GB2249937B - Solutions for the perfusion, preservation and reperfusion of organs - Google Patents

Solutions for the perfusion, preservation and reperfusion of organs

Info

Publication number: GB2249937B
Authority: GB; United Kingdom
Prior art keywords: reperfusion; perfusion; organs; preservation; solutions
Prior art date: 1990-11-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

GB9124488A

Other versions

GB2249937A (en

GB9124488D0 (en

Inventor

Philippe Menasche

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Pasteur SA

Original Assignee

Pasteur Merieux Serum et Vaccines SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-20

Filing date

1991-11-18

Publication date

1994-02-16

1990-11-20 Priority claimed from FR9014424A external-priority patent/FR2669189B1/en

1991-07-17 Priority claimed from FR9109027A external-priority patent/FR2679107B1/en

1991-11-18 Application filed by Pasteur Merieux Serum et Vaccines SA filed Critical Pasteur Merieux Serum et Vaccines SA

1992-01-08 Publication of GB9124488D0 publication Critical patent/GB9124488D0/en

1992-05-27 Publication of GB2249937A publication Critical patent/GB2249937A/en

1994-02-16 Application granted granted Critical

1994-02-16 Publication of GB2249937B publication Critical patent/GB2249937B/en

2011-11-18 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Environmental Sciences (AREA)
Zoology (AREA)
Dentistry (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Inorganic Chemistry (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

GB9124488A 1990-11-20 1991-11-18 Solutions for the perfusion, preservation and reperfusion of organs Expired - Lifetime GB2249937B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9014424A FR2669189B1 (en)	1990-11-20	1990-11-20	PERFUSION AND STORAGE SOLUTIONS FOR CARDIAC TRANSPLANTATIONS.
FR9109027A FR2679107B1 (en)	1991-07-17	1991-07-17	ORGANIC PERFUSION, PRESERVATION AND REPERFUSION SOLUTIONS.

Publications (3)

Publication Number	Publication Date
GB9124488D0 GB9124488D0 (en)	1992-01-08
GB2249937A GB2249937A (en)	1992-05-27
GB2249937B true GB2249937B (en)	1994-02-16

Family

ID=26228338

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB9124488A Expired - Lifetime GB2249937B (en)	1990-11-20	1991-11-18	Solutions for the perfusion, preservation and reperfusion of organs

Country Status (8)

Country	Link
AT (1)	AT399440B (en)
BE (1)	BE1006834A3 (en)
CA (1)	CA2055827C (en)
CH (1)	CH683485A5 (en)
DE (1)	DE4138040A1 (en)
ES (1)	ES2050580B1 (en)
GB (1)	GB2249937B (en)
IT (1)	IT1251995B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH686870A5 (en) *	1992-09-18	1996-07-31	Pasteur Merieux Serums Vacc	infusion solution, preservation and organ perfusion.
DE69426295T2 (en) *	1993-05-07	2001-04-05	Chugai Seiyaku K.K., Tokio/Tokyo	ORGAN PRESERVATIVES
DE4325547C2 (en) *	1993-07-29	1997-11-27	Max Planck Gesellschaft	Use of thiol compounds for the therapy of hepatitis-virus-induced diseases
JPH07215801A (en) *	1994-01-28	1995-08-15	Senju Pharmaceut Co Ltd	Preservative for lung and method for preserving lung
JPH07330501A (en) *	1994-06-14	1995-12-19	Senju Pharmaceut Co Ltd	Liver preservative and liver preservation method
DE4439477C2 (en) *	1994-11-08	1999-10-21	Asta Medica Ag	Use of R, S - (+/-) - alpha-lipoic acid, R - (+) - alpha-lipoic acid, S - (-) - alpha-lipoic acid in reduced or oxidized form or the metabolites and their salts, esters, amides for the treatment of diabetic microangiopathy
DE19706111C2 (en) *	1997-02-17	1999-02-18	Fresenius Medical Care De Gmbh	Solution for storage of organs
US5990153A (en) *	1997-05-05	1999-11-23	Wood; John G.	Ultrasonicated α-lipoic acid solutions for attenuating microvascular injury
US6045990A (en) *	1998-07-09	2000-04-04	Baust; John M.	Inclusion of apoptotic regulators in solutions for cell storage at low temperature
DE19834087C1 (en) *	1998-07-29	2000-03-30	Mirzaie Sedaposhteh Massoud	Aqueous preservative solution for storage of animal tissue, especially porcine heart valves, contains sodium, potassium, magnesium and calcium salts, glucose and chelate former
GB0028414D0 (en)	2000-11-22	2001-01-03	Univ Leeds	Flush preservation solution
DE102007026392A1 (en)	2007-06-06	2008-12-11	Bayer Healthcare Ag	Solutions for the perfusion and preservation of organs and tissues
GR20180100514A (en) *	2018-11-07	2020-06-15	Πανεπιστημιο Πατρων	Pharmaceutical combinations and kits for the prevention or therapy of pain and other complications of orthopedic or vascular surgery and multiple trauma

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4423600A (en) *	1982-12-10	1984-01-03	Mckenna Joan J	Method for preservation of living organic tissue by freezing
US4473552A (en) *	1981-03-16	1984-09-25	Jost Leonora I	Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4186253A (en) *	1978-10-10	1980-01-29	The Green Cross Corporation	Perfusate for preserving organ to be transplanted and preserving method
SE8403912D0 (en) *	1984-07-30	1984-07-30	Pharmacia Ab	PHARMACEUTICAL KIT OR COMPOSITION
EP0215138B1 (en) *	1985-09-06	1991-01-16	Societe Des Produits Nestle S.A.	Preservation of living tissues
US4798824A (en) *	1985-10-03	1989-01-17	Wisconsin Alumni Research Foundation	Perfusate for the preservation of organs
US4879283A (en) *	1985-10-03	1989-11-07	Wisconsin Alumni Research Foundation	Solution for the preservation of organs
ES2007994A6 (en) *	1988-08-16	1989-07-01	Grino Boira Jose Maria	LIQUID MEDIUM FOR PERFUSION AND PRESERVATION OF ORGANS.
US4920044A (en) *	1988-11-08	1990-04-24	The Cleveland Clinic Foundation	Intracellular flush solution for preserving organs
US4938961A (en) *	1989-04-28	1990-07-03	Geoffrey Collins	Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia

1991
- 1991-11-05 CH CH3224/91A patent/CH683485A5/en not_active IP Right Cessation
- 1991-11-11 IT ITMI912991A patent/IT1251995B/en active IP Right Grant
- 1991-11-18 AT AT0228791A patent/AT399440B/en not_active IP Right Cessation
- 1991-11-18 GB GB9124488A patent/GB2249937B/en not_active Expired - Lifetime
- 1991-11-18 ES ES09102549A patent/ES2050580B1/en not_active Expired - Fee Related
- 1991-11-19 CA CA002055827A patent/CA2055827C/en not_active Expired - Lifetime
- 1991-11-19 BE BE9101067A patent/BE1006834A3/en not_active IP Right Cessation
- 1991-11-19 DE DE4138040A patent/DE4138040A1/en not_active Withdrawn

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4473552A (en) *	1981-03-16	1984-09-25	Jost Leonora I	Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells
US4423600A (en) *	1982-12-10	1984-01-03	Mckenna Joan J	Method for preservation of living organic tissue by freezing

Also Published As

Publication number	Publication date
CH683485A5 (en)	1994-03-31
AT399440B (en)	1995-05-26
ES2050580B1 (en)	1994-12-16
GB2249937A (en)	1992-05-27
ITMI912991A0 (en)	1991-11-11
ES2050580A1 (en)	1994-05-16
BE1006834A3 (en)	1995-01-03
CA2055827C (en)	1999-06-15
IT1251995B (en)	1995-05-27
CA2055827A1 (en)	1992-05-21
ITMI912991A1 (en)	1993-05-11
ATA228791A (en)	1994-10-15
GB9124488D0 (en)	1992-01-08
DE4138040A1 (en)	1992-05-21

Publication	Publication Date	Title
ZA889683B (en)	1989-09-27	Perfusate for the preservation of organs
AU5558190A (en)	1990-11-29	Organ preservation solution and method
GB9011756D0 (en)	1990-07-18	Cell preservation system
NO943473D0 (en)	1994-09-19	"Freezer" piece with the skin's pH and process for its preparation
HUT44415A (en)	1988-03-28	Fungicides comprising alpha-aryl-alpha-phenyl-ethyl-1h 1,2,4 triazole-1-propanenitrile derivatives as active substance and process for preparing the active substance
GB2270614B (en)	1996-03-20	Solution for the perfusion, preservation and reperfusion of organs
GB2249937B (en)	1994-02-16	Solutions for the perfusion, preservation and reperfusion of organs
HUT44414A (en)	1988-03-28	Pesticide comprising 1,2,3,6 tetrahydro-5-nitropyrimidine derivatives as active substance and process for preparing the active substance
NO893142D0 (en)	1989-08-03	PROCEDURE FOR THE PRESERVATION OF Ophthalmological SOLUTIONS AND COMPOSITIONS FOR THE PURPOSE.
HU00207A9 (en)	1995-09-28	Sulfonanilide derivatives and medicine
AU7542191A (en)	1992-05-20	Blood cryopreservation container
IL97162A0 (en)	1992-05-25	Blood cryopreservation bag
EP0559895A4 (en)	1994-08-17	Albumin preparation and preservation thereof
HU910126D0 (en)	1991-08-28	Active agent combination with fungicide effect
HUT36088A (en)	1985-08-28	Fungicide, insecticide and acaricide compositions formaenide derivatives and process for preparing the active substance
HU910127D0 (en)	1991-08-28	Active agent combination with fungicide effect
GB9115199D0 (en)	1991-08-28	Amplifying arrangements
ZA919297B (en)	1992-08-26	Stabilized hexahydro-pyrimidinamine compounds in aqueous solution and methods for preparing same
FI911989L (en)	1991-10-26	BLANKET AND PROCEDURE.
HU910408D0 (en)	1991-08-28	Microbicide perparatives containing pyrimidinyl-phenyl-hydroxyl-amine derivatives as active substance and process for producing the active substance
IL96906A0 (en)	1992-03-29	Cryopreservation process for the direct transer of embryos
GB9021566D0 (en)	1990-11-21	Fresh/'preserved'fresh/'imitation',flowers
FR2679107B1 (en)	1993-11-05	ORGANIC PERFUSION, PRESERVATION AND REPERFUSION SOLUTIONS.
GB8907235D0 (en)	1989-05-10	Preservation of forage
GB8830197D0 (en)	1989-02-22	Tissue preservation medium

Legal Events

Date	Code	Title	Description
1999-10-27	732E	Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
2011-12-07	PE20	Patent expired after termination of 20 years	Expiry date: 20111117