GB1470861A - Process of controlling foaming in continuous fermentations - Google Patents
Process of controlling foaming in continuous fermentationsInfo
- Publication number
- GB1470861A GB1470861A GB1061674A GB1061674A GB1470861A GB 1470861 A GB1470861 A GB 1470861A GB 1061674 A GB1061674 A GB 1061674A GB 1061674 A GB1061674 A GB 1061674A GB 1470861 A GB1470861 A GB 1470861A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substrate
- foam
- amount
- march
- citric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000855 fermentation Methods 0.000 title abstract 3
- 230000004151 fermentation Effects 0.000 title abstract 3
- 238000005187 foaming Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000000758 substrate Substances 0.000 abstract 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 6
- 239000006260 foam Substances 0.000 abstract 5
- 239000000523 sample Substances 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 241000235015 Yarrowia lipolytica Species 0.000 abstract 1
- 230000003254 anti-foaming effect Effects 0.000 abstract 1
- 239000002518 antifoaming agent Substances 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000012188 paraffin wax Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/02—Means for regulation, monitoring, measurement or control, e.g. flow regulation of foam
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/48—Tricarboxylic acids, e.g. citric acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
1470861 Citric acid PFIZER Ltd 7 March 1975 [8 March 1974] 10616/74 Heading C2C [Also in Division C6] In a continuous fermentation with a microorganism in a nutrient medium in which the main substrate has an antifoaming action, but in which no other antifoaming agent is added, the addition of the substrate to the fermentation broth is controlled by monitoring the amount of the foam and adding a sufficient amount of substrate to reduce the amount of foam when the foam exceeds a predetermined level. An example describes the microbiological production of citric acid by cultivation of Candida lipolytica ATCC 20228 on a C 14 -C 17 n-paraffin substrate. It is stated that the medium first begins to foam when the original hydrocarbon substrate therein has been exhausted. Further foaming occurs as each charge of substrate is used up. The requisite apparatus includes a foam probe 12 electrically connected to a control panel 13 which controls a pump or valve 14 in the substrate supply line 16. The amount of substrate added when the means is actuated may be limited by a timing device (not shown). The apparatus is fitted with an air line 3, and heater 6 and cooler 7 controlled by a temperature probe 8. Specification 1,369,295 is referred to.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1061674A GB1470861A (en) | 1974-03-08 | 1974-03-08 | Process of controlling foaming in continuous fermentations |
| IE501/75A IE40765B1 (en) | 1974-03-08 | 1975-03-07 | Process of controlling foaming in continous fermentations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1061674A GB1470861A (en) | 1974-03-08 | 1974-03-08 | Process of controlling foaming in continuous fermentations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1470861A true GB1470861A (en) | 1977-04-21 |
Family
ID=9971156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1061674A Expired GB1470861A (en) | 1974-03-08 | 1974-03-08 | Process of controlling foaming in continuous fermentations |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB1470861A (en) |
| IE (1) | IE40765B1 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0231145A2 (en) * | 1986-01-17 | 1987-08-05 | Tschudin & Heid AG | Device for the treatment of microorganisms and method for the operation of this device |
| US4752564A (en) * | 1983-07-12 | 1988-06-21 | Phillips Petroleum Company | Fermentation method and apparatus |
| US4987082A (en) * | 1988-08-05 | 1991-01-22 | Shell Internationale Research | Control of foam build up in a fermenter |
| WO1991001788A1 (en) * | 1989-08-11 | 1991-02-21 | Henkel Kommanditgesellschaft Auf Aktien | Dosing installation for treating liquids |
| WO2002079374A2 (en) * | 2001-03-30 | 2002-10-10 | Gadi Steiner | Fermentor volume control using defoamer and defoamer usage information |
| WO2023055747A1 (en) * | 2021-09-29 | 2023-04-06 | Life Technologies Corporation | Adjustable foam sensor systems and related methods |
-
1974
- 1974-03-08 GB GB1061674A patent/GB1470861A/en not_active Expired
-
1975
- 1975-03-07 IE IE501/75A patent/IE40765B1/en unknown
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4752564A (en) * | 1983-07-12 | 1988-06-21 | Phillips Petroleum Company | Fermentation method and apparatus |
| EP0231145A2 (en) * | 1986-01-17 | 1987-08-05 | Tschudin & Heid AG | Device for the treatment of microorganisms and method for the operation of this device |
| EP0231145A3 (en) * | 1986-01-17 | 1988-02-24 | Tschudin & Heid AG | Device for the treatment of microorganisms and method for the operation of this device |
| US4987082A (en) * | 1988-08-05 | 1991-01-22 | Shell Internationale Research | Control of foam build up in a fermenter |
| WO1991001788A1 (en) * | 1989-08-11 | 1991-02-21 | Henkel Kommanditgesellschaft Auf Aktien | Dosing installation for treating liquids |
| EP0415115A2 (en) * | 1989-08-11 | 1991-03-06 | Henkel Kommanditgesellschaft auf Aktien | Dosing installation for the treatment of liquids |
| EP0415115A3 (en) * | 1989-08-11 | 1991-03-27 | Henkel Kommanditgesellschaft Auf Aktien | Dosing installation for the treatment of liquids |
| WO2002079374A2 (en) * | 2001-03-30 | 2002-10-10 | Gadi Steiner | Fermentor volume control using defoamer and defoamer usage information |
| WO2002079374A3 (en) * | 2001-03-30 | 2004-03-18 | Gadi Steiner | Fermentor volume control using defoamer and defoamer usage information |
| WO2023055747A1 (en) * | 2021-09-29 | 2023-04-06 | Life Technologies Corporation | Adjustable foam sensor systems and related methods |
Also Published As
| Publication number | Publication date |
|---|---|
| IE40765B1 (en) | 1979-08-15 |
| IE40765L (en) | 1975-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |