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GB1424432A - Pharmaceutical compositions - Google Patents

Pharmaceutical compositions

Info

Publication number
GB1424432A
GB1424432A GB1415873A GB1415873A GB1424432A GB 1424432 A GB1424432 A GB 1424432A GB 1415873 A GB1415873 A GB 1415873A GB 1415873 A GB1415873 A GB 1415873A GB 1424432 A GB1424432 A GB 1424432A
Authority
GB
United Kingdom
Prior art keywords
penicillamine
compositions
march
radical
acyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1415873A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DEUTSCHE GOLD- und SIBLERSCHEIDEANSTALT
Evonik Operations GmbH
Original Assignee
DEUTSCHE GOLD- und SIBLERSCHEIDEANSTALT
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2214814A external-priority patent/DE2214814A1/en
Priority claimed from DE19722233993 external-priority patent/DE2233993A1/en
Application filed by DEUTSCHE GOLD- und SIBLERSCHEIDEANSTALT, Degussa GmbH filed Critical DEUTSCHE GOLD- und SIBLERSCHEIDEANSTALT
Publication of GB1424432A publication Critical patent/GB1424432A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

1424432 Compositions containing synthetic D-penicillamine DEUTSCHE GOLD-UND SILBER - SOHEIDEANSTALT 23 March 1973 [25 March 1972 11 July 1972] 14158/73 Heading A5B [Also in Division C2] A pharmaceutical composition comprises fully synthetic D-penicillamine obtained by resolution of a D, L-penicillamine derivative of general formula: in which Ac represents an acyl group, Z represents H or together with Ac represents a diacyl radical, R represents H, a benzyl radical or an acyl group and R<SP>1</SP> and R<SP>2</SP> which may be the same or different, each represent H, C 1 -C<SP>8</SP> alkyl or a cycloalkyl or aryl radical, with an optically active base and converting the D-isomer obtained to D-penicillamine, together with at least one pharmaceutically acceptable additive or excipient. The compositions may be made up in forms suitable for oral, parenteral, rectal, vaginal or local administration or may be in the form of an inhalation. The compositions may contain other active ingredients such as analgesics, antihistamines, antiphlogistics, spasmolytics, geriatics, liver therapeutics, vitamins, trace elements and steroids. In examples salicylamide, α-tocopherol and ascorbic acid may be present.
GB1415873A 1972-03-25 1973-03-23 Pharmaceutical compositions Expired GB1424432A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2214814A DE2214814A1 (en) 1972-03-25 1972-03-25 Synthetic d-penicillamine prepns - useful against fibrosis polyarthritis aggressive hepatitis etc
DE19722233993 DE2233993A1 (en) 1972-07-11 1972-07-11 Synthetic D-penicillamine prepns - obtd by optical resolution

Publications (1)

Publication Number Publication Date
GB1424432A true GB1424432A (en) 1976-02-11

Family

ID=25762971

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1415873A Expired GB1424432A (en) 1972-03-25 1973-03-23 Pharmaceutical compositions

Country Status (5)

Country Link
FR (1) FR2182892B1 (en)
GB (1) GB1424432A (en)
IL (1) IL41868A (en)
NL (1) NL7304113A (en)
OA (1) OA04527A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847297A (en) * 1985-06-08 1989-07-11 Degussa Aktiengesellschaft Use of penicillamine for treating immune damaging illnesses
WO2019111193A1 (en) * 2017-12-09 2019-06-13 Kashiv Pharma Llc A stable pharmaceutical composition comprising penicillamine
US11090294B2 (en) 2009-12-01 2021-08-17 Glaxo Group Limited Combinations of a muscarinic receptor antagonist and a beta-2 adrenoreceptor agonist
US11116721B2 (en) 2009-02-26 2021-09-14 Glaxo Group Limited Pharmaceutical formulations comprising 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl) phenol

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2304054C3 (en) * 1973-01-27 1982-04-08 Degussa Ag, 6000 Frankfurt Process for obtaining D-penicillamine
DE2304055C3 (en) * 1973-01-27 1982-04-29 Degussa Ag, 6000 Frankfurt Process for the production of D-penicillamine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1015108A (en) * 1946-03-22 1952-08-27 Merck & Co Inc Process for the preparation of penicillin derivatives and products resulting therefrom
BE786964A (en) * 1971-07-30 1973-01-29 Degussa PROCEDURE FOR OBTAINING D-PENICILLAMINE

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847297A (en) * 1985-06-08 1989-07-11 Degussa Aktiengesellschaft Use of penicillamine for treating immune damaging illnesses
US11116721B2 (en) 2009-02-26 2021-09-14 Glaxo Group Limited Pharmaceutical formulations comprising 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl) phenol
US11090294B2 (en) 2009-12-01 2021-08-17 Glaxo Group Limited Combinations of a muscarinic receptor antagonist and a beta-2 adrenoreceptor agonist
WO2019111193A1 (en) * 2017-12-09 2019-06-13 Kashiv Pharma Llc A stable pharmaceutical composition comprising penicillamine

Also Published As

Publication number Publication date
IL41868A0 (en) 1973-05-31
IL41868A (en) 1976-02-29
OA04527A (en) 1980-03-30
FR2182892A1 (en) 1973-12-14
FR2182892B1 (en) 1976-11-05
AU5367973A (en) 1974-09-26
NL7304113A (en) 1973-09-27

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee