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GB2200642A - Small molecular weight antigen of plasmodium falciparum - Google Patents

Small molecular weight antigen of plasmodium falciparum

Info

Publication number
GB2200642A
GB2200642A GB08806391A GB8806391A GB2200642A GB 2200642 A GB2200642 A GB 2200642A GB 08806391 A GB08806391 A GB 08806391A GB 8806391 A GB8806391 A GB 8806391A GB 2200642 A GB2200642 A GB 2200642A
Authority
GB
United Kingdom
Prior art keywords
molecular weight
antigen
small molecular
plasmodium falciparum
falciparum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB08806391A
Other versions
GB2200642B (en
GB8806391D0 (en
Inventor
Ursula Anna Kate Kara
Deborah Joan Stenzel
Gillian Robin Bushell
Hendrik Mario Geysen
Allan James Saul
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Saramane Pty Ltd
Original Assignee
Saramane Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saramane Pty Ltd filed Critical Saramane Pty Ltd
Publication of GB8806391D0 publication Critical patent/GB8806391D0/en
Publication of GB2200642A publication Critical patent/GB2200642A/en
Application granted granted Critical
Publication of GB2200642B publication Critical patent/GB2200642B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C07K16/205—Plasmodium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A small molecular weight antigen of the asexual blood stages of Plasmodium falciparum which is characterized by: (i) having an apparent molecular weight in the range of approximately 15 kD to 19 kD; (ii) not showing significant glycosylation by galactose or glucosamine labelling, but being acylated by myristic acid; (iii) being associated with the parasitophorous vacuole membrane and with inclusions and vesicles residing within the cytoplasm of the erythrocyte host cell; and (iv) being recognised by monoclonal antibodies against the asexual blood stages of P. falciparum which inhibit parasite growth in vitro; or an antigenic fragment thereof. A monoclonal antibody specific for this antigen, and a hybrid cell line which produces this antibody is also disclosed.
GB8806391A 1986-07-17 1987-07-17 Small molecular weight antigen of plasmodium falciparum Expired - Fee Related GB2200642B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPH698386 1986-07-17
AUPI104687 1987-03-24
PCT/AU1987/000226 WO1988000597A1 (en) 1986-07-17 1987-07-17 Small molecular weight antigen of plasmodium falciparum

Publications (3)

Publication Number Publication Date
GB8806391D0 GB8806391D0 (en) 1988-05-25
GB2200642A true GB2200642A (en) 1988-08-10
GB2200642B GB2200642B (en) 1991-01-09

Family

ID=25643128

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8806391A Expired - Fee Related GB2200642B (en) 1986-07-17 1987-07-17 Small molecular weight antigen of plasmodium falciparum

Country Status (8)

Country Link
EP (1) EP0273971A4 (en)
JP (1) JPH01500827A (en)
KR (1) KR880701733A (en)
DK (1) DK146288A (en)
GB (1) GB2200642B (en)
IL (1) IL83231A0 (en)
NZ (1) NZ221115A (en)
WO (1) WO1988000597A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5231168A (en) * 1988-09-16 1993-07-27 Statens Seruminstitut Malaria antigen
WO1990015621A1 (en) * 1989-06-19 1990-12-27 Statens Seruminstitut A malaria vaccine
SE9002684D0 (en) * 1990-08-17 1990-08-17 Malvac Foundation C O Peter Pe NEW PEPTIDES AND THEIR USE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8404378D0 (en) * 1984-02-20 1984-03-28 Biogen Nv Dna sequence recombinant dna molecules
FR2589062B1 (en) * 1985-10-28 1990-05-04 Inst Nat Sante Rech Med ANTIGENS OBTAINED FROM THE INTRAERYTHROCYTA PHASE OF PLASMODIUM FALCIPARUM, THEIR PURIFICATION, THEIR DOSAGE AS WELL AS THAT OF THEIR ANTIBODIES, AND MALARIA VACCINES CONTAINING THEM
AU606042B2 (en) * 1985-12-24 1991-01-31 Saramane Pty Ltd Asexual blood stage antigens of plasmodium falciparum

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AU A 39959/85 *
AU A 66877/86 *
JOURNAL OF IMMUNOLOGICAL METHODS, VOLUME 86, 1986 PAGES 257 TO 264 *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (USA), VOLUME 82, AUGUST 1985, PAGES 5121 TO 5125 *

Also Published As

Publication number Publication date
EP0273971A4 (en) 1989-09-19
KR880701733A (en) 1988-11-04
NZ221115A (en) 1991-04-26
IL83231A0 (en) 1987-12-31
DK146288D0 (en) 1988-03-17
WO1988000597A1 (en) 1988-01-28
DK146288A (en) 1988-05-17
JPH01500827A (en) 1989-03-23
EP0273971A1 (en) 1988-07-13
GB2200642B (en) 1991-01-09
GB8806391D0 (en) 1988-05-25

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee