GB1490917A - Antibiotics mc916-c and -b substances inhibiting the growth of leukemia cells and the production of these new substances - Google Patents
Antibiotics mc916-c and -b substances inhibiting the growth of leukemia cells and the production of these new substancesInfo
- Publication number
- GB1490917A GB1490917A GB9160/75A GB916075A GB1490917A GB 1490917 A GB1490917 A GB 1490917A GB 9160/75 A GB9160/75 A GB 9160/75A GB 916075 A GB916075 A GB 916075A GB 1490917 A GB1490917 A GB 1490917A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substance
- mc916b
- mc916a
- substances
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000126 substance Substances 0.000 title abstract 13
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 208000032839 leukemia Diseases 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 6
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 238000000921 elemental analysis Methods 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 241000786363 Rhampholeon spectrum Species 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 abstract 2
- 238000005187 foaming Methods 0.000 abstract 2
- 239000000155 melt Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 239000000741 silica gel Substances 0.000 abstract 2
- 229910002027 silica gel Inorganic materials 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 238000001228 spectrum Methods 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- PKDBCJSWQUOKDO-UHFFFAOYSA-M 2,3,5-triphenyltetrazolium chloride Chemical compound [Cl-].C1=CC=CC=C1C(N=[N+]1C=2C=CC=CC=2)=NN1C1=CC=CC=C1 PKDBCJSWQUOKDO-UHFFFAOYSA-M 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- 208000007093 Leukemia L1210 Diseases 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- FWMBCNGLMRSLPH-UHFFFAOYSA-N O.OC=O.CC(O)=O Chemical compound O.OC=O.CC(O)=O FWMBCNGLMRSLPH-UHFFFAOYSA-N 0.000 abstract 1
- 241000187180 Streptomyces sp. Species 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008151 electrolyte solution Substances 0.000 abstract 1
- 238000001962 electrophoresis Methods 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Alternative & Traditional Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
1490917 Antibiotic ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI 5 March 1975 [12 March 1974] 9160/75 Heading C2A The invention is directed to substance MC916 having an activity inhibitory to the growth of leukemia L-1210 cells in mice and a low antibacterial activity, said substance having an acidic function, being soluble in methanol, ethanol, propanol, chloroform and dioxan and slightly soluble in water but sparingly soluble in ethyl ether and n-hexane, being positive to the Rydon-Smith reaction and the red tetrazolium reaction, weakly positive to the ninhydrin reaction but negative to the Ehrlich reaction and the Sakaguchi reaction, giving essentially C, H, N and O on elemental analysis; exhibiting a relative mobility of said substance to alanine (1À0) of 0À17 on high-voltage filter paper electrophoresis (3500 volts, 35 minutes) using formic acid-acetic acid-water (25 : 75 : 900) as an electrolyte solution; said substance being at least one member selected from the group consisting of MC916A and MC916B. Substance MC916A is characterized by having an elemental analysis C 57À46%, H 5À76%, N 9À84%, O (balance), a M.Wt. of 250 to 300 by the Barger-Akiya method, having an I.R. spectrum corresponding to that in Fig. 1 (not shown), U.V. spectra corresponding to those in Fig. 3 (not shown) and giving an Rf value of 0À57 in t.l.c. on silica gel with chloroform-methanol (10 : 1 by volume) as the developing solvent. Substances MC916B is characterized by having an elemental analysis C 57À00%, H 5À58%, N 9À75%, O (balance), a M.Wt. of 250 to 300 as measured by the Barger-Akiya method, having an I.R. spectrum corresponding to that in Fig. 2 (not shown), U.V. spectra corresponding to those in Fig. 4 (not shown), and giving an Rf value of 0À50 in t.l.c. on silica gel with chloroform-methanol (10 : 1 by volume) as a developing solvent. Substance MC916A is in the form of a colourless powder having no definite M.Pt., which melts gradually near 105‹ C. and decomposes at 110-122‹ C. with foaming and exhibits a specific optical rotation [α] D <SP>22</SP>= + 154 degrees (c 0À59, ethanol). Substance MC916B is in the form of a colourless powder having no definite M.Pt., which decomposes at 139‹ C. with foaming and melts completely at 163‹ C. and which exhibits a specific optical rotation [α] D <SP>22</SP>= + 152 degrees (c 0À203, ethanol). Substances MC916A and MC916B may be prepared by cultivating an MC916 substanceproducing strain of the genus Streptomyces sp. MC916C4, ATCC 31123, under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen, and recovering substances MC916A and MC916B from the culture. MC916A and/or MC916B substance may, in an amount to reduce the affection by leukemia in vivo be admixed with a suitable carrier to form a pharmaceutical composition.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP49027674A JPS50121495A (en) | 1974-03-12 | 1974-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1490917A true GB1490917A (en) | 1977-11-02 |
Family
ID=12227487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9160/75A Expired GB1490917A (en) | 1974-03-12 | 1975-03-05 | Antibiotics mc916-c and -b substances inhibiting the growth of leukemia cells and the production of these new substances |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS50121495A (en) |
| CA (1) | CA1056747A (en) |
| DE (1) | DE2510568A1 (en) |
| FR (1) | FR2263783B1 (en) |
| GB (1) | GB1490917A (en) |
-
1974
- 1974-03-12 JP JP49027674A patent/JPS50121495A/ja active Pending
-
1975
- 1975-03-05 GB GB9160/75A patent/GB1490917A/en not_active Expired
- 1975-03-11 DE DE19752510568 patent/DE2510568A1/en active Pending
- 1975-03-11 CA CA221,848A patent/CA1056747A/en not_active Expired
- 1975-03-12 FR FR7507700A patent/FR2263783B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2510568A1 (en) | 1975-09-18 |
| JPS50121495A (en) | 1975-09-23 |
| FR2263783B1 (en) | 1978-07-28 |
| CA1056747A (en) | 1979-06-19 |
| FR2263783A1 (en) | 1975-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |