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GB1475694A - Amide derivatives of nicotinic acid - Google Patents

Amide derivatives of nicotinic acid

Info

Publication number
GB1475694A
GB1475694A GB3456673A GB3456673A GB1475694A GB 1475694 A GB1475694 A GB 1475694A GB 3456673 A GB3456673 A GB 3456673A GB 3456673 A GB3456673 A GB 3456673A GB 1475694 A GB1475694 A GB 1475694A
Authority
GB
United Kingdom
Prior art keywords
optionally substituted
nicotinic acid
amide derivatives
branched aliphatic
aliphatic chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3456673A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of GB1475694A publication Critical patent/GB1475694A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/83—Thioacids; Thioesters; Thioamides; Thioimides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

1475694 Amide derivatives of nicotinic acid SIGMA - TAU INDUSTRIE FARMACEU. TICHE RIUNITE SpA 18 April 1975 [19 Jan 1974 18 March 1974] 34566/74 and 11970/74 Heading C2C Novel compounds (I) (including salts thereof) where R is H, or an optionally substituted alkyl or alkylaryl radical; R 1 is an optionally substituted linear or branched aliphatic chain; or an optionally substituted 3- to 7-membered aromatic or heterocyclic ring; R 2 is H, or a radical of Formula (II) or (III) with the proviso that when R 1 is an optionally substituted linear or branched aliphatic chain R 2 is not H, are made by reacting nicotinoyl chloride with R-NH-R 1 -S-R 2 . The disulphide corresponding to nicotinic acid #-mercapto-ethylamide is isolated as a byproduct. Pharmaceutical preparations suitable for treating lesions of the hepatopathies and for decreasing arterial blood pressure contain (I) as active ingredient. Administration is orally or parenterally.
GB3456673A 1975-04-18 1973-07-19 Amide derivatives of nicotinic acid Expired GB1475694A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1197074 1975-04-18

Publications (1)

Publication Number Publication Date
GB1475694A true GB1475694A (en) 1977-06-01

Family

ID=9996020

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3456673A Expired GB1475694A (en) 1975-04-18 1973-07-19 Amide derivatives of nicotinic acid

Country Status (1)

Country Link
GB (1) GB1475694A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172545A1 (en) * 1984-08-20 1986-02-26 Nippon Kayaku Co., Ltd. 3-or 4-pyridinecarboxamide-derivates and their use as bactericides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172545A1 (en) * 1984-08-20 1986-02-26 Nippon Kayaku Co., Ltd. 3-or 4-pyridinecarboxamide-derivates and their use as bactericides

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee