GB2062459A - Excipient for pharmaceutical compositions - Google Patents
Excipient for pharmaceutical compositions Download PDFInfo
- Publication number
- GB2062459A GB2062459A GB7938519A GB7938519A GB2062459A GB 2062459 A GB2062459 A GB 2062459A GB 7938519 A GB7938519 A GB 7938519A GB 7938519 A GB7938519 A GB 7938519A GB 2062459 A GB2062459 A GB 2062459A
- Authority
- GB
- United Kingdom
- Prior art keywords
- excipient
- sago
- compositions
- starch
- flour
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 16
- 239000000546 pharmaceutical excipient Substances 0.000 title claims description 17
- 235000013312 flour Nutrition 0.000 claims abstract description 18
- 229920002472 Starch Polymers 0.000 claims abstract description 13
- 235000019698 starch Nutrition 0.000 claims abstract description 13
- 239000002775 capsule Substances 0.000 claims abstract description 11
- 239000008107 starch Substances 0.000 claims abstract description 11
- 239000000945 filler Substances 0.000 claims abstract description 5
- 239000007884 disintegrant Substances 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 18
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 6
- 206010020751 Hypersensitivity Diseases 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 239000012178 vegetable wax Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims description 2
- 235000007164 Oryza sativa Nutrition 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- 244000061456 Solanum tuberosum Species 0.000 claims description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 241000209140 Triticum Species 0.000 claims description 2
- 235000021307 Triticum Nutrition 0.000 claims description 2
- 229930003451 Vitamin B1 Natural products 0.000 claims description 2
- 240000008042 Zea mays Species 0.000 claims description 2
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 claims description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000001175 calcium sulphate Substances 0.000 claims description 2
- 235000011132 calcium sulphate Nutrition 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 230000000774 hypoallergenic effect Effects 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 235000009973 maize Nutrition 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 235000009566 rice Nutrition 0.000 claims description 2
- 239000000377 silicon dioxide Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 229960003495 thiamine Drugs 0.000 claims description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 2
- 239000011691 vitamin B1 Substances 0.000 claims description 2
- 235000010374 vitamin B1 Nutrition 0.000 claims description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
A filler disintegrant for pharmaceutical compositions e.g. tablets, capsules, comprises sago flour and/or a modified sago flour or starch.
Description
SPECIFICATION
Excipient for pharmaceutical compositions
This invention relates to pharmaceutical compositions, and in particular to an excipienttherefor.
Conventional excipients for pharmaceutical compositions in tablet or capsule form include potato, maize, wheat and rice starches and carbohydrates such as lactose (milk sugar), sucrose and glucose.
These known excipients have the problem that they can cause allergic reactions to some patients.
The present invention provides a pharmaceutical composition comprising a pharmaceutically active ingredient and, as an excipient, sago flour and/or a modified sago flour or starch. Such a composition is particularly applicable to pharmaceutical preparations in tablet or capsule form.
The excipient used in the compositions of the invention imparts a significant hypoallergenic, thus significantly reducing the risk of allergic reactions in the patient.
The sago is preferably milled to a particle size of 20 to 65 microns. There are two preferred ways of making up compositions in accordance with the invention, as follows:
1. A paste of 20% starch in boiling water is prepared, and used as a granulating medium for tablets or capsules.
2. The starch is used as a filler and disintegrant in tablets, the filler comprising 10 to 25 wt.% of the composition.
Three preferred compositions in accordance with the invention are as follows:
COMPOSITION 1: Vitamin B1 100 mg
Calcium Sulphate 100 mg
Sago Flour 50 mg
Vegetable Wax 10 mg
COMPOSITION2:
Acetylsalicylic Acid 300 mg
Sago Flour 30 mg
Vegetable Wax 15 mg
COMPOSITION3:
Dried Yeast 300 mg
Powdered Silica 10 mg
Powdered Sago 15 mg
CLAIMS
1. A pharmaceutical composition comprising a pharmaceutically active ingredient, as an excipient, sago flour and/or a modified sago flour or starch.
2. Acomposition according to claim 1 wherein the excipient has a particle size of 20 to 65 microns.
3. A pharmaceutical composition substantially as herein described with reference to any one of Compositions 1 to 3 herein.
4. A composition according to any preceding claim in tablet or capsule form.
5. A composition according to claim 4 which is in tablet form and wherein the excipient is present in an amount of 10 to 25 wtP/o.
6. A method of preparing a pharmaceutical composition according to claim 4 or claim 5 wherein a paste of 20% sago flour and/or modified sago flour or starch in boiling water is used as a granulating medium for the tablets or capsules.
**WARNING** end of DESC field may overlap start of CLMS **.
Claims (6)
1. A pharmaceutical composition comprising a pharmaceutically active ingredient, as an excipient, sago flour and/or a modified sago flour or starch.
2. Acomposition according to claim 1 wherein the excipient has a particle size of 20 to 65 microns.
3. A pharmaceutical composition substantially as herein described with reference to any one of Compositions 1 to 3 herein.
4. A composition according to any preceding claim in tablet or capsule form.
5. A composition according to claim 4 which is in tablet form and wherein the excipient is present in an amount of 10 to 25 wtP/o.
6. A method of preparing a pharmaceutical composition according to claim 4 or claim 5 wherein a paste of 20% sago flour and/or modified sago flour or starch in boiling water is used as a granulating medium for the tablets or capsules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7938519A GB2062459A (en) | 1979-11-07 | 1979-11-07 | Excipient for pharmaceutical compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7938519A GB2062459A (en) | 1979-11-07 | 1979-11-07 | Excipient for pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB2062459A true GB2062459A (en) | 1981-05-28 |
Family
ID=10509019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7938519A Withdrawn GB2062459A (en) | 1979-11-07 | 1979-11-07 | Excipient for pharmaceutical compositions |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2062459A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4369308A (en) * | 1981-07-24 | 1983-01-18 | National Starch And Chemical Corporation | Low swelling starches as tablet disintegrants |
-
1979
- 1979-11-07 GB GB7938519A patent/GB2062459A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4369308A (en) * | 1981-07-24 | 1983-01-18 | National Starch And Chemical Corporation | Low swelling starches as tablet disintegrants |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |