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GB1496156A - 2-chloropropionic acid and its derivatives - Google Patents

2-chloropropionic acid and its derivatives

Info

Publication number
GB1496156A
GB1496156A GB5356674A GB5356674A GB1496156A GB 1496156 A GB1496156 A GB 1496156A GB 5356674 A GB5356674 A GB 5356674A GB 5356674 A GB5356674 A GB 5356674A GB 1496156 A GB1496156 A GB 1496156A
Authority
GB
United Kingdom
Prior art keywords
aniline
halo
compound
trifluoromethylphenoxy
phenoxyethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5356674A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP49044634A external-priority patent/JPS5742052B2/ja
Priority claimed from JP11655974A external-priority patent/JPS5143738A/en
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of GB1496156A publication Critical patent/GB1496156A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1496156 3-Aryl-2-halo-propionic acid derivatives TAKEDA YAKUHIN KOGYO KK 11 Dec 1974 [19 April 1974 9 Oct 1974] 53566/74 Heading C2C Novel compounds I (in which R<SP>1</SP> is H, 1-5C alkyl, halo, OH, CF 3 or 1-4C alkoxy; R<SP>2</SP> and R<SP>3</SP> are H or 1-5C alkyl; X is halo; Y is -O-, 1-6C alkylenethio, 1-6C alkyleneoxy, or 1-6C alkylenedioxy; Z is COOH or a group convertible thereto (e.g. ester, nitrile, amide or aldehyde groups) and n is 1 or 2) and pharmaceutically acceptable salts thereof are prepared by reaction of a compound II (in which R<SP>4</SP> is as R<SP>1</SP> or is -N 2 <SP>+</SP>X<SP>-</SP>) with a compound III Intermediates isolated are 4-(2-phenoxyethyl)- acetanilide; 4-(2-phenoxyethyl)aniline hydrochloride; 4- (1 -phenyl-2-methylpropyloxy)- aniline hydrochloride; 4-acetamidophenoxy-4- chlorophenyl methane; 4-(4-chlorobenzyloxy)- aniline; 4 - (4 - chlorophenoxymethyl)aniline; 4 - (3 - trifluoromethylphenoxy)nitrobenzene and 4 - (3 - trifluoromethylphenoxy)aniline, all of which are prepared by known methods. Pharmaceutical compositions having hypolipidemic, hypoglycemic and other activities comprise a compound I or a suitable salt together with a carrier or diluent.
GB5356674A 1974-04-19 1974-12-11 2-chloropropionic acid and its derivatives Expired GB1496156A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP49044634A JPS5742052B2 (en) 1974-04-19 1974-04-19
JP11655974A JPS5143738A (en) 1974-10-09 1974-10-09 Arufua harogenokarubonsankagobutsuno seizoho

Publications (1)

Publication Number Publication Date
GB1496156A true GB1496156A (en) 1977-12-30

Family

ID=26384582

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5356674A Expired GB1496156A (en) 1974-04-19 1974-12-11 2-chloropropionic acid and its derivatives

Country Status (3)

Country Link
AT (1) AT341505B (en)
GB (1) GB1496156A (en)
HU (1) HU170228B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0606514A1 (en) * 1993-01-15 1994-07-20 Rolan Wu Microstrip element phase-shift array antenna
WO2004113282A1 (en) * 2003-06-18 2004-12-29 Astrazeneca Ab Therapeutic agents
US7323496B2 (en) 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0606514A1 (en) * 1993-01-15 1994-07-20 Rolan Wu Microstrip element phase-shift array antenna
US7323496B2 (en) 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
WO2004113282A1 (en) * 2003-06-18 2004-12-29 Astrazeneca Ab Therapeutic agents

Also Published As

Publication number Publication date
ATA988174A (en) 1977-06-15
HU170228B (en) 1977-04-28
AT341505B (en) 1978-02-10

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee