[go: up one dir, main page]

GB2286189A - Recombinant specific binding protein - Google Patents

Recombinant specific binding protein

Info

Publication number
GB2286189A
GB2286189A GB9507442A GB9507442A GB2286189A GB 2286189 A GB2286189 A GB 2286189A GB 9507442 A GB9507442 A GB 9507442A GB 9507442 A GB9507442 A GB 9507442A GB 2286189 A GB2286189 A GB 2286189A
Authority
GB
United Kingdom
Prior art keywords
binding
protein
binding protein
binding regions
domains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB9507442A
Other versions
GB9507442D0 (en
Inventor
William Joseph Harris
Stephen Charles Emery
Gregory Paul Winter
Francis Joseph Carr
Duncan Patrick Mcgregor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SCOTGEN Ltd
Original Assignee
SCOTGEN Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929221657A external-priority patent/GB9221657D0/en
Application filed by SCOTGEN Ltd filed Critical SCOTGEN Ltd
Priority to GB9507442A priority Critical patent/GB2286189A/en
Publication of GB9507442D0 publication Critical patent/GB9507442D0/en
Publication of GB2286189A publication Critical patent/GB2286189A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A specific binding protein having first and second binding regions, e.g. antibody Fv fragments, which specifically recognise and bind to target entities, said binding regions being contained at least in part on respectively first and second polypeptide chains, said chains additionally incorporating respectively first and second associating domains, e.g. antibody VH and VL domains, which are capable of binding to each other, causing the first and second polypeptide chains to combine, thereby providing a single protein incorporating the binding specificities of said first and second binding regions. The first and second binding regions may recognise different target entities, giving a bispecific binding protein. Preferably the associating domains are derived from a human protein (i.e. one which has been exposed to the human immune system), so that the protein is less likely to provoke the human immune system when administered therapeutically. The binding protein is suitably produced by recombinant DNA expression. <IMAGE>
GB9507442A 1992-10-15 1993-10-15 Recombinant specific binding protein Withdrawn GB2286189A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9507442A GB2286189A (en) 1992-10-15 1993-10-15 Recombinant specific binding protein

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929221657A GB9221657D0 (en) 1992-10-15 1992-10-15 Recombinant bispecific antibodies
PCT/GB1993/002133 WO1994009131A1 (en) 1992-10-15 1993-10-15 Recombinant specific binding protein
GB9507442A GB2286189A (en) 1992-10-15 1993-10-15 Recombinant specific binding protein

Publications (2)

Publication Number Publication Date
GB9507442D0 GB9507442D0 (en) 1995-05-31
GB2286189A true GB2286189A (en) 1995-08-09

Family

ID=26301800

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9507442A Withdrawn GB2286189A (en) 1992-10-15 1993-10-15 Recombinant specific binding protein

Country Status (1)

Country Link
GB (1) GB2286189A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002285A1 (en) * 1981-12-21 1983-07-07 Boston Biomed Res Inst Bispecific antibody determinants
EP0453082A1 (en) * 1990-03-09 1991-10-23 Hybritech Incorporated Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
WO1991019739A1 (en) * 1990-06-11 1991-12-26 Celltech Limited Multivalent antigen-binding proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002285A1 (en) * 1981-12-21 1983-07-07 Boston Biomed Res Inst Bispecific antibody determinants
EP0453082A1 (en) * 1990-03-09 1991-10-23 Hybritech Incorporated Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
WO1991019739A1 (en) * 1990-06-11 1991-12-26 Celltech Limited Multivalent antigen-binding proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOCHEMISTRY Vol. 31, No. 6, 1988, pages 1579-1584 *
BIOTECHNOLOGY Vol. 10, 1992, pages 163-167 *
EMBO JOURNAL Vol. 10, No. 12, 1991, pages 3655-3659 *

Also Published As

Publication number Publication date
GB9507442D0 (en) 1995-05-31

Similar Documents

Publication Publication Date Title
WO1995016038A3 (en) Humanized antibodies and uses thereof
Terry et al. Subclasses of human γ2-globulin based on differences in the heavy polypeptide chains
NZ303375A (en) Monoclonal antibodies specific for different epitopes of human gp39 and diagnostic and therapeutic methods using them
ZA891861B (en) Monoclonal antibodies
CA2212750A1 (en) Humanized antibodies against cd3
AU735411C (en) Stable lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies
ATE384792T1 (en) ANTIBODY VARIANTS WITH HIGHER BINDING AFFINITIES COMPARED TO PARENTAL ANTIBODIES
CA2128511A1 (en) Monomeric and dimeric antibody-fragment fusion proteins
NZ508381A (en) Antibodies, antagonists and agonists of the death domain containing receptor 5 (DR5)
DE69414870D1 (en) ANTIBODY WITH CHANGED TARGET DIRECTION
EP1350799A3 (en) Inhibitory Immunoglobulin Polypeptides to Human PDGF Beta Receptor
FR2669338B1 (en)
CA2068222A1 (en) Monoclonal antibodies
AU3342397A (en) Polypeptides capable of forming antigen binding structures with specificity for the rhesus d antigens, the dna encoding them and the process for their preparation and use
DE69535855D1 (en) CALCIUM BINDING RECOMBINANT ANTIBODIES TO PROTEIN C
ATE122894T1 (en) USE AND COMPOSITION FOR IMPROVING THE TARGETING OF ANTIBODIES, ANTIBODY PARTS, AND CONJUGATES THEREOF.
GB9311454D0 (en) Pharmaceutical compositions
WO1994004675A3 (en) Dna sequence encoding a novel member of the steroid and thyroid hormone receptor family
GB2286189A (en) Recombinant specific binding protein
AU641736B2 (en) Delivery of agents
AU5809290A (en) Monoclonal antibodies involved in alzheimer&#39;s disease, hybridomas secreting these monoclonal antibodies, antigen recognized by these antibodies, and their application
WO1997004098A3 (en) MODIFIED HUMAN CHORIONIC (β-hCG) PROTEINS AND THEIR MEDICAL USE
Mizutani et al. Effector functions of a mouse IgG that lacks the entire CH1 domain. C1q binding and complement fixation in the absence of antigen.
WO1999019480A3 (en) Human receptor proteins; related reagents and methods
GB2333295A (en) Modified protein G and fragments thereof

Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)