GB2055044B - Glucuronidase activity and/or phdependent pharmaceuticals and their methods of production and use for selective treatment of diseases - Google Patents
Glucuronidase activity and/or phdependent pharmaceuticals and their methods of production and use for selective treatment of diseasesInfo
- Publication number
- GB2055044B GB2055044B GB8015763A GB8015763A GB2055044B GB 2055044 B GB2055044 B GB 2055044B GB 8015763 A GB8015763 A GB 8015763A GB 8015763 A GB8015763 A GB 8015763A GB 2055044 B GB2055044 B GB 2055044B
- Authority
- GB
- United Kingdom
- Prior art keywords
- phdependent
- pharmaceuticals
- diseases
- production
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physiology (AREA)
- Optics & Photonics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/951,270 US4424348A (en) | 1978-10-13 | 1978-10-13 | Methods of manufacture of nitrile-containing glucuronic acid conjugates |
US05/951,269 US4584368A (en) | 1978-10-13 | 1978-10-13 | β-Glucuronidase activity and/or pH-dependent pharmaceuticals and thier methods of production |
US06/011,619 US4327074A (en) | 1978-10-13 | 1979-02-12 | Method for diagnosis and selective treatment of infections of bacteria having β-glucuronidase activity |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2055044A GB2055044A (en) | 1981-02-25 |
GB2055044B true GB2055044B (en) | 1983-04-20 |
Family
ID=27359461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8015763A Expired GB2055044B (en) | 1978-10-13 | 1979-10-02 | Glucuronidase activity and/or phdependent pharmaceuticals and their methods of production and use for selective treatment of diseases |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS55500837A (en) |
AU (1) | AU534068B2 (en) |
CA (1) | CA1148086A (en) |
CH (1) | CH652724A5 (en) |
DE (1) | DE2953223T1 (en) |
FR (2) | FR2440374B1 (en) |
GB (1) | GB2055044B (en) |
IL (1) | IL58352A (en) |
IT (1) | IT1164730B (en) |
NL (1) | NL7920107A (en) |
SE (1) | SE461983B (en) |
WO (1) | WO1980000791A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4490523A (en) * | 1981-11-10 | 1984-12-25 | Ely J. Rubin | Mandelonitrile triacetyl glucuronate and process for preparing same |
AU594855B2 (en) * | 1988-01-15 | 1990-03-15 | Baker Norton Pharmaceuticals, Inc. | Glucuronic acid derivatives of opioid antagonists |
DE59610819D1 (en) * | 1995-03-30 | 2003-12-18 | Werner Kreutz | MEDICINAL PRODUCTS FOR SELECTIVELY FIGHTING TUMOR TISSUE |
WO2014138723A2 (en) * | 2013-03-08 | 2014-09-12 | Cognate3 Llc | Physical optimization beverage |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB788855A (en) * | 1953-06-30 | 1958-01-08 | Ernst Theodore Krebs | Improvements in or relating to mandelo-nitrile-glucuronosides and method of making the same |
US2985664A (en) * | 1957-05-29 | 1961-05-23 | Ernst T Krebs | Hexuronic acid derivatives |
US3758455A (en) * | 1970-05-14 | 1973-09-11 | Chugai Pharmaceutical Co Ltd | Reof mycophenolic acid glucuronide and the process for the preparation the |
DE2212014A1 (en) * | 1971-04-21 | 1972-10-26 | Deutsche Akademie der Wissenschaf ten zu Berlin, χ 1199 Berlin | Enzymatic cleavage of chemotherapeutics transport forms - under acid conditions to give tumour-specific chemotherapy |
USRE29465E (en) * | 1972-08-14 | 1977-11-01 | Eli Lilly And Company | Psoriasis treatment with mycophenolic acid |
US3880995A (en) * | 1973-05-14 | 1975-04-29 | Lilly Co Eli | Treatment of arthritis with mycophenolic acid and derivatives |
US3959253A (en) * | 1973-07-02 | 1976-05-25 | Merck & Co., Inc. | β-D-glucosyluronic acid derivatives |
DD122386A1 (en) * | 1975-06-24 | 1976-10-05 | ||
JPS5325534A (en) * | 1976-08-24 | 1978-03-09 | Rikagaku Kenkyusho | Mandelic acid glucosides and their anti-cancerous preparations |
-
1979
- 1979-09-24 AU AU51120/79A patent/AU534068B2/en not_active Ceased
- 1979-09-28 IL IL58352A patent/IL58352A/en unknown
- 1979-10-02 DE DE792953223T patent/DE2953223T1/en active Granted
- 1979-10-02 NL NL7920107A patent/NL7920107A/en unknown
- 1979-10-02 CH CH4668/80A patent/CH652724A5/en not_active IP Right Cessation
- 1979-10-02 JP JP50180979A patent/JPS55500837A/ja active Pending
- 1979-10-02 GB GB8015763A patent/GB2055044B/en not_active Expired
- 1979-10-02 WO PCT/US1979/000809 patent/WO1980000791A1/en unknown
- 1979-10-10 FR FR7925183A patent/FR2440374B1/en not_active Expired
- 1979-10-11 IT IT50529/79A patent/IT1164730B/en active
- 1979-10-12 CA CA000337483A patent/CA1148086A/en not_active Expired
-
1980
- 1980-04-30 FR FR8009746A patent/FR2449284A1/en not_active Withdrawn
- 1980-06-12 SE SE8004369A patent/SE461983B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FR2440374A1 (en) | 1980-05-30 |
DE2953223T1 (en) | 1980-11-27 |
WO1980000791A1 (en) | 1980-05-01 |
IT1164730B (en) | 1987-04-15 |
CA1148086A (en) | 1983-06-14 |
AU534068B2 (en) | 1984-01-05 |
FR2440374B1 (en) | 1986-03-21 |
IT7950529A0 (en) | 1979-10-11 |
JPS55500837A (en) | 1980-10-23 |
SE461983B (en) | 1990-04-23 |
CH652724A5 (en) | 1985-11-29 |
SE8004369L (en) | 1980-06-12 |
NL7920107A (en) | 1980-08-29 |
DE2953223C2 (en) | 1989-05-18 |
GB2055044A (en) | 1981-02-25 |
AU5112079A (en) | 1981-04-16 |
IL58352A (en) | 1985-11-29 |
FR2449284A1 (en) | 1980-09-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19931002 |