GB2293547A - Compositions containing tea tree oil - Google Patents
Compositions containing tea tree oil Download PDFInfo
- Publication number
- GB2293547A GB2293547A GB9419571A GB9419571A GB2293547A GB 2293547 A GB2293547 A GB 2293547A GB 9419571 A GB9419571 A GB 9419571A GB 9419571 A GB9419571 A GB 9419571A GB 2293547 A GB2293547 A GB 2293547A
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- United Kingdom
- Prior art keywords
- oil
- plants
- medicament
- treatment
- infections
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- 239000000203 mixture Substances 0.000 title abstract description 5
- 239000010677 tea tree oil Substances 0.000 title description 15
- 229940111630 tea tree oil Drugs 0.000 title description 15
- 241000196324 Embryophyta Species 0.000 claims abstract description 24
- 241000378467 Melaleuca Species 0.000 claims abstract description 15
- 206010048685 Oral infection Diseases 0.000 claims abstract description 13
- 241000366182 Melaleuca alternifolia Species 0.000 claims abstract description 8
- 208000007565 gingivitis Diseases 0.000 claims abstract description 8
- 208000025865 Ulcer Diseases 0.000 claims abstract description 7
- 231100000397 ulcer Toxicity 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims abstract description 4
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 4
- 238000011282 treatment Methods 0.000 claims description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 239000003814 drug Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 14
- 201000001245 periodontitis Diseases 0.000 claims description 14
- 206010018785 Gingival infections Diseases 0.000 claims description 5
- 208000002399 aphthous stomatitis Diseases 0.000 claims description 5
- 241000378515 Melaleuca bracteata Species 0.000 claims description 3
- 241000378562 Melaleuca uncinata Species 0.000 claims description 3
- 240000007794 Melaleuca viridiflora Species 0.000 claims description 3
- 239000008180 pharmaceutical surfactant Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 208000028169 periodontal disease Diseases 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 239000004094 surface-active agent Substances 0.000 abstract description 3
- 239000003921 oil Substances 0.000 description 29
- 208000015181 infectious disease Diseases 0.000 description 7
- 208000006595 Necrotizing Ulcerative Gingivitis Diseases 0.000 description 6
- 239000002324 mouth wash Substances 0.000 description 6
- 229940051866 mouthwash Drugs 0.000 description 6
- 239000004098 Tetracycline Substances 0.000 description 4
- 229960002180 tetracycline Drugs 0.000 description 4
- 229930101283 tetracycline Natural products 0.000 description 4
- 235000019364 tetracycline Nutrition 0.000 description 4
- 150000003522 tetracyclines Chemical class 0.000 description 4
- 206010028813 Nausea Diseases 0.000 description 3
- 229960000282 metronidazole Drugs 0.000 description 3
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 3
- 230000008693 nausea Effects 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 230000003239 periodontal effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- 206010007134 Candida infections Diseases 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- 206010017533 Fungal infection Diseases 0.000 description 2
- 241000250507 Gigaspora candida Species 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 244000011376 Leptospermum laevigatum Species 0.000 description 2
- 235000017865 Leptospermum laevigatum Nutrition 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 201000003984 candidiasis Diseases 0.000 description 2
- 229960003260 chlorhexidine Drugs 0.000 description 2
- 229960005233 cineole Drugs 0.000 description 2
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 description 2
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 239000002563 ionic surfactant Substances 0.000 description 2
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical group CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 2
- 210000004261 periodontium Anatomy 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000011477 surgical intervention Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 150000003505 terpenes Chemical class 0.000 description 2
- 235000007586 terpenes Nutrition 0.000 description 2
- 229940116411 terpineol Drugs 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 241000238876 Acari Species 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010003399 Arthropod bite Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000244203 Caenorhabditis elegans Species 0.000 description 1
- 208000003643 Callosities Diseases 0.000 description 1
- 201000006082 Chickenpox Diseases 0.000 description 1
- 208000010445 Chilblains Diseases 0.000 description 1
- 206010008528 Chillblains Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000006004 Flea Infestations Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 206010022013 Ingrowing nail Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 206010027627 Miliaria Diseases 0.000 description 1
- 206010055670 Necrotising ulcerative gingivostomatitis Diseases 0.000 description 1
- 208000007027 Oral Candidiasis Diseases 0.000 description 1
- 208000005141 Otitis Diseases 0.000 description 1
- 208000005888 Periodontal Pocket Diseases 0.000 description 1
- 241001674048 Phthiraptera Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241001180364 Spirochaetes Species 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 208000025371 Taste disease Diseases 0.000 description 1
- 206010043183 Teething Diseases 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000893966 Trichophyton verrucosum Species 0.000 description 1
- 241000287411 Turdidae Species 0.000 description 1
- 206010046980 Varicella Diseases 0.000 description 1
- 208000000260 Warts Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 201000009329 acute pericementitis Diseases 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940045373 chlorhexidine mouthwash Drugs 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 210000003464 cuspid Anatomy 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 208000019258 ear infection Diseases 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 210000000003 hoof Anatomy 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000019656 metallic taste Nutrition 0.000 description 1
- FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 230000036346 tooth eruption Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
Compositions containing oil from plants of the genus MELALEUCA (tea tree) have activity against oral infections e.g ulcers, gingivitis and periodontal disease. The preferred compositions comprise the oil, water and a surfactant.
Description
TREATMENT OF ORAL INFECTIONS
The present invention relates to substances and compositions for use in the treatment of oral infections, especially gingival infections, periodontal infections and ulcers, particulary types of gingivitis including acute necrotising ulcerative gingivitis, periodontitis and aphthous ulcers.
Tea tree oil, also known as Melaleuca oil, is obtained from the leaves of the Australian tea tree, Melaleuca alternifolia. The oil is sometimes referred to as
Australian tea tree oil, oleum Melaleucae or ti-tree oil.
The entry for Melaleuca oil on page 1385 of Martindale
The Extra Pharmacopoeia (13th edition) ed. Reynolds J.E.F.,
The Pharmaceutical Press, London (1993) states that the oil is reported to have bactericidal and fungicidal properties.
The oil can be used topically to treat a variety of skin disorders.
Tea tree oil is also known to be useful in surgery, medicine and dentistry and the oil has been included in some medicated soaps and dentrifices.
Tea tree oil has been used with beneficial effect in the treatment of a variety of human ailments and conditions. For example, dandruff, blisters, corns, bruises, burns, insect bites, ringworm, minor finger infections, pierced ear infections, fungal infections such as athletes foot, ingrowing hair, ingrowing toenails, warts, dermatitis, eczema, shingles, psoriasis, heat rash, itching, spots, acne, cuts, grazes, chicken pox, headache, blocked sinuses, the common cold, influenza, sprains and strains, haemorrhoids and teething in infants.
There are a number of commercially available preparations which include tea tree oil. These preparations are Secaderm produced by Fisons for the treatment of chilblains, Soothene produced by Lane for the treatment of minor skin disorders and Tuberol syrup produced by Bouteille (France) for the treatment of coughs.
The oil has found use as an insect repellant and in saunas where it is dispersed into the air. The oil is also known to have veterinary applications in the treatment of hot spots, flea infestation, infected flea bites, ticks, lice, hoof thrush, skin irritations and roundworm.
Acute necrotising ulcerative gingivitis, also called
Vincent's infection or trench mouth, is an oral infection which is known to be caused by fusiform bacteria and spirochaetes. Metronidazole is known to be useful in treating acute necrotising ulcerative gingivitis.
Metronidazole is given to the patient orally in 200mg doses three times daily for three days. Similar doses are used in acute dental infections. Metronidazole has a number of adverse effects on patients and these are generally doserelated. The most common are gastro-intestinal disturbances, especially nausea. The nausea is sometimes accompanied by headache, anorexia and vomiting. An unpleasant metallic taste may be experienced. Where high doses or prolonged treatments are undertaken, peripheral neuropathy, usually presenting itself as a numbness or tingling of the extremities occurs. Also, epileptic-like seizures and serious adverse effects on the nervous system have been encountered.
Periodontal diseases are infections of the periodontium which may progress. Tetracycline can be used systemically in the treatment of periodontal disease but on termination of the treatment the benefits are limited. The infection can reoccur and the antibiotic does not take the place of active periodontal treatment e.g. curettage and surgery. The topical application of tetracycline to an infected region is also known to be effective. In the topical treatment, absorbent fibrous material loaded with tetracycline is tied around the teeth of a patient which are associated with the infection. However, this method of treatment suffers from the drawback that it is time consuming and awkward for the patient. Systemic tetracycline administration can also give rise to side effects such as nausea, vomiting and diarrhoea.The patient can become resistant to this antibiotic with continual topical treatment.
In less severe cases of gingivitis, a chlorhexidine mouthwash or dental gel is known to be a useful treatment.
Chlorhexidine at 0.1% (w/v) to 0.2% (w/v) used two or three times daily is known to reduce gingivitis and periodontal disease. Chlorhexidine suffers from the disadvantage that its use is limited by its unpleasant taste and staining properties.
The inventor has found that tea tree oil can be used to treat oral infections effectively and apart from an unpleasant taste, the oil has no apparent side effects.
Accordingly, the present invention provides the use of oil obtained from plants of the genus Melaleuca in the manufacture of a medicament for the treatment of oral infections. The term oral infection also includes fungal infections e.g. Candida infections. The medicament is preferably of use in the treatment of ulcers, gingival infections including acute necrotising ulcerative gingivitis, and periodontal infections. In particular, the medicament may be used in the treatment of aphthous ulcers, gingivitis and periodontitis.
The plants are preferably those which are commonly known as tea trees. The plants may also be known by the name Australian Melaleuca.
The plants may be one or more of Melaleuca alternifolia, M. uncinata, M. caiDuti, M. viridiflora, M.
cruinauenervia and M. bracteata.
The oil may be obtained from a single plant or from a number of individual plants. When the oil is obtained from a number of individual plants, the plants are preferably of the same species. However, the plants may comprise more than one species of Melaleuca.
The oil is preferably obtained from the leaves of the plants but the oil may also be obtained from any other oil bearing parts such as whole shoots and stems. Preferably, the oil is distilled from the oil bearing parts. Prior to distillation the oil bearing parts may be pressed or crushed in order to release the oil from the plant.
Alternatively, the plant parts may comminuted and extracted with water or an organic solvent before distillation.
Melaleuca oil which is a preferred oil is known to comprise about 50 to 60% by weight of terpenes, up to 10% by weight cineole and some terpineol. Other oils which may be used in the present invention may comprise terpenes, cineole and terpineol in different proportions to that found in Melaleuca oil.
The medicament is preferably in the form of a liquid comprising tea tree oil, water and a pharmaceutically acceptable surfactant. The surfactant is preferably a nonionic surfactant although a suitable ionic surfactant may be used. More than one surfactant may be present and both ionic and non-ionic surfactants may be present together. A preferred non-ionic surfactant is nonylphenol.
The medicament may further comprise an alcohol and a preferred alcohol is ethanol. Other pharmaceutically acceptable alcohols may be used instead of ethanol or in combination with ethanol. The medicament may also further comprise an ethoxylate.
The present invention also provides a method of treating oral infections comprising exposing diseased areas of the patient to oil obtained from plants of the genus
Melaleuca. The oral infections may be ulcers, gingival infections and periodontal infections, particularly aphthous ulcers, gingivitis and periodontitis. The oral infection may be fungal e.g. Candida. The oil is preferably in the form of a medicament as hereinbefore described.
Preferably, the medicament may be applied to the periodontal tissues and gums of the patient in the form of a mouthwash. When the medicament is to be used as a mouthwash it is preferably diluted to a suitable working strength with water. Alternatively, the medicament may be applied directly to the infected areas of the patient using an absorbent material such as cotton wool, an interdental appliance or various types of dental floss.
The invention will now be described with reference to the following example.
EXAMPLE 1 The treatment of acute destructive Periodontal disease (Periodontitis Complex TyDe IV)
with Australian Melaleuca oil.
An elderly male patient suffering from severe periodontal disease (Periodontitis Complex Type IV) was treated with tea tree oil. The oil used was the commercially available Thursday Plantation tea tree oil antiseptic, mild strength formulation, comprising 15% (v/v)
Australian Melaleuca oil (tea tree oil). (Thursday
Plantation P/L., Pacific Highway, Ballina 2478, Australia.)
The tea tree oil solution also comprises water, nonylphenol, an ethoxylate and ethanol.
A previous attempt at treating the patient's condition with a standard treatment of oral hygiene and visits to a dental hygienist for a period of 28 days was unsuccessful.
At the start of the tea tree oil treatment the patient had deep pockets of infection around his teeth and his gums were swollen, painful and bleeding. Several teeth were loose. Surgical intervention was proposed in order to remove the swollen and infected periodontal tissues throughout the periodontium. At this time root and epithelial curettage were also planned to further remove the infected tissues and the infected root surface.
As an alternative to the surgical intervention, a mouthwash of tea tree oil solution was made up by diluting 1 part of solution from the bottle with approximately 1 part tap water. The patient took a mouthful of mouthwash and agitated this in his mouth for approximately 2 minutes after which time the mouthwash was released by the patient from his mouth. The mouthwash treatment was repeated twice daily for 28 days accompanied by good oral hygiene maintenance by the patient. At the end of the treatment the patient's teeth and gums appeared to be in a healthy condition. The periodontal infection was resolved. The gingivae had a normal appearance and the periodontal pockets had reduced 3-5mm in areas which were previously severely infected.
EXAMPLE 2
A female patient aged 63, a periodontist, noted a periodontal infection between the lower right lateral and cuspid teeth. The gum tissue was swollen, bleeding and painful.
The infected area was treated repeatedly by the direct application of tea tree oil on an interdental appliance over a period of two days. The lesion totally resolved after two days treatment and did not recur. The periodontist considered that this confirmed the result of
Example 1.
Claims (24)
1. The use of oil obtained from plants of the genus
Melaleuca in the manufacture of a medicament for the treatment of oral infections.
2. A use as claimed in Claim 1, wherein the medicament is for the treatment of ulcers, gingival infections and periodontal infections.
3. A use as claimed in Claim 2, wherein the medicament is for the treatment of aphthous ulcers, gingivitis and periodontitis.
4. A use as claimed in any one of Claims 1 to 3, wherein the plants are tea trees.
5. A use as claimed in Claim 4, wherein the plants are
Australian Melaleucas.
6. A use as claimed in any one of Claims 1 to 3, wherein the plants are one or more of Melaleuca alternifolia, M.
uncinata, M. ca1outi, M. viridiflora, M. auinauenervia and
M. bracteata.
7. A use as claimed in any one of Claims 1 to 6, wherein the oil is obtained from the leaves of the plants.
8. A use as claimed in Claim 7, wherein the oil is distilled from the leaves.
9. A use as claimed in any preceding claim, wherein the medicament is a solution comprising the oil, water and a pharmaceutically acceptable surfactant.
10. A use as claimed in Claim 9, wherein the medicament further comprises an alcohol.
11. A use as claimed in Claim 9 or Claim 10, wherein the alcohol is ethanol.
12. A use as claimed in any one of Claims 9 to 11, wherein the medicament further comprises an ethoxylate.
13. A method of treating oral infection comprising exposing diseased areas of the patient to oil obtained from plants of the genus Melaleuca.
14. A method as claimed in Claim 13, wherein the oral infection is an ulcer or ulcers, gingival infection or periodontal infection.
15. A method as claimed in Claim 14, wherein the oral infection is aphthous ulcers, gingivitis or periodontitis.
16. A method as claimed in any one of Claims 13 to 15, wherein the plants are tea trees.
17. A method as claimed in Claim 16, wherein the plants are Australian Melaleucas.
18. A method as claimed in any one of Claims 13 to 15, wherein the plants are one or more of Melaleuca alternifolia, M. uncinata, M. calputi, M. viridiflora, M.
quinauenervia and M. bracteata.
19. A method as claimed in any one of Claims 13 to 18, wherein the oil is obtained from the leaves of the plants.
20. A method as claimed in Claim 19, wherein the oil is distilled from the leaves.
21. A method as claimed in Claim 20, wherein the oil is part of a solution comprising the oil, water and a pharmaceutically acceptable surfactant.
22. A method as claimed in Claim 21, wherein the solution further comprises an alcohol.
23. A method as claimed in Claim 22, wherein the alcohol is ethanol.
24. A method as claimed in any one of Claims 21 to 23, wherein the solution further comprises an ethoxylate.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9419571A GB2293547A (en) | 1994-09-27 | 1994-09-27 | Compositions containing tea tree oil |
| AU35304/95A AU3530495A (en) | 1994-09-27 | 1995-09-25 | Treatment of periodontal and acute gingival infections |
| PCT/GB1995/002281 WO1996009834A1 (en) | 1994-09-27 | 1995-09-25 | Treatment of periodontal and acute gingival infections |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9419571A GB2293547A (en) | 1994-09-27 | 1994-09-27 | Compositions containing tea tree oil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB9419571D0 GB9419571D0 (en) | 1994-11-16 |
| GB2293547A true GB2293547A (en) | 1996-04-03 |
Family
ID=10762030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9419571A Withdrawn GB2293547A (en) | 1994-09-27 | 1994-09-27 | Compositions containing tea tree oil |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU3530495A (en) |
| GB (1) | GB2293547A (en) |
| WO (1) | WO1996009834A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5826546A (en) * | 1997-04-23 | 1998-10-27 | Miraclecorp Of Australia | Method for shampooing a pet using a foam-dispensed pet shampoo composition |
| WO1999048511A1 (en) * | 1998-03-24 | 1999-09-30 | Farmila - Farmaceutici Milano S.R.L. | Antifungal and antibacterial compositions containing melaleuca essential oil |
| EP1126861A2 (en) * | 1998-11-03 | 2001-08-29 | Safe 'n Sound Solutions, Inc. | Compositions comprising oleum melaleuca |
| US8039512B2 (en) | 2003-06-04 | 2011-10-18 | Athol Gillies Turner | Biologically active oils |
| WO2016181355A1 (en) * | 2015-05-14 | 2016-11-17 | Roberto Logi | Compositions for treating and/or preventing psoriasis, prickly heat, dermatitises, neurofibromatosis type 1 and other pathologies of the dermis, mucosae, and oral cavity |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPN815696A0 (en) * | 1996-02-20 | 1996-03-14 | Stacey, T.K. | Anti-microbial composition |
| US20230048169A1 (en) * | 2020-07-20 | 2023-02-16 | Javad Ghoreishi | Oral hygiene compositions |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4925655A (en) * | 1988-03-04 | 1990-05-15 | Robell Research | Powder composition for forming a mouthwash |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU559001B2 (en) * | 1980-09-05 | 1987-02-19 | Sedgewick, S.E. | Skin cream containing tea tree oil |
| FR2618670B1 (en) * | 1987-07-28 | 1990-08-17 | Philip Gerard | MEDICINAL PREPARATION BASED ON ESSENTIAL OILS, AS WELL AS DENTAL AND CHEWING GUM CONTAINING THE SAME |
| FR2705571A1 (en) * | 1993-05-24 | 1994-12-02 | Perez Adrien Guy | Combination of a fatty oil and one or more aromatic essential oils |
-
1994
- 1994-09-27 GB GB9419571A patent/GB2293547A/en not_active Withdrawn
-
1995
- 1995-09-25 WO PCT/GB1995/002281 patent/WO1996009834A1/en active Application Filing
- 1995-09-25 AU AU35304/95A patent/AU3530495A/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4925655A (en) * | 1988-03-04 | 1990-05-15 | Robell Research | Powder composition for forming a mouthwash |
Non-Patent Citations (1)
| Title |
|---|
| Biosis Abstract No.97400125 & Oral Microbiol and Immunol. 9(4), 1994, pages 202-208 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5826546A (en) * | 1997-04-23 | 1998-10-27 | Miraclecorp Of Australia | Method for shampooing a pet using a foam-dispensed pet shampoo composition |
| WO1999048511A1 (en) * | 1998-03-24 | 1999-09-30 | Farmila - Farmaceutici Milano S.R.L. | Antifungal and antibacterial compositions containing melaleuca essential oil |
| EP1126861A2 (en) * | 1998-11-03 | 2001-08-29 | Safe 'n Sound Solutions, Inc. | Compositions comprising oleum melaleuca |
| EP1126861A4 (en) * | 1998-11-03 | 2003-05-02 | Safe N Sound Solutions Inc | Compositions comprising oleum melaleuca |
| US8039512B2 (en) | 2003-06-04 | 2011-10-18 | Athol Gillies Turner | Biologically active oils |
| US8329748B2 (en) | 2003-06-04 | 2012-12-11 | Athol Gillies Turner | Biologically active oils |
| US8629181B2 (en) | 2003-06-04 | 2014-01-14 | Athol Gillies Turner | Biologically active oils |
| WO2016181355A1 (en) * | 2015-05-14 | 2016-11-17 | Roberto Logi | Compositions for treating and/or preventing psoriasis, prickly heat, dermatitises, neurofibromatosis type 1 and other pathologies of the dermis, mucosae, and oral cavity |
Also Published As
| Publication number | Publication date |
|---|---|
| AU3530495A (en) | 1996-04-19 |
| GB9419571D0 (en) | 1994-11-16 |
| WO1996009834A1 (en) | 1996-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |