[go: up one dir, main page]

GB1479333A - Aniline derivatives - Google Patents

Aniline derivatives

Info

Publication number
GB1479333A
GB1479333A GB4875574A GB4875574A GB1479333A GB 1479333 A GB1479333 A GB 1479333A GB 4875574 A GB4875574 A GB 4875574A GB 4875574 A GB4875574 A GB 4875574A GB 1479333 A GB1479333 A GB 1479333A
Authority
GB
United Kingdom
Prior art keywords
alkyl
hydrogen
pharmaceutically acceptable
anilines
nov
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4875574A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1479333A publication Critical patent/GB1479333A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C07C65/26—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

1479333 Anilines UPJOHN CO 11 Nov 1974 [16 Nov 1973 19 Sept 1974] 48755/74 Heading C2C [Also in Division C5] Novel anilines of the general formula wherein X is O, S, CH 2 , N-(C 1-5 alkyl) or N- (C 1-5 acyl); R 1 is hydrogen, C 1-8 alkyl, (CH2) n - phenyl, C 2-6 alkynyl, 2-pyrrolidinoethyl, (CH2) n - 0-phenyl, (CH 2 ) n -NR 6 R 7 or (CH 2 ) n OH, n is 1, 2 or 3, each of R 6 and R 7 is C 1-6 alkyl ; R 2 is hydrogen, C 1-6 alkyl, C 1-6 aliphatic acyl or C 1-6 alkoxy-carbonyl; or R 1 R 2 N is N(CH 2 ) m in which m is 4-6, N-R 5 -piperazino (R 5 is H or C 1-6 alkyl), morpholino or thiamorpholino; R 3 is hydrogen, halogen, 3-methyl, 2,6- or 3,5- dimethyl, -CHO, -CH 2 OH, -CH(CH 3 )OH, 3-NR 1 R 2 or -CH 2 SCH 3 and R 4 is a bridged polycyclic hydrocarbon attached through a tertiary carbon atom, and pharmaceutically acceptable acid addition salts thereof are prepared by conventional methods, described under Reaction Schemes (1)-(21) in the Specification. Pharmaceutical compositions having hypolipidemic and hypocholesteremic activity comprise, as active ingredient, an aniline of the general formula above or a pharmaceutically acceptable acid addition salt thereof, together with a pharmaceutically acceptable carrier.
GB4875574A 1973-11-16 1974-11-11 Aniline derivatives Expired GB1479333A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41640273A 1973-11-16 1973-11-16
US50746274A 1974-09-19 1974-09-19

Publications (1)

Publication Number Publication Date
GB1479333A true GB1479333A (en) 1977-07-13

Family

ID=27023340

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4875574A Expired GB1479333A (en) 1973-11-16 1974-11-11 Aniline derivatives

Country Status (6)

Country Link
JP (1) JPS50105646A (en)
CA (1) CA1007225A (en)
DE (1) DE2450812A1 (en)
FR (1) FR2251316B1 (en)
GB (1) GB1479333A (en)
NL (1) NL7414909A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2086377B (en) * 1977-12-29 1982-11-10 Yamanouchi Pharma Co Ltd Cyclic aminophenyl ether compounds
FR2698355B1 (en) * 1992-11-24 1995-01-20 Adir New 1-phenylbicyclo [2.2.2] octane derivatives, process for their preparation and pharmaceutical compositions containing them.

Also Published As

Publication number Publication date
FR2251316B1 (en) 1980-01-11
JPS50105646A (en) 1975-08-20
DE2450812A1 (en) 1975-05-22
AU7492074A (en) 1976-05-06
CA1007225A (en) 1977-03-22
FR2251316A1 (en) 1975-06-13
NL7414909A (en) 1975-05-21

Similar Documents

Publication Publication Date Title
DE3061175D1 (en) Glucosamine-peptide derivatives, their production and use
GB1459571A (en) Thiophene-2-sulphonamide derivatives and their use as therapeutic agents sheet orienting apparatus
ATE36859T1 (en) 4'-DEMETHYL-4-EPIPODOPHYLLOTOXIN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.
GB1492457A (en) 1,2-alkylene-4-substituted urazole derivative
GB1301431A (en)
ES442845A2 (en) Novel derivatives of N-(3,4,5-trimethoxy cinnamoyl)piperazine and the process for preparing them
GB1369248A (en) Amides the preparation thereof and their use in pharmacjeutical compositions
GB1461032A (en) Erthromycylamine derivatives
GB1479333A (en) Aniline derivatives
GB1482099A (en) Sulphonamido derivatives
GB1512648A (en) Cyclic ether antibiotic derivatives
GB1230219A (en)
GB1525351A (en) Benzazepine derivatives and their acid addition salts processes for preparing them and pharmaceutical compositions containing them
ES453544A1 (en) Preparation of ethylamine derivatives
GB1449802A (en) Piperazine derivatives and compositions containing them for treating parkinsons disease
ES451067A1 (en) Psychotropic 2-trifluoromethyl-10-{8 3-(3-hydroxy-pyrrolidino)-propyl{9 -phenothiazine compounds
GB1413454A (en) 4-alkoxyalkyleneoxy-5-benzylpyrimidines their preparation and pharmaceutical compositions thereof
GB1514225A (en) Paracetamol derivatives
GB1454666A (en) Pyrido 2,3-d- pyrimidinethiones
GB1449070A (en) Aminotetralins and use in inducing anesthesia
GB1460811A (en) Bis-benzamido-benzoic acid derivatives
ES556048A0 (en) A PROCEDURE FOR THE PREPARATION OF A THIAZOLIDINE DERIVATIVE.
IE40561B1 (en) Alkylmercaptomethylquinoxaline 1,4-dioxides and derivatives thereof
GB1466411A (en) Sulphur-containing hydroxy aliphatic compounds
GB1529551A (en) Benzofuran derivatives

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee