[go: up one dir, main page]

GB1502405A - Preparation of quinoline derivatives - Google Patents

Preparation of quinoline derivatives

Info

Publication number
GB1502405A
GB1502405A GB23285/76A GB2328576A GB1502405A GB 1502405 A GB1502405 A GB 1502405A GB 23285/76 A GB23285/76 A GB 23285/76A GB 2328576 A GB2328576 A GB 2328576A GB 1502405 A GB1502405 A GB 1502405A
Authority
GB
United Kingdom
Prior art keywords
optionally substituted
hydrogen
aralkyl
nitrogen
quinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23285/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of GB1502405A publication Critical patent/GB1502405A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1502405 Quinoline-3-carboxylic acid derivatives CHINOIN GYOGYSZER ES UEGYESZETI TERMEKEK GYARA RT 4 June 1976 [6 June 1975] 23285/76 Heading C2C A process for preparing quinoline-3-carboxylic acids having the general Formula I wherein n is 0 or 1; R is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, or optionally substituted aralkyl; R<SP>1</SP> is hydrogen, halogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted cycloalkyl or cycloalkylalkyl, optionally substituted amino, hydroxy, optionally substituted alkoxy, optionally substituted aralkoxy, optionally substituted acyl, nitro, carboxylic acid, carboxylic acid derivative, or an optionally substituted five, six- or seven-membered heterocyclic ring containing one, two or three nitrogen heteroatoms and being attached to the quinoline ring through one of the nitrogen atoms; R<SP>2</SP> is hydrogen, halogen, optionally substituted alkyl, optionally substituted aralkyl, optionally substituted aryl, optionally substituted amino, nitro, hydroxyl, optionally substituted alkoxy, optionally substituted aralkoxy, or optionally substituted aryloxy; R<SP>3</SP> is hydrogen, halogen, optionally substituted alkyl, optionally substituted aralkyl, optionally substituted aryl, optionally substituted amino, hydroxyl, optionally substituted alkoxy or optionally substituted aryloxy; or R<SP>2</SP> and R<SP>3</SP>, together with the 5,6-, 6,7- or 7,8-side of quinoline ring, form an optionally substituted, five-, six- or sevenmembered ring optionally containing one or two heteroatoms selected from oxygen, sulphur and nitrogen; and when n=0, and R<SP>3</SP> is attached to the 8-position of the quinoline ring, R<SP>3</SP> and R may form together an optionally substituted -(CH 2 ) m - chain, wherein m is 2, 3 or 4; X is oxygen or sulphur; and R<SP>4</SP> is hydroxyl or mercapto, comprises subjecting to hydrolysis or thiolysis a compound having the general Formula II wherein n, R, R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP> and X are as defined above; R<SP>5</SP> is hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, or optionally substituted cycloalkyl or cycloalkylalkyl; R<SP>6</SP> is hydrogen, optionally substituted alkyl, optionally substituted aryl, or optionally substituted aralkyl; Y is an aromatic heterocyclic ring containing a tertiary nitrogen, and is attached through the nitrogen, or Y is a trialkylamino group; and Z is an anion.
GB23285/76A 1975-06-06 1976-06-04 Preparation of quinoline derivatives Expired GB1502405A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU75CI00001585A HU170951B (en) 1975-06-06 1975-06-06 New process for preparing 3-quinolinecarboxylic acids

Publications (1)

Publication Number Publication Date
GB1502405A true GB1502405A (en) 1978-03-01

Family

ID=10994570

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23285/76A Expired GB1502405A (en) 1975-06-06 1976-06-04 Preparation of quinoline derivatives

Country Status (8)

Country Link
JP (1) JPS51146476A (en)
DK (1) DK247976A (en)
ES (1) ES448619A1 (en)
FI (1) FI761583A (en)
GB (1) GB1502405A (en)
HU (1) HU170951B (en)
NO (1) NO761926L (en)
SE (1) SE7606308L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855292A (en) * 1986-02-25 1989-08-08 Otsuka Pharmaceutical Company, Limited 1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5540616A (en) * 1978-09-14 1980-03-22 Otsuka Pharmaceut Co Ltd Preparation of benzo-hetero-compound
JPS58105965A (en) * 1981-12-15 1983-06-24 Nippon Shinyaku Co Ltd Substituted quinolinecarboxylic acid derivative
JPS61143363A (en) * 1984-12-17 1986-07-01 Kyorin Pharmaceut Co Ltd Method for producing quinolone carboxylic acid derivatives
JPS61143364A (en) * 1984-12-17 1986-07-01 Kyorin Pharmaceut Co Ltd Method for producing quinolone carboxylic acid derivatives
JPS6483068A (en) * 1987-09-25 1989-03-28 Otsuka Pharma Co Ltd Production of benzo-heterocyclic compound
DE69528160T2 (en) * 1994-03-01 2003-02-06 Chemipro Kasei Kaisha, Ltd. METHOD FOR PRODUCING 5,7 DICHLOR-4-HYDROXYCHINOLINE

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855292A (en) * 1986-02-25 1989-08-08 Otsuka Pharmaceutical Company, Limited 1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives
US4874764A (en) * 1986-02-25 1989-10-17 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US4880806A (en) * 1986-02-25 1989-11-14 Otsuka Pharmaceutical Company, Limited 1-Cyclopropyl-6-fluoro-7-piperazinyl-1,4-Dihydro-4-oxo-quinoline-3-carboxylic acid derivatives
US4935420A (en) * 1986-02-25 1990-06-19 Otsuka Pharmaceutical Company, Ltd. Benzoheterocyclic compounds

Also Published As

Publication number Publication date
NO761926L (en) 1976-12-07
JPS51146476A (en) 1976-12-16
FI761583A (en) 1976-12-07
DK247976A (en) 1976-12-07
HU170951B (en) 1977-10-28
ES448619A1 (en) 1977-07-01
SE7606308L (en) 1976-12-07

Similar Documents

Publication Publication Date Title
MY100574A (en) 5-substituted-2-cyclopropyl-6, 8-difluoroquinoline derivatives and processes for preparation thereof
KR850001171A (en) Method for preparing quinoline compound
ES8202792A1 (en) and phenoxy-amino acids and phenoxy-peptide esters suitable as substrates therefor, process for their production and their use in producing the agents.
TW430656B (en) Quinolinone derivative, method for preparing the same, and anti-allergic agent
PT65019A (en) PHENYLALKANCARBONE ACID DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
HUT42056A (en) Process for preparing substituted derivatives of p,p&#39;-methylene-bis-anilines
GB1502405A (en) Preparation of quinoline derivatives
ES8201582A1 (en) Triazolopyridazine derivatives, process and intermediates for their preparation and medicaments containing them.
ES8604543A1 (en) Piperazine derivatives with anticholinergic and/or antihistaminic activity
KR840006482A (en) Method for preparing [3,4-b] pyridine derivative with dihydropyrazolo
ES417890A1 (en) Penicillanic acid derivatives
RO92245B (en) Process for preparing some 1,6-naphtiridine derivatives
ATE50247T1 (en) PRODUCTION OF SUBSTITUTED AND NON-SUBSTITUTED 2-CARBAMOYL DERIVATIVES OF NICOTINE ACID AND QUINOLINE-3-CARBOXYL ACID.
GB1505427A (en) Quinoline derivatives
NO882958D0 (en) PROCEDURE FOR PREPARING 2-ARYLOXYPROPIONIC ACID.
JPS5430183A (en) 3,4-dihydrocarbostyril derivative
GB1447329A (en) Preparation of sulphonyl-benzamide derivatives
GB1449524A (en) Preparation of salicylamide derivatives
GB1030022A (en) Process for the production of isoquinoline derivatives
ES448933A1 (en) Process for preparation of novel carboxylic acid derivatives
ES448932A1 (en) Process for preparation of novel carboxylic acid dervatives
GB1340512A (en) Production of esters of chromone-2-carboxylic acids
JPS5418832A (en) Preparation of hetericyclic dyes
ES412484A1 (en) Procedure for the preparation of carbostirilic derivatives. (Machine-translation by Google Translate, not legally binding)
ES454644A1 (en) Process for preparing substituted phenoxyaliphatic acids

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
746 Register noted 'licences of right' (sect. 46/1977)
PCNP Patent ceased through non-payment of renewal fee