GB1529992A - Anthracycline glycosides - Google Patents
Anthracycline glycosidesInfo
- Publication number
- GB1529992A GB1529992A GB28985/76A GB2898576A GB1529992A GB 1529992 A GB1529992 A GB 1529992A GB 28985/76 A GB28985/76 A GB 28985/76A GB 2898576 A GB2898576 A GB 2898576A GB 1529992 A GB1529992 A GB 1529992A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dideoxy
- ome
- july
- halogen
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
1529992 Daunorubicin derivatives SOC FARMACEUTICI ITALIA SpA 8 July 1977 [13 July 1976] 28985/76 Heading C2C Compounds of the general formula (R 1,3 = H, R 2 = H, halogen, Me, OMe; R 1 , 2 = H, R 3 = C 1-4 alkoxy; or R 2 = H, R 1 = R 3 = halogen, Me, OMe) and their 14-hydroxy derivatives and hydrochlorides are prepared by reacting the corresponding aglycone with 3,6-dideoxy - 2,4 - bis(p - nitrobenzoyl) - 3 - trifluoroacetamido - α - L - talohexopyranosyl bromide, followed by removal of the protecting groups and, optionally, bromination and hydrolysis and/or salt formation. The compounds are antimitotics. The bromosugar is prepared by reacting 3- amino - 3,6 - dideoxy - L - talohexose hydrochloride with trifluoroacetic anhydride, removing the O-trifluoroacetyl groups, esterifying with p-nitrobenzoyl chloride and treating the product with hydrogen bromide.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB28985/76A GB1529992A (en) | 1976-07-13 | 1976-07-13 | Anthracycline glycosides |
| DE19772731286 DE2731286A1 (en) | 1976-07-13 | 1977-07-11 | ANTHRACYCLING LYCOSIDE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB28985/76A GB1529992A (en) | 1976-07-13 | 1976-07-13 | Anthracycline glycosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1529992A true GB1529992A (en) | 1978-10-25 |
Family
ID=10284414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28985/76A Expired GB1529992A (en) | 1976-07-13 | 1976-07-13 | Anthracycline glycosides |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE2731286A1 (en) |
| GB (1) | GB1529992A (en) |
-
1976
- 1976-07-13 GB GB28985/76A patent/GB1529992A/en not_active Expired
-
1977
- 1977-07-11 DE DE19772731286 patent/DE2731286A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE2731286A1 (en) | 1978-01-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |