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GB2198130B - Novel prostacyclines - Google Patents

Novel prostacyclines

Info

Publication number
GB2198130B
GB2198130B GB8727991A GB8727991A GB2198130B GB 2198130 B GB2198130 B GB 2198130B GB 8727991 A GB8727991 A GB 8727991A GB 8727991 A GB8727991 A GB 8727991A GB 2198130 B GB2198130 B GB 2198130B
Authority
GB
United Kingdom
Prior art keywords
prostacyclines
novel
novel prostacyclines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8727991A
Other versions
GB2198130A (en
GB8727991D0 (en
Inventor
George William Holland
Hans Maag
Perry Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HOFFMANN LA ROCHE
F Hoffmann La Roche AG
Original Assignee
HOFFMANN LA ROCHE
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HOFFMANN LA ROCHE, F Hoffmann La Roche AG filed Critical HOFFMANN LA ROCHE
Publication of GB8727991D0 publication Critical patent/GB8727991D0/en
Publication of GB2198130A publication Critical patent/GB2198130A/en
Application granted granted Critical
Publication of GB2198130B publication Critical patent/GB2198130B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
GB8727991A 1986-12-01 1987-11-30 Novel prostacyclines Expired - Lifetime GB2198130B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93652286A 1986-12-01 1986-12-01

Publications (3)

Publication Number Publication Date
GB8727991D0 GB8727991D0 (en) 1988-01-06
GB2198130A GB2198130A (en) 1988-06-08
GB2198130B true GB2198130B (en) 1990-08-08

Family

ID=25468757

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8727991A Expired - Lifetime GB2198130B (en) 1986-12-01 1987-11-30 Novel prostacyclines

Country Status (14)

Country Link
JP (1) JPS63145275A (en)
AT (1) AT391697B (en)
AU (1) AU597128B2 (en)
BE (1) BE1001271A5 (en)
CH (1) CH674363A5 (en)
DE (1) DE3740595A1 (en)
DK (1) DK627787A (en)
FR (1) FR2607501A1 (en)
GB (1) GB2198130B (en)
IT (1) IT1223390B (en)
NL (1) NL8702855A (en)
NZ (1) NZ222723A (en)
SE (1) SE8704770L (en)
ZA (1) ZA878947B (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054795A2 (en) * 1980-12-09 1982-06-30 Teijin Limited Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof
GB2094310A (en) * 1981-03-11 1982-09-15 Hoffmann La Roche Novel fluoro-prostacyclins
EP0148953A1 (en) * 1983-06-10 1985-07-24 Asahi Glass Company Ltd. 7-fluoroprostaglandins and process for their preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565827A (en) * 1980-10-27 1986-01-21 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 7-Substituted PGI2 -derivatives and pharmaceutical compositions containing them
US4558142A (en) * 1981-03-11 1985-12-10 Hoffmann-La Roche Inc. 7-Fluoro-prostacyclin analogs
JPS5867682A (en) * 1981-10-16 1983-04-22 Teijin Ltd Preparation of fluoro-pgi2
JPS58150583A (en) * 1982-03-04 1983-09-07 Teijin Ltd Novel halogenated prostacyclins, their preparations, and pharmaceutical compositions comprising them as active ingredients
US4634782A (en) * 1985-06-24 1987-01-06 Hoffmann-La Roche Inc. 7-fluoro-dihydro PGI compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054795A2 (en) * 1980-12-09 1982-06-30 Teijin Limited Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof
GB2094310A (en) * 1981-03-11 1982-09-15 Hoffmann La Roche Novel fluoro-prostacyclins
EP0148953A1 (en) * 1983-06-10 1985-07-24 Asahi Glass Company Ltd. 7-fluoroprostaglandins and process for their preparation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Chem. Pharm. Bull. 32 (3)1248-51 (19 *
JP 58/150583 *
JP 58/67682 *
Tetrahedron 39 (22)3807-19 (1983) *
Tetrahedron 42 (24)6735-46 (1986) *

Also Published As

Publication number Publication date
AU597128B2 (en) 1990-05-24
ZA878947B (en) 1988-06-01
DE3740595A1 (en) 1988-06-16
SE8704770L (en) 1988-06-02
NL8702855A (en) 1988-07-01
DK627787A (en) 1988-06-02
IT8722814A0 (en) 1987-11-30
SE8704770D0 (en) 1987-11-30
GB2198130A (en) 1988-06-08
CH674363A5 (en) 1990-05-31
AT391697B (en) 1990-11-12
IT1223390B (en) 1990-09-19
NZ222723A (en) 1990-11-27
BE1001271A5 (en) 1989-09-12
DK627787D0 (en) 1987-11-30
FR2607501A1 (en) 1988-06-03
JPS63145275A (en) 1988-06-17
ATA313887A (en) 1990-05-15
GB8727991D0 (en) 1988-01-06
AU8190787A (en) 1988-06-02

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee