 Transmedica International, Inc. Laser assisted pharmaceutical delivery and fluid removal
DE69719761T2 (en) 1996-06-18 2003-12-18 Alza Corp., Palo Alto DEVICE FOR IMPROVING THE TRANSDERMAL ADMINISTRATION OF MEDICINAL PRODUCTS OR THE DETECTION OF BODY LIQUIDS
AU3880697A (en) * 1996-07-03 1998-01-21 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
US5983136A (en) * 1996-09-17 1999-11-09 Deka Products Limited Partnership System for delivery of drugs by transport
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
CA2789115C (en) * 1996-12-31 2014-04-29 Altea Therapeutics Corporation Microporation of tissue for delivery of bioactive agents
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US6027496A (en) 1997-03-25 2000-02-22 Abbott Laboratories Removal of stratum corneum by means of light
CA2306728A1 (en) 1997-10-21 1999-04-29 Abbott Laboratories Apparatus and method for the collection of interstitial fluids
US6155992A (en) * 1997-12-02 2000-12-05 Abbott Laboratories Method and apparatus for obtaining interstitial fluid for diagnostic tests
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
KR100572539B1 (en) * 1997-12-11 2006-04-24 알자 코포레이션 Device for Enhancing Percutaneous Agent Flow Rate
WO1999029365A1 (en) * 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
KR100557261B1 (en) 1997-12-11 2006-03-07 알자 코포레이션 Device for Enhancing Percutaneous Agent Flow Rate
US6530915B1 (en) 1998-03-06 2003-03-11 Spectrx, Inc. Photothermal structure for biomedical applications, and method therefor
AU2898699A (en) * 1998-03-06 1999-09-20 Altea Technologies, Inc. Photothermal structure for biomedical applications, and method therefor
US6173202B1 (en) 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6569157B1 (en) * 1998-05-18 2003-05-27 Abbott Laboratories Removal of stratum corneum by means of light
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6077660A (en) * 1998-06-10 2000-06-20 Abbott Laboratories Diagnostic assay requiring a small sample of biological fluid
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
DE69939906D1 (en) 1998-07-14 2008-12-24 Altea Therapeutics Corp TRANSDERMAL TRANSPORT DEVICE FOR THE CONTROLLED REMOVAL OF BIOLOGICAL MEMBRANES BY PYROTECHNICAL LOADING
EP1098594B1 (en) * 1998-07-21 2007-12-12 SPECTRX, Inc. System and method for continuous analyte monitoring
US7384396B2 (en) 1998-07-21 2008-06-10 Spectrx Inc. System and method for continuous analyte monitoring
JP2002524120A (en) * 1998-09-04 2002-08-06 パウダージェクト リサーチ リミテッド Monitoring method using particle delivery method
US6468229B1 (en) 1998-10-20 2002-10-22 Abbott Laboratories Apparatus and method for the collection of interstitial fluids
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6597946B2 (en) 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
CA2376368C (en) * 1999-06-08 2009-08-11 Altea Technologies, Inc. Apparatus for microporation of biological membranes using thin film tissue interface devices, and method therefor
US20030078499A1 (en) 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US6355054B1 (en) * 1999-11-05 2002-03-12 Ceramoptec Industries, Inc. Laser system for improved transbarrier therapeutic radiation delivery
DE19963034A1 (en) 1999-12-24 2001-06-28 Roche Diagnostics Gmbh Glucose level detection system based on measurement of interstitial fluid, uses heating device or ultrasound to reduce time offset between concentration in interstitial fluid and blood
IL136008A0 (en) 2000-05-07 2001-05-20 Elecsys Ltd Electrically-mediated transdermal drug injection
US6706032B2 (en) 2000-06-08 2004-03-16 Massachusetts Institute Of Technology Localized molecular and ionic transport to and from tissues
US7597692B2 (en) 2000-06-08 2009-10-06 Massachusetts Institute Of Technology Microscission processes and procedures
AUPR044000A0 (en) * 2000-09-28 2000-10-26 Norwood Abbey Ltd Diagnostic device
US6537243B1 (en) 2000-10-12 2003-03-25 Abbott Laboratories Device and method for obtaining interstitial fluid from a patient for diagnostic tests
US6882884B1 (en) 2000-10-13 2005-04-19 Soundskin, L.L.C. Process for the stimulation of production of extracellular dermal proteins in human tissue
US6733493B2 (en) * 2000-11-16 2004-05-11 Innotech Usa, Inc. Laser skin perforator
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
AU2002231207A1 (en) 2000-12-21 2002-07-01 Biovalve Technologies, Inc. Microneedle array systems
CA2437899C (en) 2001-02-13 2012-05-15 Gregory M. Glenn Vaccine for transcutaneous immunization against etec-caused traveler's diarrhea
JP4704583B2 (en) * 2001-02-28 2011-06-15 有限会社開発顧問室 Patch test sheet
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
AU2002327675A1 (en) 2001-09-19 2003-04-01 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US8920375B2 (en) 2001-09-21 2014-12-30 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
AU2002353444A1 (en) 2001-11-07 2003-05-19 Transpharma Medical Ltd. Integrated transdermal drug delivery system
WO2003077970A2 (en) 2002-03-11 2003-09-25 Altea Therapeutics Corporation Transdermal integrated actuator device, methods of making and using same
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
WO2003089043A2 (en) 2002-04-19 2003-10-30 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd Transdermal delivery system for dried particulate or lyophilized medications
IL152575A (en) 2002-10-31 2008-12-29 Transpharma Medical Ltd Transdermal delivery system for water insoluble drugs
US7383084B2 (en) 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US7662404B2 (en) 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
US8133505B2 (en) 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152573A (en) 2002-10-31 2009-11-18 Transpharma Medical Ltd Transdermal delivery system for anti-emetic medication
US7258673B2 (en) 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
JP2007508914A (en) * 2003-10-24 2007-04-12 アルザ・コーポレーシヨン Apparatus and method for facilitating transdermal drug delivery
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
WO2005042054A2 (en) * 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
AU2005299759A1 (en) 2004-10-21 2006-05-04 Bayer Healthcare Llc Method of determining the concentration of an analyte in a body fluid and system therefor
JP2006326147A (en) * 2005-05-30 2006-12-07 Shingo Wakamatsu Laser therapy equipment
TWI419717B (en) * 2005-06-17 2013-12-21 Altea Therapeutics Corp Osmotic delivery system and method of use thereof
JP5011936B2 (en) * 2006-10-11 2012-08-29 パナソニック株式会社 Blood test equipment
JP5011935B2 (en) * 2006-10-11 2012-08-29 パナソニック株式会社 Blood test equipment
EP2103324B1 (en) * 2006-11-14 2013-07-03 Kagoshima University Drug injecting device
RU2328739C1 (en) * 2007-02-26 2008-07-10 Айрат Анварович Халиков Analysis of cadaver biological tissue cell membrane integrity
WO2008134545A1 (en) 2007-04-27 2008-11-06 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery
CA2704740C (en) 2007-10-09 2016-05-17 Transpharma Ltd. Magnetic patch coupling
CA2696227A1 (en) 2007-10-17 2009-04-23 Transpharma Medical Ltd. Dissolution rate verification
WO2009060701A1 (en) * 2007-11-06 2009-05-14 Konica Minolta Opto, Inc. Microopening forming apparatus and body liquid collecting system using the microopening forming apparatus
JP2011505899A (en) 2007-12-05 2011-03-03 シネロン メディカル リミテッド Disposable electromagnetic energy applicator and method of using the same
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
US20100256466A1 (en) * 2009-04-02 2010-10-07 Avraham Shekalim Metabolite Management System
PL2459092T3 (en) * 2009-07-27 2020-05-18 Novoxel Ltd. Device for tissue vaporization
PT105635B (en) 2011-04-19 2014-04-11 Univ De Coimbra DEVICE FOR THE EFFICIENT ADMINISTRATION OF COMPOUNDS IN THE SKIN OR BIOLOGICAL BARRIERS, OR THROUGH THEM, USING FINE ABSORBENT LIGHT FILMS
CN105939684B (en) 2013-12-18 2020-06-09 诺服塞尔有限公司 Apparatus and method for vaporizing tissue
KR20170058972A (en) * 2014-09-15 2017-05-29 노보셀 리미티드 Methods and devices for thermal surgical vaporization and incision of tissue
CN106999237B (en) 2014-09-15 2020-06-12 诺服塞尔有限公司 Method and apparatus for thermal tissue vaporization and compression
WO2016141144A1 (en) * 2015-03-03 2016-09-09 Guided Therapy Systems, Llc Methods and systems for material transport across an impermeable or semi-permeable membrane via artificially created microchannels
US10874325B2 (en) * 2015-12-15 2020-12-29 Koninklijke Philips N.V. Surface treatment device and method
WO2017123954A1 (en) * 2016-01-15 2017-07-20 University Of Cincinnati Advanced electroporation devices and methods for analyte access in biofluids
JP6989960B2 (en) * 2016-06-20 2022-02-03 ユニバーシティ・オブ・ノース・テキサス Laser Applied Machining of Non-Monolithic and Composite Bone Materials (LAM)
FI127811B (en) * 2016-11-21 2019-03-15 Helsingin Yliopisto Device for sampling one or more analytes
EP3361402B1 (en) * 2017-02-14 2024-12-04 Roche Diabetes Care GmbH A computer-implemented method and a portable device for analyzing glucose monitoring data indicative of a glucose level in a bodily fluid, and a non-transitory computer readable medium
US11441994B2 (en) * 2017-07-27 2022-09-13 Tata Consultancy Services Limited Method and system for in-silico design of skin electroporation
EP3691788A1 (en) * 2017-08-03 2020-08-12 FibroTx OÜ Lateral flow assay and device for skin care application
CN109157280A (en) * 2018-08-10 2019-01-08 重庆大学 Irreversible electroporated tissue ablation effect dynamic realtime assessment equipment
KR102651496B1 (en) * 2018-08-23 2024-03-25 카스텐 하게만 Use of alternating electric fields to improve brain-blood barrier permeability
JP7522140B2 (en) 2019-06-28 2024-07-24 パスポート テクノロジーズ、インコーポレイテッド Method and system for controlling heat delivery to a filament device - Patents.com
CN112294301B (en) * 2019-08-02 2024-12-31 华广生技股份有限公司 Physiological signal sensor device
CN110613893A (en) * 2019-10-31 2019-12-27 南京工业职业技术学院 Novel excitation coil
CN111693434B (en) * 2020-06-19 2024-01-19 中建路桥集团有限公司 Experimental device for test concrete impervious performance
CN114504373A (en) * 2020-11-16 2022-05-17 澳美力科技(成都)有限公司 Novel radio frequency conversion beauty instrument
CN112957124B (en) * 2021-01-30 2023-08-22 南京理工大学 In-vitro laser biological tissue welding and sewing method for energy targeting regulation and control
CN115670642A (en) * 2021-05-20 2023-02-03 黄虹凤 Laser cutting device that guarantees high precision and high speed
CN114343839B (en) * 2021-12-30 2024-07-23 德州环球之光医疗科技股份有限公司 Treatment pattern conversion method based on adjustable spiral linear laser spots
CN116999687B (en) * 2023-07-19 2024-11-12 河南翔宇医疗设备股份有限公司 Ultrasonic permeameter and ultrasonic permeameter output parameter setting device and medium

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775361A (en) * 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5019034A (en) * 1988-01-21 1991-05-28 Massachusetts Institute Of Technology Control of transport of molecules across tissue using electroporation
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
US5246437A (en) * 1992-04-10 1993-09-21 Abela George S Cell treatment apparatus and method
US5267985A (en) * 1993-02-11 1993-12-07 Trancell, Inc. Drug delivery by multiple frequency phonophoresis
WO1995010223A2 (en) * 1993-10-13 1995-04-20 Inomet, Inc. Interstitial fluid collection and constituent measurement
WO1997004832A1 (en) * 1995-07-25 1997-02-13 Massachusetts Institute Of Technology Enhanced transdermal transport using ultrasound

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863970A (en) * 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
GB9014307D0 (en) 1990-06-27 1990-08-15 Scient Generics Ltd Method of treatment and compositions therefor
JP3189337B2 (en) * 1991-11-08 2001-07-16 日本電気株式会社 Skin stratum corneum removal device and method
US5344418A (en) * 1991-12-12 1994-09-06 Shahriar Ghaffari Optical system for treatment of vascular lesions
US5165418B1 (en) * 1992-03-02 1999-12-14 Nikola I Tankovich Blood sampling device and method using a laser
US5643252A (en) * 1992-10-28 1997-07-01 Venisect, Inc. Laser perforator
US5279552A (en) * 1993-01-11 1994-01-18 Anton Magnet Intradermal injection device
US5458140A (en) 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
US5445611A (en) * 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775361A (en) * 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US5019034A (en) * 1988-01-21 1991-05-28 Massachusetts Institute Of Technology Control of transport of molecules across tissue using electroporation
US5019034B1 (en) * 1988-01-21 1995-08-15 Massachusetts Inst Technology Control of transport of molecules across tissue using electroporation
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5246437A (en) * 1992-04-10 1993-09-21 Abela George S Cell treatment apparatus and method
US5267985A (en) * 1993-02-11 1993-12-07 Trancell, Inc. Drug delivery by multiple frequency phonophoresis
WO1995010223A2 (en) * 1993-10-13 1995-04-20 Inomet, Inc. Interstitial fluid collection and constituent measurement
WO1997004832A1 (en) * 1995-07-25 1997-02-13 Massachusetts Institute Of Technology Enhanced transdermal transport using ultrasound

Also Published As

Publication number Publication date
IL123379A (en) 2002-04-21
CN1195276A (en) 1998-10-07
JP3899427B2 (en) 2007-03-28
NO980878L (en) 1998-04-27
JP2006192285A (en) 2006-07-27
HK1009321A1 (en) 1999-05-28
NO334437B1 (en) 2014-03-03
IL123379A0 (en) 1998-09-24
CN1174713C (en) 2004-11-10
ES2536459T3 (en) 2015-05-25
NO980878D0 (en) 1998-02-27
PT1563788E (en) 2015-06-02
WO1997007734A1 (en) 1997-03-06
EP0858285A4 (en) 2000-05-17
TR199800347T1 (en) 1998-05-21
JPH11511360A (en) 1999-10-05
AU6863196A (en) 1997-03-19
EP0858285A1 (en) 1998-08-19
CA2199002A1 (en) 1997-03-01
CA2199002C (en) 1999-02-23
GB2307414A (en) 1997-05-28
BR9610012A (en) 1999-12-21
AU707065B2 (en) 1999-07-01
GB9702766D0 (en) 1997-04-02

Similar Documents

Publication Publication Date Title
GB2307414B (en) Microporation of human skin for drug delivery and monitoring applications
GB2313310B (en) Local delivery and monitoring of drugs
AU6042696A (en) Drug delivery catheters and methods of use
AU1970495A (en) Drug delivery device and method of construction
AU3309097A (en) Reduction of skin sensitization in electrotransport drug delivery
HU9602583D0 (en) Gel for treatment of skin diseases and for disinfection of the skin
AU7133298A (en) Implantable medical device and method of manufacture
AU8933391A (en) Medical drug formulation and delivery system
HUP0104803A3 (en) Process and system for the administration of medicine through the skin
HUP9901890A3 (en) Medicament and method of treating an organism with medicaments
HUP9903144A3 (en) Medicament for treatment of inflammation containing il-10 and steroids
HUP9904294A3 (en) Topiramate derivatives and their use for producing medicament useful in the treatment of neuropathic pain
EP1563788B8 (en) Microporation of human skin for drug delivery and monitoring applications
AU6968098A (en) Topical treatment of skin diseases and eye afflictions
HK1009321B (en) Microporation of human skin for drug delivery and monitoring applications
ZA951789B (en) Pharmaceutical materials and methods of administration
AU3110789A (en) Applicator for skin-cleansing agents, skin care products and medical liniments
AU6786796A (en) Transilluminator for use in human and veterinary medicine
GB9401745D0 (en) Improvements in and relating to the administration of medicaments or therapeutic substances
HU9601096D0 (en) Pharmaceutical and medicine composition of anti-hiv activity based on medicinal plants
SI0774954T1 (en) Hydrogel for the application of therapeutic and/or cosmetic active substances to the skin
GB2318057B (en) Treatment of nocturnal polyuria and medicaments therefor
AU5778098A (en) Therapeutic substance for use in the treatment of aids and immuno-allergical diseases
GB9515826D0 (en) Treatment of nocturnal polyuria and medicaments therefor
GB9520159D0 (en) Benzoioc amide retinoids for use in the treatment of skin diseases and cancer

Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)

Free format text: REGISTERED BETWEEN 20150129 AND 20150204

732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)

Free format text: REGISTERED BETWEEN 20150205 AND 20150211

PE20 Patent expired after termination of 20 years

Expiry date: 20160828