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GB2300188A - Metalloproteinase inhibitors - Google Patents

Metalloproteinase inhibitors

Info

Publication number
GB2300188A
GB2300188A GB9611282A GB9611282A GB2300188A GB 2300188 A GB2300188 A GB 2300188A GB 9611282 A GB9611282 A GB 9611282A GB 9611282 A GB9611282 A GB 9611282A GB 2300188 A GB2300188 A GB 2300188A
Authority
GB
United Kingdom
Prior art keywords
metalloproteinase inhibitors
group
formula
matrix metalloproteinase
amide bonds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9611282A
Other versions
GB2300188B (en
GB9611282D0 (en
Inventor
Raymond Paul Beckett
Mark Whittaker
Andrew Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9401416A external-priority patent/GB9401416D0/en
Priority claimed from GB9413566A external-priority patent/GB9413566D0/en
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Priority to GB9721061A priority Critical patent/GB2315750B/en
Priority to GB9611282A priority patent/GB2300188B/en
Priority claimed from PCT/GB1995/000121 external-priority patent/WO1995019961A1/en
Publication of GB9611282D0 publication Critical patent/GB9611282D0/en
Publication of GB2300188A publication Critical patent/GB2300188A/en
Application granted granted Critical
Publication of GB2300188B publication Critical patent/GB2300188B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Matrix metalloproteinase inhibiting compounds of formula (I), wherein X is a -CO 2 H or -CONHOH group; and one of the groups proximate to the amide bonds is a steric bulky group, showing enhanced oral absorption.
GB9611282A 1994-01-22 1995-01-23 Metalloproteinase inhibitors Expired - Fee Related GB2300188B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB9721061A GB2315750B (en) 1994-01-22 1995-01-23 Metalloproteinase inhibitors
GB9611282A GB2300188B (en) 1994-01-22 1995-01-23 Metalloproteinase inhibitors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9401416A GB9401416D0 (en) 1994-01-22 1994-01-22 Metalloproteinase inhibitors
GB9413566A GB9413566D0 (en) 1994-07-06 1994-07-06 Metalloproteinase inhibitors
PCT/GB1995/000121 WO1995019961A1 (en) 1994-01-22 1995-01-23 Metalloproteinase inhibitors
GB9611282A GB2300188B (en) 1994-01-22 1995-01-23 Metalloproteinase inhibitors

Publications (3)

Publication Number Publication Date
GB9611282D0 GB9611282D0 (en) 1996-07-31
GB2300188A true GB2300188A (en) 1996-10-30
GB2300188B GB2300188B (en) 1998-07-01

Family

ID=27267031

Family Applications (2)

Application Number Title Priority Date Filing Date
GB9611282A Expired - Fee Related GB2300188B (en) 1994-01-22 1995-01-23 Metalloproteinase inhibitors
GB9721061A Expired - Fee Related GB2315750B (en) 1994-01-22 1995-01-23 Metalloproteinase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB9721061A Expired - Fee Related GB2315750B (en) 1994-01-22 1995-01-23 Metalloproteinase inhibitors

Country Status (1)

Country Link
GB (2) GB2300188B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0497192A2 (en) * 1991-02-01 1992-08-05 F. Hoffmann-La Roche Ag Amino acid derivatives
EP0575844A2 (en) * 1992-06-25 1993-12-29 F. Hoffmann-La Roche Ag Hydroxamic acid derivatives and pharmaceutical compositions thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69419473T2 (en) * 1993-04-27 2000-03-16 Celltech Therapeutics Ltd. PEPTIDYL DERIVATIVES AS INHIBITORS OF METALLOPROTEINASE
GB9308695D0 (en) * 1993-04-27 1993-06-09 Celltech Ltd Peptidyl derivatives
GB2299334B (en) * 1994-01-20 1998-05-13 British Biotech Pharm Metalloproteinase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0497192A2 (en) * 1991-02-01 1992-08-05 F. Hoffmann-La Roche Ag Amino acid derivatives
EP0575844A2 (en) * 1992-06-25 1993-12-29 F. Hoffmann-La Roche Ag Hydroxamic acid derivatives and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
GB2315750B (en) 1998-07-01
GB9721061D0 (en) 1997-12-03
GB2300188B (en) 1998-07-01
GB9611282D0 (en) 1996-07-31
GB2315750A (en) 1998-02-11

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20000123