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GB201320366D0 - Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein - Google Patents

Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Info

Publication number
GB201320366D0
GB201320366D0 GBGB1320366.6A GB201320366A GB201320366D0 GB 201320366 D0 GB201320366 D0 GB 201320366D0 GB 201320366 A GB201320366 A GB 201320366A GB 201320366 D0 GB201320366 D0 GB 201320366D0
Authority
GB
United Kingdom
Prior art keywords
hydroxylase
dopamine
peripherally
intermediates
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1320366.6A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bilal Portela & Ca S A
Original Assignee
Bilal Portela & Ca S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bilal Portela & Ca S A filed Critical Bilal Portela & Ca S A
Publication of GB201320366D0 publication Critical patent/GB201320366D0/en
Priority to ES14772233T priority Critical patent/ES2807587T3/en
Priority to MX2016003211A priority patent/MX2016003211A/en
Priority to CA2923164A priority patent/CA2923164A1/en
Priority to PT147722334T priority patent/PT3044215T/en
Priority to EP20171586.9A priority patent/EP3808737A1/en
Priority to US15/021,605 priority patent/US10329268B2/en
Priority to RU2016113965A priority patent/RU2016113965A/en
Priority to EP14772233.4A priority patent/EP3044215B1/en
Priority to JP2016541935A priority patent/JP6629209B2/en
Priority to CN201480050660.9A priority patent/CN105555775A/en
Priority to PCT/PT2014/000061 priority patent/WO2015038022A1/en
Priority to AU2014319051A priority patent/AU2014319051A1/en
Priority to KR1020167009649A priority patent/KR20160055258A/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
GBGB1320366.6A 2013-09-13 2013-11-18 Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein Ceased GB201320366D0 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
KR1020167009649A KR20160055258A (en) 2013-09-13 2014-09-12 Processes for preparing medicaments for the treatment of cardiovascular diseases and intermediates for use therein
RU2016113965A RU2016113965A (en) 2013-09-13 2014-09-12 METHODS FOR PRODUCING MEDICINES FOR TREATMENT OF CARDIOVASCULAR DISEASES AND INTERMEDIATES FOR THEIR USE
EP14772233.4A EP3044215B1 (en) 2013-09-13 2014-09-12 Processes for preparing medicaments for the treatment of cardiovascular diseases and intermediates for use therein
CA2923164A CA2923164A1 (en) 2013-09-13 2014-09-12 Processes for preparing medicaments for the treatment of cardiovascular diseases and intermediates for use therein
PT147722334T PT3044215T (en) 2013-09-13 2014-09-12 Processes for preparing medicaments for the treatment of cardiovascular diseases and intermediates for use therein
EP20171586.9A EP3808737A1 (en) 2013-09-13 2014-09-12 Processes for preparing medicaments for the treatment of cardiovascular diseases and intermediates for use therein
US15/021,605 US10329268B2 (en) 2013-09-13 2014-09-12 Processes for preparing medicaments for the treatment of cardiovascular diseases and intermediates for use therein
ES14772233T ES2807587T3 (en) 2013-09-13 2014-09-12 Procedures for the preparation of drugs for the treatment of cardiovascular diseases and intermediates for use in these
MX2016003211A MX2016003211A (en) 2013-09-13 2014-09-12 Processes for preparing medicaments for the treatment of cardiovascular diseases and intermediates for use therein.
JP2016541935A JP6629209B2 (en) 2013-09-13 2014-09-12 Method for preparing a medicament for treating cardiovascular disease and method for preparing an intermediate used for the preparation
CN201480050660.9A CN105555775A (en) 2013-09-13 2014-09-12 Processes for preparing medicaments for the treatment of cardiovascular diseases and intermediates for use therein
PCT/PT2014/000061 WO2015038022A1 (en) 2013-09-13 2014-09-12 Processes for preparing medicaments for the treatment of cardiovascular diseases and intermediates for use therein
AU2014319051A AU2014319051A1 (en) 2013-09-13 2014-09-12 Processes for preparing medicaments for the treatment of cardiovascular diseases and intermediates for use therein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1316410.8A GB201316410D0 (en) 2013-09-13 2013-09-13 Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Publications (1)

Publication Number Publication Date
GB201320366D0 true GB201320366D0 (en) 2014-01-01

Family

ID=49552693

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB1316410.8A Ceased GB201316410D0 (en) 2013-09-13 2013-09-13 Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein
GBGB1320366.6A Ceased GB201320366D0 (en) 2013-09-13 2013-11-18 Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB1316410.8A Ceased GB201316410D0 (en) 2013-09-13 2013-09-13 Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Country Status (13)

Country Link
US (1) US10329268B2 (en)
EP (2) EP3044215B1 (en)
JP (1) JP6629209B2 (en)
KR (1) KR20160055258A (en)
CN (1) CN105555775A (en)
AU (1) AU2014319051A1 (en)
CA (1) CA2923164A1 (en)
ES (1) ES2807587T3 (en)
GB (2) GB201316410D0 (en)
MX (1) MX2016003211A (en)
PT (1) PT3044215T (en)
RU (1) RU2016113965A (en)
WO (1) WO2015038022A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein
GB201810395D0 (en) 2018-06-25 2018-08-08 Bial Portela & Ca Sa Formulations comprising dopamine-beta-hydroxylase inhibitors and methods for their preparation

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8904361D0 (en) 1989-12-22 1989-12-22 Astra Ab NEW CHROMAN AND THIOCHROMAN DERIVATIVES
FR2689509B1 (en) 1992-04-01 1994-06-03 Adir NEW SPIRANIC DERIVATIVES OF 3-AMINO CHROMANE, THEIR PREPARATION METHODS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
WO1995007284A1 (en) * 1993-09-09 1995-03-16 Smithkline Beecham Plc Phosphinic acid derivatives with anti-hyper glycemic and/or anti-obesity activity
FR2746395B1 (en) 1996-03-22 1998-04-17 Adir NOVEL ARYLETHANOLAMINE AND ARYLOXYPROPANOLAMINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ES2263487T3 (en) 1999-09-20 2006-12-16 The Penn State Research Foundation CHIRAL PHOSPHINES, METAL TRANSITION COMPLEXES OF THE SAME AND ITS USES IN ASYMMETRIC REACTIONS.
US7125904B2 (en) 2002-10-11 2006-10-24 Portela & C.A., S.A. Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation
GB2393958A (en) * 2002-10-11 2004-04-14 Portela & Ca Sa Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase
US20050032873A1 (en) 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
JP4619413B2 (en) 2004-10-12 2011-01-26 ファーマコペイア ドラッグ ディスカバリー， インコーポレイテッド Bicyclic compounds as selective melanin-concentrating hormone receptor antagonists for the treatment of obesity and related disorders
GR1005093B (en) * 2005-02-01 2006-01-13 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος" Scyphostatin analogues and intermediates in the production thereof
GB0708818D0 (en) 2007-05-08 2007-06-13 Portela & Ca Sa Compounds
TW200927740A (en) * 2007-11-13 2009-07-01 Bial Portela & Ca Sa Process
AR070841A1 (en) * 2008-03-13 2010-05-05 Bial Portela & Ca Sa ASYMMETRIC CATALYTIC HYDROGENATION PROCESS
EP2401366B1 (en) 2009-02-26 2013-12-18 Codexis, Inc. Transaminase biocatalysts
EP2593556B1 (en) * 2010-07-14 2017-08-30 DPx Holdings B.V. Enzymatic method for (r)-selective amination
CN102153533B (en) 2011-01-29 2013-02-27 中山大学 A kind of 3-nitro-2H-chromene compound with antibacterial activity and its preparation method and application
WO2012175654A1 (en) 2011-06-23 2012-12-27 Facultes Universitaires Notre-Dame De La Paix Tetraline sulfonamide derivatives for use in the treatment of proliferative disorders
JP5981539B2 (en) * 2011-06-29 2016-08-31 バイアル−ポルテラ アンド シーエー，エス．エー． process
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Also Published As

Publication number Publication date
EP3808737A1 (en) 2021-04-21
EP3044215B1 (en) 2020-04-29
MX2016003211A (en) 2016-08-08
JP2016535066A (en) 2016-11-10
EP3044215A1 (en) 2016-07-20
WO2015038022A1 (en) 2015-03-19
ES2807587T3 (en) 2021-02-23
GB201316410D0 (en) 2013-10-30
US10329268B2 (en) 2019-06-25
CN105555775A (en) 2016-05-04
RU2016113965A (en) 2017-10-18
JP6629209B2 (en) 2020-01-15
RU2016113965A3 (en) 2018-06-08
CA2923164A1 (en) 2015-03-19
AU2014319051A1 (en) 2016-03-24
KR20160055258A (en) 2016-05-17
PT3044215T (en) 2020-07-27
US20160221981A1 (en) 2016-08-04

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)