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GB1456618A - Process for the production of solid preparations of sparingly soluble medicinally active compounds in a very finely divided form - Google Patents

Process for the production of solid preparations of sparingly soluble medicinally active compounds in a very finely divided form

Info

Publication number
GB1456618A
GB1456618A GB77475A GB77475A GB1456618A GB 1456618 A GB1456618 A GB 1456618A GB 77475 A GB77475 A GB 77475A GB 77475 A GB77475 A GB 77475A GB 1456618 A GB1456618 A GB 1456618A
Authority
GB
United Kingdom
Prior art keywords
finely divided
sparingly soluble
medicinally active
production
active compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB77475A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB1456618A publication Critical patent/GB1456618A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1456618 Pharmaceutical compositions BAYER AG 8 Jan 1975 [9 Jan 1974] 774/75 Heading A5B Finely divided medicinally active compositions in dry powder form are prepared by forming a solution of a medicinally active substance in polyethylene glycol of M.W. 200 to 1000 in the presence of a surface active agent and adding a solid excipient to the solution to form a dry powder. The compositions are especially suitable for active substances such as Clortrimazol, Mefrusid, Nifedipine, Acetylcarbromal, Sulphathiourea, Sulphamethoxydiazine, Niclofolan, Metronidazol, Sulphadiazine, Sulphadimidine, Phenyltoin, Prothionamide, Sulphathiazole, Benzthiazid, Nifurtimox, Sultiam, Niclosamid, 4-(##-nitrophenyl)-2, 6-dimethyl-1, 4-dihydropyridine-3, 5- dicarboxylic acid bis(2"-propoxyethyl) ester and methylphenobarbital, which are insoluble or sparingly soluble in water and gastric and intestinal juices.
GB77475A 1974-01-09 1975-01-08 Process for the production of solid preparations of sparingly soluble medicinally active compounds in a very finely divided form Expired GB1456618A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19742400819 DE2400819C2 (en) 1974-01-09 1974-01-09 Process for the production of solid preparations of poorly soluble active pharmaceutical ingredients in extremely fine distribution

Publications (1)

Publication Number Publication Date
GB1456618A true GB1456618A (en) 1976-11-24

Family

ID=5904386

Family Applications (1)

Application Number Title Priority Date Filing Date
GB77475A Expired GB1456618A (en) 1974-01-09 1975-01-08 Process for the production of solid preparations of sparingly soluble medicinally active compounds in a very finely divided form

Country Status (6)

Country Link
AT (1) AT338432B (en)
BE (1) BE824186A (en)
DE (1) DE2400819C2 (en)
FR (1) FR2256765B1 (en)
GB (1) GB1456618A (en)
NL (1) NL7500116A (en)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0047899A1 (en) * 1980-09-09 1982-03-24 Bayer Ag Solid pharmaceutical compositions containing nifedipine, and process for their preparation
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
US4411882A (en) 1978-12-21 1983-10-25 Sandoz Ltd. Galenical compositions
US4412986A (en) 1977-06-07 1983-11-01 Yamanouchi Pharmaceutical Co. Ltd. Nifedipine-containing solid preparation composition
US4537898A (en) * 1983-03-03 1985-08-27 Bayer Aktiengesellschaft Liquid formulations of dihydropyridines
EP0163984A2 (en) * 1984-05-23 1985-12-11 Bayer Ag Dihydropyridin combinations and process for their manufacture
EP0164588A2 (en) * 1984-05-23 1985-12-18 Bayer Ag Dihydropyridin compositions and manufacturing process
GB2160100A (en) * 1984-06-14 1985-12-18 Sandoz Ltd Galenical retard formulations
EP0164587A2 (en) * 1984-05-23 1985-12-18 Bayer Ag Nifedipine compositions and process for their preparation
EP0165450A2 (en) * 1984-05-23 1985-12-27 Bayer Ag Nifedipin combinations and manufacturing process
DE3438830A1 (en) * 1984-10-23 1986-04-30 Rentschler Arzneimittel PHARMACEUTICAL FORM CONTAINING NIFEDIPIN AND METHOD FOR THE PRODUCTION THEREOF
US4880623A (en) * 1985-10-15 1989-11-14 Eurand Italia S.P.A. Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained
US5158944A (en) * 1989-03-01 1992-10-27 Teijin Limited Solid pharmaceutical preparations of active form of vitamin d3 of improved stability
US5264446A (en) * 1980-09-09 1993-11-23 Bayer Aktiengesellschaft Solid medicament formulations containing nifedipine, and processes for their preparation
US5594013A (en) * 1992-01-13 1997-01-14 Ethical Pharmaceuticals Limited Pharmaceutical compositions containing nifedipine and process for the preparation thereof
US5837379A (en) * 1997-01-31 1998-11-17 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
US5879714A (en) * 1996-04-24 1999-03-09 Bernard Charles Sherman Controlled-release pharmaceutical compositions
US5922352A (en) * 1997-01-31 1999-07-13 Andrx Pharmaceuticals, Inc. Once daily calcium channel blocker tablet having a delayed release core
US6485748B1 (en) 1997-12-12 2002-11-26 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
WO2009032246A2 (en) * 2007-09-03 2009-03-12 Nanotherapeutics, Inc. Particulate compositions for delivery of poorly soluble drugs

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5332110A (en) * 1976-09-03 1978-03-27 Yamanouchi Pharmaceut Co Ltd Pharmaceutical composition containing gamma-oryzanol
JPS5420127A (en) * 1977-07-14 1979-02-15 Yamanouchi Pharmaceut Co Ltd Solid nifedipine preparaton
JPS542316A (en) * 1977-06-07 1979-01-09 Yamanouchi Pharmaceut Co Ltd Solid pharmaceutical composition containing nifedipene
EP0001247A1 (en) * 1977-09-14 1979-04-04 Kanebo, Ltd. Pharmaceutical preparation containing nifedipine and a method for producing the same.
ATE5852T1 (en) * 1978-11-20 1984-02-15 American Home Products Corporation THERAPEUTIC COMPOSITIONS WITH INCREASED BIOAVAILABILITY AND PROCESS FOR THEIR PREPARATION.
CA1146866A (en) 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
JPS56110612A (en) * 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Readily disintegrable and absorbable compression molded article of slightly soluble drug
CA1173751A (en) * 1980-05-07 1984-09-04 Jack H. Lazarus Methoxsalen dosage forms
JPS57167911A (en) * 1981-04-09 1982-10-16 Kyoto Yakuhin Kogyo Kk Liquid pharmaceutical of nifedipine
JPS58206533A (en) * 1982-05-27 1983-12-01 Teijin Ltd Active type vitamin d3 derivative composition and drug comprising it as active ingredient
JPS58146506A (en) * 1983-01-13 1983-09-01 バイエル・アクチエンゲゼルシヤフト Niphepidine-containing solid medicine
AT385654B (en) * 1984-09-04 1988-05-10 Arcana Chem Pharm Process for the production of oil-containing preparations in granule form for oral administration
WO1987000428A1 (en) * 1985-07-24 1987-01-29 Pyare Seth Oxazepam containing pharmaceutical composition
US5800834A (en) * 1996-06-10 1998-09-01 Spireas; Spiridon Liquisolid systems and methods of preparing same

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4412986A (en) 1977-06-07 1983-11-01 Yamanouchi Pharmaceutical Co. Ltd. Nifedipine-containing solid preparation composition
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
US4411882A (en) 1978-12-21 1983-10-25 Sandoz Ltd. Galenical compositions
EP0047899A1 (en) * 1980-09-09 1982-03-24 Bayer Ag Solid pharmaceutical compositions containing nifedipine, and process for their preparation
JPS5750913A (en) * 1980-09-09 1982-03-25 Bayer Ag Nifedipin-containing solid medicine and manufacture
JPS5914446B2 (en) * 1980-09-09 1984-04-04 バイエル・アクチエンゲゼルシヤフト Solid preparation containing nifedipine and its manufacturing method
US5264446A (en) * 1980-09-09 1993-11-23 Bayer Aktiengesellschaft Solid medicament formulations containing nifedipine, and processes for their preparation
US4537898A (en) * 1983-03-03 1985-08-27 Bayer Aktiengesellschaft Liquid formulations of dihydropyridines
EP0163984A3 (en) * 1984-05-23 1986-03-19 Bayer Ag Dihydropyridin combinations and process for their manufacture
EP0163984A2 (en) * 1984-05-23 1985-12-11 Bayer Ag Dihydropyridin combinations and process for their manufacture
EP0164587A2 (en) * 1984-05-23 1985-12-18 Bayer Ag Nifedipine compositions and process for their preparation
EP0165450A2 (en) * 1984-05-23 1985-12-27 Bayer Ag Nifedipin combinations and manufacturing process
EP0165450A3 (en) * 1984-05-23 1986-03-12 Bayer Ag Nifedipin combinations and manufacturing process
EP0164587A3 (en) * 1984-05-23 1986-03-19 Bayer Ag Nifedipine compositions and process for their preparation
EP0164588A2 (en) * 1984-05-23 1985-12-18 Bayer Ag Dihydropyridin compositions and manufacturing process
EP0164588A3 (en) * 1984-05-23 1986-03-19 Bayer Ag Dihydropyridin compositions and manufacturing process
GB2160100A (en) * 1984-06-14 1985-12-18 Sandoz Ltd Galenical retard formulations
DE3438830A1 (en) * 1984-10-23 1986-04-30 Rentschler Arzneimittel PHARMACEUTICAL FORM CONTAINING NIFEDIPIN AND METHOD FOR THE PRODUCTION THEREOF
US4880623A (en) * 1985-10-15 1989-11-14 Eurand Italia S.P.A. Process for the preparation of solid nifedipine formulations of high bioavailability and with sustained effect, and formulations thus obtained
US5158944A (en) * 1989-03-01 1992-10-27 Teijin Limited Solid pharmaceutical preparations of active form of vitamin d3 of improved stability
US5594013A (en) * 1992-01-13 1997-01-14 Ethical Pharmaceuticals Limited Pharmaceutical compositions containing nifedipine and process for the preparation thereof
US5879714A (en) * 1996-04-24 1999-03-09 Bernard Charles Sherman Controlled-release pharmaceutical compositions
US5837379A (en) * 1997-01-31 1998-11-17 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
US5922352A (en) * 1997-01-31 1999-07-13 Andrx Pharmaceuticals, Inc. Once daily calcium channel blocker tablet having a delayed release core
US6485748B1 (en) 1997-12-12 2002-11-26 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
WO2009032246A2 (en) * 2007-09-03 2009-03-12 Nanotherapeutics, Inc. Particulate compositions for delivery of poorly soluble drugs
WO2009032246A3 (en) * 2007-09-03 2009-04-23 Nanotherapeutics Inc Particulate compositions for delivery of poorly soluble drugs
US8377479B2 (en) 2007-09-03 2013-02-19 Nanotherapeutics, Inc. Compositions and methods for delivery of poorly soluble drugs
AU2008296971B2 (en) * 2007-09-03 2014-10-02 Nanoshift, Llc Particulate compositions for delivery of poorly soluble drugs
US9554996B2 (en) 2007-09-03 2017-01-31 Nanotherapeutics, Inc. Compositions and methods for delivery of poorly soluble drugs

Also Published As

Publication number Publication date
BE824186A (en) 1975-07-08
DE2400819A1 (en) 1975-07-17
AT338432B (en) 1977-08-25
FR2256765A1 (en) 1975-08-01
FR2256765B1 (en) 1978-09-22
NL7500116A (en) 1975-07-11
DE2400819C2 (en) 1982-04-22
ATA6375A (en) 1976-12-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee