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GB2013667A - 7-(1-Hydroxyethyl)-8-Oxo-3- Oxa-1-Azabicyclo[4.2.0]Octanes and Esters Thereof - Google Patents

7-(1-Hydroxyethyl)-8-Oxo-3- Oxa-1-Azabicyclo[4.2.0]Octanes and Esters Thereof

Info

Publication number
GB2013667A
GB2013667A GB7902370A GB7902370A GB2013667A GB 2013667 A GB2013667 A GB 2013667A GB 7902370 A GB7902370 A GB 7902370A GB 7902370 A GB7902370 A GB 7902370A GB 2013667 A GB2013667 A GB 2013667A
Authority
GB
United Kingdom
Prior art keywords
octanes
azabicyclo
oxa
oxo
hydroxyethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7902370A
Other versions
GB2013667B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB7902370A priority Critical patent/GB2013667B/en
Publication of GB2013667A publication Critical patent/GB2013667A/en
Application granted granted Critical
Publication of GB2013667B publication Critical patent/GB2013667B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

This invention provides the compounds of the formula (III): <IMAGE> wherein R1 is an alkyl group of up to carbon atoms and R2 is an alkyl group of up to 3 carbon atoms optionally joined to R1 so that R1 and R2 and the carbon atom to which they are attached form a spiro-cyclopentyl or spiro-cyclohexyl ring, and wherein the configuration about the ???-lactam ring is trans, which are useful in the preparation of antibacterial beta -lactam compounds. The invention also discloses a process for the preparation of the compounds of the formula (III).
GB7902370A 1978-02-02 1979-01-23 Chemical intemediates Expired GB2013667B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB7902370A GB2013667B (en) 1978-02-02 1979-01-23 Chemical intemediates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB417878 1978-02-02
GB7902370A GB2013667B (en) 1978-02-02 1979-01-23 Chemical intemediates

Publications (2)

Publication Number Publication Date
GB2013667A true GB2013667A (en) 1979-08-15
GB2013667B GB2013667B (en) 1982-06-30

Family

ID=26238943

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7902370A Expired GB2013667B (en) 1978-02-02 1979-01-23 Chemical intemediates

Country Status (1)

Country Link
GB (1) GB2013667B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0093485A2 (en) * 1982-03-16 1983-11-09 Beecham Group Plc Process for the preparation of substituted 3-oxa-1-aza-bicyclo(4.2.0)octan-8-ones, and intermediates obtained thereby
US4443599A (en) * 1981-05-14 1984-04-17 Beecham Group P.L.C. 8-Oxo-3-oxa-1-azabicyclo[4.2.0]octanes containing a chiral center

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443599A (en) * 1981-05-14 1984-04-17 Beecham Group P.L.C. 8-Oxo-3-oxa-1-azabicyclo[4.2.0]octanes containing a chiral center
EP0093485A2 (en) * 1982-03-16 1983-11-09 Beecham Group Plc Process for the preparation of substituted 3-oxa-1-aza-bicyclo(4.2.0)octan-8-ones, and intermediates obtained thereby
EP0093485A3 (en) * 1982-03-16 1985-04-10 Beecham Group Plc Process for the preparation of substituted 3-oxa-1-aza-bicyclo(4.2.0)octan-8-ones, and intermediates obtained thereby

Also Published As

Publication number Publication date
GB2013667B (en) 1982-06-30

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee