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GB1496231A - Chemical products - Google Patents

Chemical products

Info

Publication number
GB1496231A
GB1496231A GB29879/75A GB2987975A GB1496231A GB 1496231 A GB1496231 A GB 1496231A GB 29879/75 A GB29879/75 A GB 29879/75A GB 2987975 A GB2987975 A GB 2987975A GB 1496231 A GB1496231 A GB 1496231A
Authority
GB
United Kingdom
Prior art keywords
difluorophenyl
formula
compound
stage
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29879/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/571,165 external-priority patent/US3992459A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1496231A publication Critical patent/GB1496231A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

5-(2,4-Difluorophenyl)-salicylic acid of the formula I <IMAGE> is obtained when a) a 4-(2,4-difluorophenyl)-oxo-C1-C4-alkyl compound (II) is oxidised to a corresponding ester, the latter is hydrolysed, in stage b), to give 4-(2,4-difluorophenyl)-phenol and finally, in stage c), the carboxyl group is introduced into the ring carrying the hydroxyl group. The compound of the formula (II) is prepared by reacting a 2,4-difluorobenzenediazonium salt with benzene or a benzenediazonium salt with 2,4-difluorobenzene and acylating the resulting 2,4-difluorobiphenyl. The compound of formula I can be used as an anti-inflammatory, antipyretic and analgesic agent.
GB29879/75A 1974-07-22 1975-07-16 Chemical products Expired GB1496231A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49062074A 1974-07-22 1974-07-22
US56720175A 1975-04-16 1975-04-16
US05/571,165 US3992459A (en) 1975-05-01 1975-05-01 Preparation of biphenyl compounds

Publications (1)

Publication Number Publication Date
GB1496231A true GB1496231A (en) 1977-12-30

Family

ID=27413871

Family Applications (2)

Application Number Title Priority Date Filing Date
GB29879/75A Expired GB1496231A (en) 1974-07-22 1975-07-16 Chemical products
GB6938/77A Expired GB1496232A (en) 1974-07-22 1975-07-16 Preparation of 2,4-difluorobiphenyl

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB6938/77A Expired GB1496232A (en) 1974-07-22 1975-07-16 Preparation of 2,4-difluorobiphenyl

Country Status (11)

Country Link
JP (1) JPS5134135A (en)
CH (1) CH615146A5 (en)
DE (1) DE2532559C3 (en)
DK (1) DK145643C (en)
FR (1) FR2288729A1 (en)
GB (2) GB1496231A (en)
IE (1) IE41582B1 (en)
LU (1) LU73032A1 (en)
NL (1) NL188689C (en)
NO (1) NO143874C (en)
SE (1) SE428560B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216340A (en) * 1979-05-02 1980-08-05 Merck & Co., Inc. Preparation of 5-(2,4-difluorophenyl)salicylic acid and derivatives

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1133963B (en) * 1980-10-21 1986-07-24 D & D Srl PYRIDOXY DERIVATIVES FOR THERAPEUTIC ACTIVITIES, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
US4482502A (en) * 1983-04-25 1984-11-13 Ethyl Corporation Preparation of biaryl compounds
JPH0582493U (en) * 1992-04-06 1993-11-09 株式会社エースプレミアム Traveling toys

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO120372B (en) * 1966-09-08 1970-10-12 Merck & Co Ltd
US3714226A (en) * 1970-06-09 1973-01-30 Merck & Co Inc Phenyl benzoic acid compounds
GB1359987A (en) * 1970-10-12 1974-07-17 Boots Co Ltd 2-substituted biphenylyl propionic acids
JPS4916419A (en) * 1972-05-31 1974-02-13

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216340A (en) * 1979-05-02 1980-08-05 Merck & Co., Inc. Preparation of 5-(2,4-difluorophenyl)salicylic acid and derivatives

Also Published As

Publication number Publication date
NO752482L (en) 1976-01-23
JPS5134135A (en) 1976-03-23
NO143874C (en) 1981-04-29
SE428560B (en) 1983-07-11
NL188689B (en) 1992-04-01
DK145643B (en) 1983-01-10
CH615146A5 (en) 1980-01-15
FR2288729B1 (en) 1977-12-09
GB1496232A (en) 1977-12-30
NL7508127A (en) 1976-01-26
FR2288729A1 (en) 1976-05-21
DE2532559A1 (en) 1976-02-05
IE41582B1 (en) 1980-02-13
IE41582L (en) 1976-01-22
SE7507764L (en) 1976-01-23
LU73032A1 (en) 1976-07-01
NO143874B (en) 1981-01-19
DE2532559C3 (en) 1979-10-04
DK310075A (en) 1976-01-23
DK145643C (en) 1983-07-11
NL188689C (en) 1992-09-01
JPS569496B2 (en) 1981-03-02
DE2532559B2 (en) 1979-02-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years

Effective date: 19950715