GB1517026A - Immune globulins and process for their preparation - Google Patents
Immune globulins and process for their preparationInfo
- Publication number
- GB1517026A GB1517026A GB36451/75A GB3645175A GB1517026A GB 1517026 A GB1517026 A GB 1517026A GB 36451/75 A GB36451/75 A GB 36451/75A GB 3645175 A GB3645175 A GB 3645175A GB 1517026 A GB1517026 A GB 1517026A
- Authority
- GB
- United Kingdom
- Prior art keywords
- immunoglobulins
- preparation
- immune globulins
- sulphydryl
- amidated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Amidated immunoglobulins suitable for intravenous administration are prepared by reacting immunoglobulins with a molar excess of a primary monoamine and a carbodiimide or its salt in weakly acidic to neutral aqueous solution. As a result of the amidation, the undesired complement binding by the immunoglobulins is prevented or at least substantially decreased without the antibody action of the immunoglobulins being impaired. The process can be applied to reduced immunoglobulins, in which at least one disulphide bond has been converted to two sulphydryl bonds.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2442655A DE2442655C3 (en) | 1974-09-06 | 1974-09-06 | Amidated immunoglobulins and their use for intravenous administration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1517026A true GB1517026A (en) | 1978-07-05 |
Family
ID=5925019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB36451/75A Expired GB1517026A (en) | 1974-09-06 | 1975-09-04 | Immune globulins and process for their preparation |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5161623A (en) |
| AR (1) | AR212909A1 (en) |
| AT (1) | AT342763B (en) |
| AU (1) | AU499871B2 (en) |
| BE (1) | BE833186A (en) |
| BR (1) | BR7505721A (en) |
| CA (1) | CA1056819A (en) |
| CH (1) | CH615194A5 (en) |
| DE (1) | DE2442655C3 (en) |
| DK (1) | DK399175A (en) |
| EG (1) | EG11813A (en) |
| FR (1) | FR2283695A1 (en) |
| GB (1) | GB1517026A (en) |
| IE (1) | IE41671B1 (en) |
| IL (1) | IL48049A (en) |
| IT (1) | IT1048485B (en) |
| LU (1) | LU73328A1 (en) |
| NL (1) | NL7510289A (en) |
| NZ (1) | NZ178580A (en) |
| SE (1) | SE403704B (en) |
| ZA (1) | ZA755687B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5004697A (en) * | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3704282A (en) * | 1971-04-09 | 1972-11-28 | Sidney Spector | Catecholamine antigens and antibodies specific therefor |
-
1974
- 1974-09-06 DE DE2442655A patent/DE2442655C3/en not_active Expired
-
1975
- 1975-09-01 NL NL7510289A patent/NL7510289A/en not_active Application Discontinuation
- 1975-09-04 AU AU84536/75A patent/AU499871B2/en not_active Expired
- 1975-09-04 NZ NZ178580A patent/NZ178580A/en unknown
- 1975-09-04 GB GB36451/75A patent/GB1517026A/en not_active Expired
- 1975-09-04 IL IL48049A patent/IL48049A/en unknown
- 1975-09-04 IT IT26918/75A patent/IT1048485B/en active
- 1975-09-04 LU LU73328A patent/LU73328A1/xx unknown
- 1975-09-04 CH CH1147275A patent/CH615194A5/en not_active IP Right Cessation
- 1975-09-05 AT AT689475A patent/AT342763B/en not_active IP Right Cessation
- 1975-09-05 IE IE1944/75A patent/IE41671B1/en unknown
- 1975-09-05 BR BR7505721*A patent/BR7505721A/en unknown
- 1975-09-05 FR FR7527354A patent/FR2283695A1/en active Granted
- 1975-09-05 SE SE7509898A patent/SE403704B/en unknown
- 1975-09-05 CA CA235,134A patent/CA1056819A/en not_active Expired
- 1975-09-05 DK DK399175A patent/DK399175A/en not_active Application Discontinuation
- 1975-09-05 ZA ZA00755687A patent/ZA755687B/en unknown
- 1975-09-06 EG EG521/75A patent/EG11813A/en active
- 1975-09-06 JP JP50107581A patent/JPS5161623A/ja active Pending
- 1975-09-08 BE BE159842A patent/BE833186A/en unknown
- 1975-09-14 AR AR260263A patent/AR212909A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| ZA755687B (en) | 1976-08-25 |
| IE41671L (en) | 1976-03-06 |
| NL7510289A (en) | 1976-03-09 |
| DE2442655C3 (en) | 1979-09-20 |
| AU8453675A (en) | 1977-03-10 |
| CA1056819A (en) | 1979-06-19 |
| IT1048485B (en) | 1980-11-20 |
| IL48049A0 (en) | 1975-11-25 |
| LU73328A1 (en) | 1977-05-11 |
| SE7509898L (en) | 1976-03-08 |
| ATA689475A (en) | 1977-08-15 |
| BE833186A (en) | 1976-03-08 |
| EG11813A (en) | 1978-09-30 |
| FR2283695B1 (en) | 1978-09-22 |
| FR2283695A1 (en) | 1976-04-02 |
| AR212909A1 (en) | 1978-11-15 |
| JPS5161623A (en) | 1976-05-28 |
| NZ178580A (en) | 1978-03-06 |
| IL48049A (en) | 1978-08-31 |
| SE403704B (en) | 1978-09-04 |
| BR7505721A (en) | 1976-08-03 |
| AU499871B2 (en) | 1979-05-03 |
| CH615194A5 (en) | 1980-01-15 |
| IE41671B1 (en) | 1980-02-27 |
| AT342763B (en) | 1978-04-25 |
| DE2442655B2 (en) | 1979-02-01 |
| DE2442655A1 (en) | 1976-03-18 |
| DK399175A (en) | 1976-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |