GB1507215A - Processes for producing immunoregulatory preparations - Google Patents
Processes for producing immunoregulatory preparationsInfo
- Publication number
- GB1507215A GB1507215A GB34465/75A GB3446575A GB1507215A GB 1507215 A GB1507215 A GB 1507215A GB 34465/75 A GB34465/75 A GB 34465/75A GB 3446575 A GB3446575 A GB 3446575A GB 1507215 A GB1507215 A GB 1507215A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fraction
- ira
- globulin
- producing
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 230000004957 immunoregulator effect Effects 0.000 title 1
- 239000008280 blood Substances 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000000706 filtrate Substances 0.000 abstract 2
- 108010068307 Alpha-Globulins Proteins 0.000 abstract 1
- 102000002572 Alpha-Globulins Human genes 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 150000002016 disaccharides Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 150000008282 halocarbons Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 108010033538 immunoregulatory alpha globulin Proteins 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002772 monosaccharides Chemical class 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000003169 placental effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 150000005846 sugar alcohols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4717—Plasma globulins, lactoglobulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1507215 Process for producing α-globulin formulation GREEN CROSS CORP 19 Aug 1975 34465/75 Heading A5B [Also in Division C3] A process for producing an IRA (immunoregulatory α-globulin) preparation comprises treating an aqueous solution of human blood or an α 2 -globulin-containing fraction thereof with an acid at pH of 5.0 or less at ambient temperature for 30 minutes to 24 hours, filtering the treated solution with a filter capable of leaving in the filtrate a fraction having a M.W. of 13000 or less, removing impurities in the filtrate by adsorption on a weakly acid cation exchanger, adsorbing the IRA on an inorganic (including active carbon) adsorbent and eluting the IRA with an aqueous acid or organic solvent. The blood fraction may be plasma or placental blood, particularly Cohn's Fraction IV. The eluate may be further purified by extraction with a halogenated hydrocarbon or an ether. Any HB-Ag activity in the preparation may be inactivated by heating in the presence of a stabilizer which. may be a neutral amino acid, a sugar alcohol, a monosaccharide or disaccharide, which is removed by dialysis.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB34465/75A GB1507215A (en) | 1975-08-19 | 1975-08-19 | Processes for producing immunoregulatory preparations |
| JP51033421A JPS597695B2 (en) | 1975-08-19 | 1976-03-26 | Peptide preparations with immunoregulatory effects |
| JP58181733A JPS5930686B2 (en) | 1975-08-19 | 1983-09-29 | Method for producing peptides with immunoregulatory effects |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB34465/75A GB1507215A (en) | 1975-08-19 | 1975-08-19 | Processes for producing immunoregulatory preparations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1507215A true GB1507215A (en) | 1978-04-12 |
Family
ID=10365996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB34465/75A Expired GB1507215A (en) | 1975-08-19 | 1975-08-19 | Processes for producing immunoregulatory preparations |
Country Status (2)
| Country | Link |
|---|---|
| JP (2) | JPS597695B2 (en) |
| GB (1) | GB1507215A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1640012A1 (en) * | 2004-09-24 | 2006-03-29 | Salama, Zoser B. nat.rer.Dr. | Pharmaceuticals agents comprising blood components 10 kDa and their use for prophylaxis and treatment of defects of the immune system |
| WO2006032269A2 (en) * | 2004-09-24 | 2006-03-30 | Salama Zoser B | Pharmaceutical product containing blood constituents and or kda, and the use of the same for the prophylaxis and treatment of defects of the immune system |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5851113B2 (en) * | 1979-09-19 | 1983-11-14 | コニシ株式会社 | How to repair cracks in concrete, etc. |
| DE3176491D1 (en) * | 1980-03-05 | 1987-11-26 | Miles Lab | Pasteurized therapeutically active protein compositions |
| US4481189A (en) * | 1982-04-14 | 1984-11-06 | New York Blood Center Inc. | Process for preparing sterilized plasma and plasma derivatives |
| KR101121198B1 (en) | 2009-05-20 | 2012-03-23 | (주)노바셀테크놀로지 | Peptide mixture extracted from human placenta, and preparation method and use thereof |
-
1975
- 1975-08-19 GB GB34465/75A patent/GB1507215A/en not_active Expired
-
1976
- 1976-03-26 JP JP51033421A patent/JPS597695B2/en not_active Expired
-
1983
- 1983-09-29 JP JP58181733A patent/JPS5930686B2/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1640012A1 (en) * | 2004-09-24 | 2006-03-29 | Salama, Zoser B. nat.rer.Dr. | Pharmaceuticals agents comprising blood components 10 kDa and their use for prophylaxis and treatment of defects of the immune system |
| WO2006032269A2 (en) * | 2004-09-24 | 2006-03-30 | Salama Zoser B | Pharmaceutical product containing blood constituents and or kda, and the use of the same for the prophylaxis and treatment of defects of the immune system |
| WO2006032269A3 (en) * | 2004-09-24 | 2006-06-15 | Zoser B Salama | Pharmaceutical product containing blood constituents and or kda, and the use of the same for the prophylaxis and treatment of defects of the immune system |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5980612A (en) | 1984-05-10 |
| JPS597695B2 (en) | 1984-02-20 |
| JPS5930686B2 (en) | 1984-07-28 |
| JPS5225020A (en) | 1977-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |