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GB2013672A - Process for the Production of Monorden and Derivatives Thereof - Google Patents

Process for the Production of Monorden and Derivatives Thereof

Info

Publication number
GB2013672A
GB2013672A GB7903327A GB7903327A GB2013672A GB 2013672 A GB2013672 A GB 2013672A GB 7903327 A GB7903327 A GB 7903327A GB 7903327 A GB7903327 A GB 7903327A GB 2013672 A GB2013672 A GB 2013672A
Authority
GB
United Kingdom
Prior art keywords
monorden
derivatives
production
new derivatives
cultivation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7903327A
Other versions
GB2013672B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WR Grace and Co
Original Assignee
WR Grace and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/874,207 external-priority patent/US4166764A/en
Priority claimed from US05/955,705 external-priority patent/US4228079A/en
Application filed by WR Grace and Co filed Critical WR Grace and Co
Publication of GB2013672A publication Critical patent/GB2013672A/en
Application granted granted Critical
Publication of GB2013672B publication Critical patent/GB2013672B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Monorden is produced by cultivation of Diheterospora chlamydosporia. The cultivation takes place in a nutrient medium and the monorden is isolated by adsorption or extraction. It may be converted by alkylation into new derivatives of the formula: <IMAGE> wherein R is alkyl of 2 to 8 carbon atoms, the two R groups being the same or different. Monorden is a known anti-tumour agent. The new derivatives are anti-tumour agents and nematocides.
GB7903327A 1978-02-01 1979-01-31 Process for the production of monorden and derivatives thereof Expired GB2013672B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87434878A 1978-02-01 1978-02-01
US05/874,207 US4166764A (en) 1978-02-01 1978-02-01 Production of monorden
US05/955,705 US4228079A (en) 1978-10-30 1978-10-30 Dialkoxy monorden derivatives

Publications (2)

Publication Number Publication Date
GB2013672A true GB2013672A (en) 1979-08-15
GB2013672B GB2013672B (en) 1982-06-09

Family

ID=27420481

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7903327A Expired GB2013672B (en) 1978-02-01 1979-01-31 Process for the production of monorden and derivatives thereof

Country Status (4)

Country Link
DE (1) DE2903997A1 (en)
GB (1) GB2013672B (en)
NL (1) NL7900817A (en)
SE (1) SE7900855L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650430A (en) * 1990-06-06 1997-07-22 Sankyo Company, Limited Radicicol derivatives, their preparation and their anti-tumor activity
KR920000763A (en) * 1990-06-06 1992-01-29 가와무라 요시부미 Radicicol derivatives, preparation method thereof and antitumor activity thereof

Also Published As

Publication number Publication date
GB2013672B (en) 1982-06-09
SE7900855L (en) 1979-08-02
DE2903997A1 (en) 1979-09-06
NL7900817A (en) 1979-08-03

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee