GB2117534A - Papain containing tablet for cleaning contact lenses - Google Patents
Papain containing tablet for cleaning contact lenses Download PDFInfo
- Publication number
- GB2117534A GB2117534A GB08308887A GB8308887A GB2117534A GB 2117534 A GB2117534 A GB 2117534A GB 08308887 A GB08308887 A GB 08308887A GB 8308887 A GB8308887 A GB 8308887A GB 2117534 A GB2117534 A GB 2117534A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tablet
- sodium
- papain
- potassium
- ethylenediaminetetraacetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004365 Protease Substances 0.000 title claims abstract description 25
- 108090000526 Papain Proteins 0.000 title claims abstract description 24
- 229940055729 papain Drugs 0.000 title claims abstract description 24
- 235000019834 papain Nutrition 0.000 title claims abstract description 24
- 238000004140 cleaning Methods 0.000 title abstract description 6
- 239000003826 tablet Substances 0.000 claims abstract description 86
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 31
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims abstract description 19
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 16
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 16
- 239000001103 potassium chloride Substances 0.000 claims abstract description 15
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 15
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 11
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 11
- 239000000126 substance Substances 0.000 claims abstract description 9
- 150000001875 compounds Chemical class 0.000 claims abstract description 8
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000018417 cysteine Nutrition 0.000 claims abstract description 8
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 7
- 230000003213 activating effect Effects 0.000 claims abstract description 7
- 235000015497 potassium bicarbonate Nutrition 0.000 claims abstract description 7
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims abstract description 7
- 239000011736 potassium bicarbonate Substances 0.000 claims abstract description 7
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims abstract description 7
- 239000007864 aqueous solution Substances 0.000 claims abstract description 5
- 239000004554 water soluble tablet Substances 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 229910052708 sodium Inorganic materials 0.000 claims description 9
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 150000002500 ions Chemical class 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 abstract description 13
- -1 cysteine Chemical class 0.000 abstract description 2
- 150000003839 salts Chemical class 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 21
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 14
- 239000012153 distilled water Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 9
- 229920001223 polyethylene glycol Polymers 0.000 description 9
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- 235000010234 sodium benzoate Nutrition 0.000 description 7
- 239000004299 sodium benzoate Substances 0.000 description 7
- 239000002202 Polyethylene glycol Substances 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 235000002639 sodium chloride Nutrition 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 235000013878 L-cysteine Nutrition 0.000 description 4
- 239000004201 L-cysteine Substances 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000012458 free base Substances 0.000 description 4
- 239000000644 isotonic solution Substances 0.000 description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 description 4
- 229940001593 sodium carbonate Drugs 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 235000010235 potassium benzoate Nutrition 0.000 description 3
- 239000004300 potassium benzoate Substances 0.000 description 3
- 229940103091 potassium benzoate Drugs 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 2
- 150000008040 ionic compounds Chemical class 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 239000007944 soluble tablet Substances 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical class NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229960004716 idoxuridine Drugs 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000004296 sodium metabisulphite Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0047—Detergents in the form of bars or tablets
- C11D17/0065—Solid detergents containing builders
- C11D17/0073—Tablets
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38609—Protease or amylase in solid compositions only
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Eyeglasses (AREA)
- Detergent Compositions (AREA)
Abstract
A water soluble tablet comprises 4 to 25mg of papain and 15 to 50mg of potassium chloride as tablet diluent, for use in cleaning soft contact lenses. The tablet may contain 4 to 25mg of a thiolic activating compound e.g. cysteine, 1 to 25mg of a chelating substance e.g. ethylenediaminetetraacetic acid or salt thereof, and sodium or potassium bicarbonate or carbonate to render the pH of an aqueous solution of the tablet 4 to 9.
Description
SPECIFICATION
Soluble tablet and use thereof
The present invention relates to a soluble tablet containing papain and to the use of said tablet in forming a solution which may be employed in removing proteinaceous deposits from contact lenses.
Papain has long been known to be suitable for removing proteinaceous deposits from articles that come into contact with humans. One class of articles that require to be treated to remove proteinaceous deposits is contact lenses. British Patent No. 141 9750 describes how an isotonic solution of protease enzymes may be employed to clean contact lenses and describes a favoured tablet which, in dissolution in distilled water, can be used to prepare an isotonic solution of papain. German Offenlegungschrift P2854278 describes how non-ionic wetting agents may be used to enhance the effectiveness of isotonic solutions of proteases.It has been generally believed that in order to treat soft (hydrophilic) contact lenses the enzyme solution employed should be isotonic and to this end tablets such as "Hydrocare" (Trade Mark of Allergan
Pharmaceuticals) contain sufficient sodium chloride to render the cleaning solution isotonic.
Unfortunately known tablets have tended to be somewhat slow to dissolve and it would be a considerable advantage if a more rapidly dissolving tablet could be found.
It has now been discovered that a tablet can be prepared that dissolves to yield a solution capable of removing proteinaceous deposits from soft contact lenses. The new tablet does not dissolve to produce an isotonic solution but that is not now deemed to be necessary despite the numerous indications in the prior art that cleaning solutions should be isotonic.
The present invention provides a tablet which comprises 4 to 25mg of papain and 1 5 to 260mg of a tablet diluent.
By tablet diluent is meant an inert substance which is added to the active ingredient to increase the bulk in order to make the tablet a practicai size for compression. Our copending
British Application No. 8129621, now published as UK Patent Application GB 2088581A discloses a tablet comprising papain and lactose. Excellent and effective though the tablets described therein are it has now been found that by replacing a substantial part of or all of the lactose by an ionic compound as tablet diluent, tablets having an improved ease of manufacture, better binding properties, better colour stability on storage and an improved rate of dissolution may be prepared. Suitable diluents which generate ions when dissolved in water include the sodium and potassium salts of hydrochloric or hydrobromic acid. Preferred ionic diluents are sodium and potassium chlorides.A particularly preferred ionic diluent is potassium chloride.
Most aptly the tablet will contain no lactose.
When the diluent is an ionic compound the tablet will contain from 1 5 to 50mg of the diluent and preferably 20 to 40mg of the ionic diluent in each tablet. Such tablets when dissolved in 10ml of water will yield a solution which is not isotonic.
From the foregoing it is clear that the present invention comprises a water soluble tablet which comprises 4 to 25mg of papain and 1 5 to 50mg of potassium chloride.
The tablet of this invention may also contain a thiolic activating such as cystiene. Thus in an alternative formulation the present invention provides a tablet which comprises 4 to 25mg of papain, 4 to 25mg of a thiolic activating compound and 1 5 to 50mg of potassium chloride as tablet diluent.
Suitable thiolic activating compounds include cysteine and acid addition salts thereof, sodium bisulphite, sodium metabisulphite and dithiothreitol. Most aptly the thiolic activating compound is cysteine.
Suitable tablet diluents are hereinbefore described.
It has however, proved desirable to include within the tablet a substance capable of chelating multivalent ions such as calcium. The agent of choice for this purpose is ethylenediaminetetraacetic acid. This compound may be employed as the acid or as a sodium or potassium salt such as disodium ethylenediaminetetraacetic acid or the like. However it has been found that significant advantages in ease of tablet formation occur if the parent ethylenediaminetetraacetic acid is employed. This is a departure from the conventional method of using the compound as the disodium salt.
Normally the tablet of this invention will contain from 1 to 25mg of ethylenediaminetetraacetic acid or a sodium or potassium salt thereof which, as said hereinbefore it is preferred to employ the parent acid.
The tablet of this invention will also aptly contain a sodium or potassium bicarbonate or carbonate to render the pH of the cleansing solution acceptable, for example from 4 to 9 and more suitably from 5 to 8. In general this requires that the tablet of this invention contains from 1 to 25mgs of sodium or potassium bicarbonate or carbonate. Use of bicarbonate or carbonates for this purpose is advantageous as it can lead to more rapid dissolution of the tablet due to small amounts of effervescence. However the combination of the components of the tablet does not have buffering capacity when dissolved in water.
If desired the tablet of this invention may contain small amounts of tabletting aids, for example sodium or potassium benzoate. Most aptly such aids are present in the range of 2 to 20mgs per tablet.
If desired the tablet of this invention may also contain a tablet lubricant in the form of a water soluble polymer. Suitable polymers include the water soluble polyalkylene glycols, preferably a polyethylene glycol. Suitable polyethylene glycols are those known as Carbowaxes (Registered trade mark of Union Carbide Co.) having a molecular weight of approximately 4,000 to 8,000.
A preferred polyethylene glycol is one having a molecular weight of 8,000, known as Carbowax
PEG 8000. Suitably the tablet will contain from 1 to 1 Omg and preferably 2 to 5mg of the tablet lubricant.
Most aptly the tablet of this invention may contain 5 to 12mg of papain.
Most suitably the tablet of this invention will comprise 5 to 12mg of papain, 1 5 to 50mg of potassium chloride, 5 to 15mg of ethylenediaminetetraacetic acid, 8 to 18mg of sodium or potassium bicarbonate or carbonate and 5 to 1 Omg of sodium or potassium benzoate.
Preferred tablets of this invention will consist essentially of 6 to 20mg of papain, 20 to 35mg potassium chloride, 5 to 1 Omg of ethylenediaminetetraacetic acid, 1 to 15mg of sodium bicarbonate and 5 to 1 Omg of sodium benzoate.
Most aptly the tablet of this invention may also contain 5 to 12mg of cysteine and preferably will contain 6 to 1 Omg of cysteine.
Most suitably in an alternative formulation the tablet of this invention will comprise 5 to 12mg of papain, 5 to 12mg cysteine, 1 5 to 50mg of a tablet diluent, 5 to 25mg of ethylenediaminetetraacetic acid, 8 to 18mg of sodium or potassium bicarbonate or carbonate and 5 to 1 Omg of sodium or potassium benzoate.
Preferred alternative formulations of the tablets of this invention will consist essentially of 6 to 20mg of papain, 6 to 1 Omg of cysteine, 20 to 35mg of potassium chloride, 5 to 1 Omg of ethylenediaminetetraacetic acid, 10 to 15mg of sodium bicarbonate and 5 to 1 Omg of sodium benzoate.
A particularly preferred alternative formulation will comprise 6 to 20mg of papain, 6 to 1 Omg of L-cysteine, 20 to 35mg of potassium chloride, 5 to 20mg of ethylenediaminetetraacetic acid, 5 to 1 Omg of sodium carbonate and 2 to 5mg of polyethylene glycol (molecular weight 4000).
The papain employed in this invention is suitably Prolase 300 (trade mark).
If desired other small amounts of conventional excipients may be included with the tablet formulation. Thus for example small amounts of sodium chloride (for example 2-5%) may be employed as long as it does not substantially effect the rate of dissolution of the tablet. Similarly a wetting agent which is aptly a solid non-ionic surface active agent may be included if desired, for example a polyoxyethylene-polyoxypropylene block copolymer such as Pluronic F68 (trade mark). or polyoxyethylene stearate such as Myrj 53 (trade mark). The tablets of this invention may be dissolved in distilled water to yield a cleansing solution suitable for soft contact lenses.
The tablet as herein before described will in use be dissolved in water, preferably distilled water, to give a solution which is significantly less than isotonic. In general tablets having a weight of from 50mg to 180mg will most aptly be dissolved in 1 Oml or other similar volume of water to give a solution which is significantly less than isotonic and is suitable for removing proteinaceous deposits.
In an important aspect, this invention provides a method of removing proteinaceous deposits from a contact lens which method comprises contacting the said lens with an aqueous solution, formed by dissolving in water a tablet of this invention for sufficient time to clean the lens.
Suitably one tablet may be used per lens. In general the tablet will be dissolved in 1 Oml of distilled water. In use the solution will be made up in a suitable container, for example a glass bottle closed by a plastic cap. The lens may be placed in the solution and the container closed.
Alternatively the lenses may be placed in a perforated lens holder so that the lenses from the right and left eye are readily identified and the lens holder placed in a solution prepared from a tablet and distilled water such that both lenses are covered by the enzyme solution.
In general the lens will be in contact with the solution of the enzyme for from 1 to 24 hours, suitably from 2 to 1 2 hours and preferably from 4 to 8 hours. It is often convenient to clean the lens by keeping it at room temperature for this period, that is approximately 20deg.C. A shorter cleaning time may be envisaged if the temperature is maintained above 20 deg.C. but below the inactivation temperature of the enzyme, for example, the temperature may be advantageously maintained at 40deg.C.
After cleaning the lens will be rinsed with distilled water and sterilised before re-insertion in the eye in a conventional manner.
The following Examples illustrate the invention:
Example 1
A tablet of the following composition is prepared on a hand punch to give tablets of a hardness 3.5kg.
(Monsanto tablet hardness tester).
Papain 7.5mg
Ethylenediaminetetraacetic acid 6.5mug Sodium bicarbonate 13.0mug Sodium benzoate 5.0mg Potassium chloride 25.0mg The tablet which is 3/16" in diameter has a good appearance and dissolved quickly on shaking in 10ml of distilled water to yield a solution capable of removing proteinaceous deposits from soft contact lenses.
Example 2
A tablet of the following composition was prepared on a hand punch to give tablets of hardness 3.5kg (Monsanto hardness tester).
Papain 7.5mg L-cysteine (free base) 8. Omg Ethylenediaminetetraacetic acid 8.Omg
Sodium carbonate 5.0mg Potassium chloride 30.0mg Polyethylene glycol (M.W. 4000) 3.0mg The tablet had a good appearance and dissolved quickly on shaking in 1 Oml of distilled water to yield a solution capable of removing proteinaceous deposits from soft lenses.
Example 3
A tablet of the following composition was prepared in a hand punch to give tablets of hardness 3.5kg (Monsanto hardness tester).
Papain 7.5mg
L-cysteine (free base) 8.0mg Sodium bicarbonate 20.0mg Sodium benzoate 5.0mg Ethylenediaminetetraacetic acid 8.0mg Sodium chloride 20.0mg The tablet had a good appearance and dissolved on shaking in 1 Oml of distilled water to yield a solution capable of removing proteinaceous deposits from soft lenses.
Example 4
A tablet of the following composition is prepared on a hand punch to give tablets of hardness 3.5kg (Monsanto hardness tester).
Papain 7.5mg
L-cysteine (free base) 8.0mg Ethylenediaminetetraacetic acid 8.Omg
Sodium carbonate 5.0mg
Potassium chloride 30.0mg Polyethylene glycol (M.W. 6000) 3.0mg The tablet has a good appearance and will dissolve quickly on shaking in 1 Oml of distilled water to yield a solution capable of removing proteinaceous deposits from soft lenses.
Example 5
A tablet of the following composition was prepared in a hand punch to give tablets of a hardness 3.5kg (Monsanto hardness tablet tester).
Papain 13.5mg L-cysteine (free base) 8.0mg
Ethylenediaminetetraacetic acid 8.Omg
Sodium carbonate 5.0mg Potassium chloride 30.0mg Polyethylene glycol (M.W. 6000) 3.0mg The tablet has a good appearance and will dissolve quickly on shaking in 1 Oml of distilled water to yield a solution capable of removing proteinaceous deposits from soft lenses. The resultant solution is not isotonic.
Claims (14)
1. A water soluble tablet which comprises 4 to 25mg of papain and 5 to 50mg of potassium chloride.
2. A tablet as claimed in claim 1 which comprises 4 to 25mg of papain and 20 to 40mg of potassium chloride.
3. A tablet as claimed in claim 2 which also includes 1 to 25mg of a substance capable of chelating multivalent ions.
4. A tablet as claimed in claim 3 in which the chelating substance is ethylenediaminetetraacetic acid or a sodium or potassium salt thereof.
5. A tablet as claimed in either of claims 3 to 4 in which the chelating substance is ethylenediaminetetraacetic acid.
6. A tablet as claimed in any of claims 2 to 5 which also contains sodium or potassium bicarbonate or carbonate sufficient to render the pH of an aqueous solution of the tablet from 4 to 9.
7. A tablet as claimed in any of claims 2 to 6 which also contains 1 to 20mg of a tabletting aid.
8. A water soluble tablet which comprises 4 to 25mg of papain, 4 to 25mg of a thiolic activating compound and 1 5 to 50mg of potassium chloride.
9. A tablet as claimed in claim 8 in which the thiolic activating compound is cysteine.
10. A tablet as claimed in either of claims 8 or 9 which also contains 1 to 25mg of a substance capable of chelating multivalent ions.
11. A tablet as claimed in claim 10 in which the chelating substance is ethylenediaminetetraacetic acid or a sodium or potassium salt thereof.
1 2. A tablet as claimed in either of claims 10 or 11 in which the chelating substance is ethylenediam i netetraacetic acid.
1 3. A tablet as claimed in any of claims 8 to 1 2 which also contains sodium or potassium bicarbonate or carbonate sufficient to render the pH of an aqueous solution of the tablet from 4 to 9.
14. A tablet as claimed in any of claims 8 to 1 3 which also contains from 1 to 20mg of a tabletting aid.
1 5. A method for removing proteinaceous deposits from a contact lens which method comprises contacting said lens with an aqueous solution formed by dissolving in water a tablet as claimed in any of claims 1 to 14 for sufficient time to clean the lens.
1 6. A method as claimed in claim 1 5 in which the contact lens is a soft contact lens.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08308887A GB2117534B (en) | 1982-03-31 | 1983-03-30 | Papain containing tablet for cleaning contact lenses |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8209471 | 1982-03-31 | ||
| GB08308887A GB2117534B (en) | 1982-03-31 | 1983-03-30 | Papain containing tablet for cleaning contact lenses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2117534A true GB2117534A (en) | 1983-10-12 |
| GB2117534B GB2117534B (en) | 1986-02-19 |
Family
ID=26282434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB08308887A Expired GB2117534B (en) | 1982-03-31 | 1983-03-30 | Papain containing tablet for cleaning contact lenses |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2117534B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0219220A1 (en) * | 1985-09-09 | 1987-04-22 | Allergan, Inc | Method and composition for the simultaneous cleaning and disinfecting of contact lenses |
| EP0252974A4 (en) * | 1986-01-06 | 1988-05-03 | Allergan Inc | Enhancement of enzymatic activity in cleaning contact lenses by the use of hypotonic solutions. |
| EP0278224A1 (en) * | 1987-01-16 | 1988-08-17 | Henkel Kommanditgesellschaft auf Aktien | Process for the production of disinfecting working contact lenses - cleaning agents tablets |
| GB2252421A (en) * | 1990-12-31 | 1992-08-05 | Tchelva Ramanathan | Cleaning soft contact lenses |
| WO1992021049A1 (en) * | 1991-05-10 | 1992-11-26 | Allergan, Inc. | Methods and compositions for inhibiting deposit formation on contact lenses |
| WO1995000621A1 (en) * | 1993-06-17 | 1995-01-05 | Allergan, Inc. | Enzyme compositions and methods for contact lens cleaning |
| WO1995016017A1 (en) * | 1993-12-06 | 1995-06-15 | Allergan | Sugar-based cleansing composition for contact lenses |
| US5783532A (en) * | 1993-06-17 | 1998-07-21 | Allergan | Enzyme compositions and methods for contact lens cleaning |
| WO2001059058A1 (en) * | 2000-02-09 | 2001-08-16 | Reckitt Benckiser N.V. | Detergent composition in tablet form |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1265250A (en) * | 1969-05-29 | 1972-03-01 | ||
| GB1419750A (en) * | 1973-04-20 | 1975-12-31 | Allergan Pharma | Method and compostiion of removing proteinaceous deposits from contact lenses |
-
1983
- 1983-03-30 GB GB08308887A patent/GB2117534B/en not_active Expired
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1265250A (en) * | 1969-05-29 | 1972-03-01 | ||
| GB1419750A (en) * | 1973-04-20 | 1975-12-31 | Allergan Pharma | Method and compostiion of removing proteinaceous deposits from contact lenses |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0219220A1 (en) * | 1985-09-09 | 1987-04-22 | Allergan, Inc | Method and composition for the simultaneous cleaning and disinfecting of contact lenses |
| EP0252974A4 (en) * | 1986-01-06 | 1988-05-03 | Allergan Inc | Enhancement of enzymatic activity in cleaning contact lenses by the use of hypotonic solutions. |
| EP0278224A1 (en) * | 1987-01-16 | 1988-08-17 | Henkel Kommanditgesellschaft auf Aktien | Process for the production of disinfecting working contact lenses - cleaning agents tablets |
| GB2252421A (en) * | 1990-12-31 | 1992-08-05 | Tchelva Ramanathan | Cleaning soft contact lenses |
| WO1992021049A1 (en) * | 1991-05-10 | 1992-11-26 | Allergan, Inc. | Methods and compositions for inhibiting deposit formation on contact lenses |
| WO1995000621A1 (en) * | 1993-06-17 | 1995-01-05 | Allergan, Inc. | Enzyme compositions and methods for contact lens cleaning |
| US5630884A (en) * | 1993-06-17 | 1997-05-20 | Allergan | Methods for contact lens cleaning |
| US5746838A (en) * | 1993-06-17 | 1998-05-05 | Allergan | Enzyme compositions and methods for contact lens cleaning |
| US5783532A (en) * | 1993-06-17 | 1998-07-21 | Allergan | Enzyme compositions and methods for contact lens cleaning |
| US6165954A (en) * | 1993-06-17 | 2000-12-26 | Allergan, Inc. | Enzyme compositions and methods for contact lens cleaning |
| WO1995016017A1 (en) * | 1993-12-06 | 1995-06-15 | Allergan | Sugar-based cleansing composition for contact lenses |
| WO2001059058A1 (en) * | 2000-02-09 | 2001-08-16 | Reckitt Benckiser N.V. | Detergent composition in tablet form |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2117534B (en) | 1986-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20020330 |