GB1482785A - Method of preparing a homogeneous lyophilised composition - Google Patents
Method of preparing a homogeneous lyophilised compositionInfo
- Publication number
- GB1482785A GB1482785A GB47058/74A GB4705874A GB1482785A GB 1482785 A GB1482785 A GB 1482785A GB 47058/74 A GB47058/74 A GB 47058/74A GB 4705874 A GB4705874 A GB 4705874A GB 1482785 A GB1482785 A GB 1482785A
- Authority
- GB
- United Kingdom
- Prior art keywords
- droplets
- liquid
- substance
- lyophilised
- homogeneous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000007788 liquid Substances 0.000 abstract 3
- 239000001828 Gelatine Substances 0.000 abstract 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 229920000159 gelatin Polymers 0.000 abstract 2
- 235000019322 gelatine Nutrition 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000003507 refrigerant Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 108010001478 Bacitracin Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 108010093965 Polymyxin B Proteins 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 229960003071 bacitracin Drugs 0.000 abstract 1
- 229930184125 bacitracin Natural products 0.000 abstract 1
- CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 229940088623 biologically active substance Drugs 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 abstract 1
- 229960001076 chlorpromazine Drugs 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- UMNKXPULIDJLSU-UHFFFAOYSA-N dichlorofluoromethane Chemical compound FC(Cl)Cl UMNKXPULIDJLSU-UHFFFAOYSA-N 0.000 abstract 1
- 229940099364 dichlorofluoromethane Drugs 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229920000024 polymyxin B Polymers 0.000 abstract 1
- 229960005266 polymyxin b Drugs 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 229960003604 testosterone Drugs 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 229940125725 tranquilizer Drugs 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
- F26B5/065—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing the product to be freeze-dried being sprayed, dispersed or pulverised
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/16—Physical preservation processes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/16—Physical preservation processes
- A01N1/162—Temperature processes, e.g. following predefined temperature changes over time
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1482785 Lyophilised products E I DU PONT DE NEMOURS & CO 30 Oct 1974 47058/74 Addition to 1316522 Heading A5B An homogeneous lyophilised biologically active substance is prepared by a method which comprises (a) spraying a solution or colloidal suspension of the substance in a liquid, which will both freeze and vaporise from the solid state at a temperature at which the biological activity of the substance is not destroyed, in the form of droplets into a stirred boiling fluorocarbon refrigerant at below -20C to freeze the droplets, (b) subjecting the frozen droplets to a vacuum at a temperature such that substantially all the frozen liquid sublimes from the droplets; and (c) allowing the particles to come to room temperature and pressure. The liquid may be organio or water. The active substance may be a vitamin, hormone, tranquilizer, antibiotic, an enzyme, gelatine or other protein. The products of the Examples are bacitracin, polymyxin B, tetracycline, chlorpromazine testosterone, cholesterol and gelatine. The refrigerant may be dichlorofluoromethane. The product is in the form of spheres of diameter not greater than 1 mm and a "standard dissolution time" (defined) not exceeding 2 minutes, at least 90% of the particles being pores.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB47058/74A GB1482785A (en) | 1974-10-30 | 1974-10-30 | Method of preparing a homogeneous lyophilised composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB47058/74A GB1482785A (en) | 1974-10-30 | 1974-10-30 | Method of preparing a homogeneous lyophilised composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1482785A true GB1482785A (en) | 1977-08-17 |
Family
ID=10443553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB47058/74A Expired GB1482785A (en) | 1974-10-30 | 1974-10-30 | Method of preparing a homogeneous lyophilised composition |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1482785A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2133983A (en) * | 1983-01-25 | 1984-08-08 | Lafon Labor | Method for preparing galenic formulations particularly for pharmaceutical, dietary, cosmetic and diagnostic uses |
| EP0475409A2 (en) * | 1990-09-12 | 1992-03-18 | Lifecell Corporation | Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions |
| US5336616A (en) * | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
| WO2006008006A1 (en) * | 2004-07-23 | 2006-01-26 | Bayer Technology Services Gmbh | Sterile freezing, drying, storing, assaying and filling process (sfd-saf process) (pellet freeze-drying process for parenteral biopharmaceuticals) |
| US7358284B2 (en) | 1998-06-19 | 2008-04-15 | Lifecell Corporation | Particulate acellular tissue matrix |
| US8067149B2 (en) | 1990-09-12 | 2011-11-29 | Lifecell Corporation | Acellular dermal matrix and method of use thereof for grafting |
-
1974
- 1974-10-30 GB GB47058/74A patent/GB1482785A/en not_active Expired
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2133983A (en) * | 1983-01-25 | 1984-08-08 | Lafon Labor | Method for preparing galenic formulations particularly for pharmaceutical, dietary, cosmetic and diagnostic uses |
| EP0475409A2 (en) * | 1990-09-12 | 1992-03-18 | Lifecell Corporation | Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions |
| EP0475409A3 (en) * | 1990-09-12 | 1993-09-01 | Lifecell Corporation | Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions |
| US5336616A (en) * | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
| US5364756A (en) * | 1990-09-12 | 1994-11-15 | Lifecell | Method of cryopreserving a suspension of biological material |
| US5780295A (en) * | 1990-09-12 | 1998-07-14 | Life Cell Corporation | Apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions |
| US6194136B1 (en) | 1990-09-12 | 2001-02-27 | Lifecell Corporation | Cryoprotective solutions comprising DMSO, PG, 2,3-butanediol,raffinose and PVP |
| US8067149B2 (en) | 1990-09-12 | 2011-11-29 | Lifecell Corporation | Acellular dermal matrix and method of use thereof for grafting |
| US7358284B2 (en) | 1998-06-19 | 2008-04-15 | Lifecell Corporation | Particulate acellular tissue matrix |
| WO2006008006A1 (en) * | 2004-07-23 | 2006-01-26 | Bayer Technology Services Gmbh | Sterile freezing, drying, storing, assaying and filling process (sfd-saf process) (pellet freeze-drying process for parenteral biopharmaceuticals) |
| US7836606B2 (en) | 2004-07-23 | 2010-11-23 | Bayer Technology Services Gmbh | Sterile freezing, drying, storing, assaying and filling process |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] |