[go: up one dir, main page]

GB1474906A - Pyrolidine derivatives - Google Patents

Pyrolidine derivatives

Info

Publication number
GB1474906A
GB1474906A GB4539473A GB4539473A GB1474906A GB 1474906 A GB1474906 A GB 1474906A GB 4539473 A GB4539473 A GB 4539473A GB 4539473 A GB4539473 A GB 4539473A GB 1474906 A GB1474906 A GB 1474906A
Authority
GB
United Kingdom
Prior art keywords
formula
diphenylcyclopropyl
sept
pharmaceutically acceptable
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4539473A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hexachimie SA
Original Assignee
Hexachimie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hexachimie SA filed Critical Hexachimie SA
Priority to GB4539473A priority Critical patent/GB1474906A/en
Priority to FR7430478A priority patent/FR2245362B1/fr
Publication of GB1474906A publication Critical patent/GB1474906A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pyrrole Compounds (AREA)

Abstract

1474906 Diphenyl cyclopropyl pyrrolidines and their pharmaceutical compositions HEXACHIMIE 27 Sept 1974 [27 Sept 1973] 45394/73 Heading C2C The invention comprises compounds of the Formula I wherein R, R<SP>1</SP> and R<SP>11</SP> are independently hydrogen halogen atoms or C 1-4 alkyl, C 1-4 alkoxy, hydroxy or trihalomethyl groups and their pharmaceutically acceptable acid addition salts, which may be prepared by hydrogenation of nitropentanones of general Formula II Diphenyl cyclopropyl styryl ketones are prepared by reacting a benzaldehyde having substituents R, R<SP>1</SP> and R<SP>11</SP> as defined above with diphenylcyclopropyl methyl ketone in the presence of a base under the conditions of the Clausin-Schmidt condensation, and are further reacted with nitroethane in the presence of a base and in an organic solvent using the conditions of the Michael addition to obtain the corresponding 1 - (2<SP>1</SP>,2<SP>1</SP> - diphenylcyclopropyl)- 3 - (substituted phenyl) - 4 - nitropentanone. Pharmaceutical compositions having sedative and antiarrythmic properties for oral or rectal administration comprise a compound of Formula I or an acid addition salt thereof and a pharmaceutically acceptable carrier or diluent.
GB4539473A 1973-09-27 1973-09-27 Pyrolidine derivatives Expired GB1474906A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB4539473A GB1474906A (en) 1973-09-27 1973-09-27 Pyrolidine derivatives
FR7430478A FR2245362B1 (en) 1973-09-27 1974-09-09

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4539473A GB1474906A (en) 1973-09-27 1973-09-27 Pyrolidine derivatives

Publications (1)

Publication Number Publication Date
GB1474906A true GB1474906A (en) 1977-05-25

Family

ID=10437061

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4539473A Expired GB1474906A (en) 1973-09-27 1973-09-27 Pyrolidine derivatives

Country Status (2)

Country Link
FR (1) FR2245362B1 (en)
GB (1) GB1474906A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115433331A (en) * 2022-08-12 2022-12-06 南昌大学 Preparation method of an olefin-linked covalent organic framework and its photocatalytic application

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115433331A (en) * 2022-08-12 2022-12-06 南昌大学 Preparation method of an olefin-linked covalent organic framework and its photocatalytic application
CN115433331B (en) * 2022-08-12 2023-10-31 南昌大学 Preparation method of an olefin-linked covalent organic framework and its photocatalytic application

Also Published As

Publication number Publication date
FR2245362A1 (en) 1975-04-25
FR2245362B1 (en) 1977-11-04

Similar Documents

Publication Publication Date Title
KR880011135A (en) Novel thiazole derivatives acting on the cholinergic system, preparations thereof, and pharmaceutical compositions
GB1313689A (en) Quinoxaline derivatives
ES373853A2 (en) Derivatives of 4-hydroxy coumarine
GB1069797A (en) ª‡-aminoketone derivatives
ATE18226T1 (en) PYRROLO(2,3-D)CARBAZOL DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR THERAPEUTIC USE.
GB1474906A (en) Pyrolidine derivatives
ES391633A1 (en) 2,2,-diaryl-4-4-aryl-4-hydroxy-piperidino butyramides
GB1432816A (en) Pharmaceutical antimycotic compositions medicaments and method
GB1140188A (en) Pyrroline derivatives
GB1391584A (en) N-substituted anthranilic acids
Norris et al. 2-Guanidino-4 (5)-p-chlorophenylimidazoles
GB1474907A (en) Pyrolidine derivatives
SU845778A3 (en) Method of preparing 5-puenyl-1h-banzazepins or their salts
GB1181322A (en) Piperazine Derivatives and processes for preparing the same
GB1061946A (en) Novel dibenzocycloheptene derivatives and a process for the manufacture thereof
GB1461667A (en) Amphetamine derivatives
GB1295040A (en)
GB1397869A (en) 1,8-naphthyridin derivatives
GB1425706A (en) Piperidine derivatives
US3987059A (en) 2-substituted indoles and process for their preparation
GB1127993A (en) Process for the production of piperazine derivatives
GB933504A (en) New piperidine derivatives and methods for preparing the same
GB1383186A (en) Beta-aminoketone derivatives
GB1475114A (en) 4-amino-3-hydrazino-1,2,4-triazole derivatives methods for their preparation and compositions containing them
GB1385811A (en) 1-amino pyrazole derivatives and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee