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GB1583961A - Prostacyclin and derivatives thereof - Google Patents

Prostacyclin and derivatives thereof Download PDF

Info

Publication number
GB1583961A
GB1583961A GB19384/76A GB1938476A GB1583961A GB 1583961 A GB1583961 A GB 1583961A GB 19384/76 A GB19384/76 A GB 19384/76A GB 1938476 A GB1938476 A GB 1938476A GB 1583961 A GB1583961 A GB 1583961A
Authority
GB
United Kingdom
Prior art keywords
compound
deoxy
didehydro
sodium
prostaglandin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB19384/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB1938676A priority Critical patent/GB1583962A/en
Priority to GB19384/76A priority patent/GB1583961A/en
Priority to FR7710593A priority patent/FR2351111A1/fr
Priority to DK205377A priority patent/DK149953C/da
Priority to JP5361977A priority patent/JPS52136161A/ja
Priority to CH583777A priority patent/CH637948A5/de
Priority to AU25049/77A priority patent/AU515715B2/en
Priority to SE7705423A priority patent/SE436647B/sv
Priority to CA278,111A priority patent/CA1097239A/en
Priority to BE177444A priority patent/BE854463A/xx
Priority to IE950/77A priority patent/IE46036B1/en
Priority to NZ184057A priority patent/NZ184057A/xx
Priority to ZA00772795A priority patent/ZA772795B/xx
Priority to US06/795,524 priority patent/US4539333A/en
Priority to ES458639A priority patent/ES458639A1/es
Priority to NLAANVRAGE7705141,A priority patent/NL181973C/xx
Priority to IL52053A priority patent/IL52053A/xx
Priority to DE2720999A priority patent/DE2720999C2/de
Publication of GB1583961A publication Critical patent/GB1583961A/en
Priority to AU68231/81A priority patent/AU6823181A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Furan Compounds (AREA)
GB19384/76A 1976-05-11 1976-05-11 Prostacyclin and derivatives thereof Expired GB1583961A (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
GB1938676A GB1583962A (en) 1976-05-11 1976-05-11 Prostacyclin derivatives
GB19384/76A GB1583961A (en) 1976-05-11 1976-05-11 Prostacyclin and derivatives thereof
FR7710593A FR2351111A1 (fr) 1976-05-11 1977-04-07 Methylacetals de 2-(2b-ethynyl-cyclopent-1a-yl) acetaldehydes et leur preparation
BE177444A BE854463A (fr) 1976-05-11 1977-05-10 Ethers de prostaglandines
ZA00772795A ZA772795B (en) 1976-05-11 1977-05-10 Ethers
CH583777A CH637948A5 (en) 1976-05-11 1977-05-10 Process for the preparation of prostaglandin derivatives
AU25049/77A AU515715B2 (en) 1976-05-11 1977-05-10 Prostacyclin
SE7705423A SE436647B (sv) 1976-05-11 1977-05-10 Forfarande for framstellning av prostaglandinderivat (prostacyclin)
CA278,111A CA1097239A (en) 1976-05-11 1977-05-10 Enzymatic preparation of prostacyclin and its salts
DK205377A DK149953C (da) 1976-05-11 1977-05-10 Analogifremgangsmaade til fremstilling af prostaglandin-derivater
IE950/77A IE46036B1 (en) 1976-05-11 1977-05-10 Prostacyclin and derivatives thereof
NZ184057A NZ184057A (en) 1976-05-11 1977-05-10 Prostaglandin derivatives and pharmaceutica composition
JP5361977A JPS52136161A (en) 1976-05-11 1977-05-10 Novel prostaglandin derivative* its preparation and its use
US06/795,524 US4539333A (en) 1976-05-11 1977-05-10 Prostacyclin, methods of using and method of making
ES458639A ES458639A1 (es) 1976-05-11 1977-05-10 Un procedimiento para preparar derivados de prostaglandina.
NLAANVRAGE7705141,A NL181973C (nl) 1976-05-11 1977-05-10 Werkwijze voor het bereiden van farmaceutische preparaten op basis van prostaglandinederivaten en werkwijze voor het bereiden van prostaglandinederivaten.
IL52053A IL52053A (en) 1976-05-11 1977-05-10 Prostacyclin and its biological preparation
DE2720999A DE2720999C2 (de) 1976-05-11 1977-05-10 Postacyclin (bzw. (5Z)-5,6-Didehydro-9-desoxy-6,9α-epoxyprostaglandin F↓1↓↓α↓), Verfahren zu dessen Herstellung und diese Verbindung enthaltende pharmazeutische Formulierungen
AU68231/81A AU6823181A (en) 1976-05-11 1981-03-10 Prostacyclin salts

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB19384/76A GB1583961A (en) 1976-05-11 1976-05-11 Prostacyclin and derivatives thereof
GB3415176 1976-08-17
GB3654776 1976-09-03
GB4344576 1976-10-20
GB5306076 1976-12-20
GB1338977 1977-03-30

Publications (1)

Publication Number Publication Date
GB1583961A true GB1583961A (en) 1981-02-04

Family

ID=27546654

Family Applications (1)

Application Number Title Priority Date Filing Date
GB19384/76A Expired GB1583961A (en) 1976-05-11 1976-05-11 Prostacyclin and derivatives thereof

Country Status (12)

Country Link
JP (1) JPS52136161A (sv)
BE (1) BE854463A (sv)
CH (1) CH637948A5 (sv)
DE (1) DE2720999C2 (sv)
DK (1) DK149953C (sv)
FR (1) FR2351111A1 (sv)
GB (1) GB1583961A (sv)
IE (1) IE46036B1 (sv)
IL (1) IL52053A (sv)
NL (1) NL181973C (sv)
NZ (1) NZ184057A (sv)
SE (1) SE436647B (sv)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9492422B2 (en) 2009-11-13 2016-11-15 Toray Industries, Inc. Therapeutic or prophylactic agent for diabetes
WO2017162668A1 (en) 2016-03-23 2017-09-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Process for the preparation of epoprostenol sodium of enhanced stability

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI71138C (fi) * 1976-12-31 1986-11-24 Erba Farmitalia Foerfarande foer framstaellning av terapeutiskt aktiva bisykliska prostaglandiner
HU182583B (en) * 1977-03-01 1984-02-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing prostacyclin and analogues thereof
DE2743283A1 (de) * 1977-09-27 1979-04-05 Hoechst Ag Neue prostacyclin-analoga
IT1088036B (it) 1977-11-25 1985-06-04 Erba Carlo Spa 15-epi-prostaciclina e prostaciclina analoghi
DE2811950A1 (de) * 1978-03-18 1979-12-13 Hoechst Ag Neue analoga von prostacyclin
ZA787353B (en) * 1978-05-17 1980-08-27 Wellcome Found Pharmaceutical formulations
US4430340A (en) * 1978-07-17 1984-02-07 The Upjohn Company Stabilization of PGI2 compounds with surfactants
IL58384A0 (en) 1978-10-14 1980-01-31 Beecham Group Ltd 12-aza analogues of prostcyclin their preparation and pharmaceutical composition containing them
ZA815504B (en) * 1980-09-15 1982-08-25 Upjohn Co Crystalline pgi2 methyl ester
CH648556A5 (de) * 1981-03-11 1985-03-29 Hoffmann La Roche Fluorprostacycline.
DE3438870A1 (de) * 1983-12-13 1985-06-13 Stellmacher, Gerhard, Ing.(grad.), 8501 Schwaig Spannvorrichtung fuer holzbearbeitungsmaschinen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9492422B2 (en) 2009-11-13 2016-11-15 Toray Industries, Inc. Therapeutic or prophylactic agent for diabetes
WO2017162668A1 (en) 2016-03-23 2017-09-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Process for the preparation of epoprostenol sodium of enhanced stability

Also Published As

Publication number Publication date
IL52053A (en) 1983-09-30
JPS619953B2 (sv) 1986-03-27
DK149953C (da) 1987-06-29
IE46036L (en) 1977-11-11
BE854463A (fr) 1977-11-10
DE2720999C2 (de) 1986-09-18
NL7705141A (nl) 1977-11-15
FR2351111A1 (fr) 1977-12-09
IL52053A0 (en) 1977-07-31
SE7705423L (sv) 1977-11-12
JPS52136161A (en) 1977-11-14
DK149953B (da) 1986-11-03
IE46036B1 (en) 1983-02-09
DK205377A (da) 1977-11-12
DE2720999A1 (de) 1977-11-24
NL181973C (nl) 1987-12-16
NL181973B (nl) 1987-07-16
NZ184057A (en) 1979-10-25
CH637948A5 (en) 1983-08-31
SE436647B (sv) 1985-01-14

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
48S Specification amended (sect. 8/1949)
SP Amendment (slips) printed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19970509